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Artificial intelligence (AI) classification holds promise as a novel and affordable screening tool for clinical management of ocular diseases. Rural and underserved areas, which suffer from lack of access to experienced ophthalmologists may…

Quantitative Methods · Quantitative Biology 2019-06-19 Minhaj Alam , David Le , Jennifer I. Lim , R. V. P. Chan , Xincheng Yao

Diabetic Retinopathy (DR), an ocular complication of diabetes, is a leading cause of blindness worldwide. Traditionally, DR is monitored using Color Fundus Photography (CFP), a widespread 2-D imaging modality. However, DR classifications…

Optical Coherence Tomography Angiography (OCTA) is a crucial imaging technique for visualizing retinal vasculature and diagnosing eye diseases such as diabetic retinopathy and glaucoma. However, precise segmentation of OCTA vasculature…

Image and Video Processing · Electrical Eng. & Systems 2025-01-03 Shun Zou , Zhuo Zhang , Guangwei Gao

Optical coherence tomography (OCT) angiography is a well-established in vivo imaging technique to assess the overall vascular morphology of tissues and is an emerging field of research for the assessment of blood flow dynamics and…

Medical Physics · Physics 2019-07-02 Cerine Lal , Hrebesh M Subhash , Sergey Alexandrov , Martin J Leahy

The area of the foveal avascular zone (FAZ) from en face images of optical coherence tomography angiography (OCTA) is one of the most common measurement based on this technology. However, its use in clinic is limited by the high variation…

Image and Video Processing · Electrical Eng. & Systems 2021-12-07 Giovanni Ometto , Giovanni Montesano , Usha Chakravarthy , Frank Kee , Ruth E. Hogg , David P. Crabb

Eye diseases are common in older Americans and can lead to decreased vision and blindness. Recent advancements in imaging technologies allow clinicians to capture high-quality images of the retinal blood vessels via Optical Coherence…

Computer Vision and Pattern Recognition · Computer Science 2024-07-23 Jacob Thrasher , Annahita Amireskandari , Prashnna Gyawali

Optical Coherence Tomography Angiography (OCTA) and its derived en-face projections provide high-resolution visualization of the retinal and choroidal vasculature, which is critical for the rapid and accurate diagnosis of retinal diseases.…

Computer Vision and Pattern Recognition · Computer Science 2025-09-10 Pooya Khosravi , Kun Han , Anthony T. Wu , Arghavan Rezvani , Zexin Feng , Xiaohui Xie

Age-related macular degeneration (AMD) is characterized by early micro-vascular alterations that can be captured non-invasively using optical coherence tomography angiography (OCTA), yet most deep learning (DL) models rely on global…

Computer Vision and Pattern Recognition · Computer Science 2026-03-10 Margalit G. Mitzner , Moinak Bhattacharya , Zhilin Zou , Chao Chen , Prateek Prasanna

We report on the simultaneous and localized measurements of the diffusion coefficient and flow velocity based on the normalized autocorrelation function using optical coherence tomography (OCT). Our results on a flowing solution of…

Optics · Physics 2015-02-05 Nicolás Weiss , Ton G. van Leeuwen , Jeroen Kalkman

Optical Coherence Tomography Angiography (OCTA) is a non-invasive imaging technique that provides high-resolution cross-sectional images of the retina, which are useful for diagnosing and monitoring various retinal diseases. However, manual…

Image and Video Processing · Electrical Eng. & Systems 2023-11-07 Can Koz , Onat Dalmaz , Mertay Dayanc

Retinal neovascularization (RNV) is a vision threatening development in diabetic retinopathy (DR). Vision loss associated with RNV is preventable with timely intervention, making RNV clinical screening and monitoring a priority. Optical…

Image and Video Processing · Electrical Eng. & Systems 2026-04-01 Jinyi Hao , Jie Wang , Liqin Gao , Tristan T. Hormel , Yukun Guo , An-Lun Wu , Christina J. Flaxel , Steven T. Bailey , Kotaro Tsuboi , Thomas S. Hwang , Yali Jia

Automated detection of retinal structures, such as retinal vessels (RV), the foveal avascular zone (FAZ), and retinal vascular junctions (RVJ), are of great importance for understanding diseases of the eye and clinical decision-making. In…

Image and Video Processing · Electrical Eng. & Systems 2022-08-24 Jinkui Hao , Ting Shen , Xueli Zhu , Yonghuai Liu , Ardhendu Behera , Dan Zhang , Bang Chen , Jiang Liu , Jiong Zhang , Yitian Zhao

Optical Coherence Tomography Angiography (OCTA) has been increasingly used in the management of eye and systemic diseases in recent years. Manual or automatic analysis of blood vessel in 2D OCTA images (en face angiograms) is commonly used…

Image and Video Processing · Electrical Eng. & Systems 2021-03-01 Shuai Yu , Jianyang Xie , Jinkui Hao , Yalin Zheng , Jiong Zhang , Yan Hu , Jiang Liu , Yitian Zhao

Optical coherence tomography angiography (OCTA) is a non-invasive imaging technique widely used to study vascular structures and micro-circulation dynamics in the retina and choroid. OCTA has been widely used in clinics for diagnosing…

Image and Video Processing · Electrical Eng. & Systems 2025-08-26 Kejie Chen , Guanbing Gao , Xiaochun Yang , Wenbo Wang , Jing Na

We performed non-invasive video imaging of retinal blood flow in a pigmented rat by holographic interferometry of near-infrared laser light backscattered by retinal tissue, beating against an off-axis reference beam sampled at a frame rate…

Instrumentation and Detectors · Physics 2016-07-27 Mathilde Pellizzari , Manuel Simonutti , Julie Degardin , Jose-Alain Sahel , Mathias Fink , Michel Paques , Michael Atlan

Handheld Optical Coherence Tomography Angiography (OCTA) enables noninvasive retinal imaging in uncooperative or pediatric subjects, but is highly susceptible to motion artifacts that severely degrade volumetric image quality. Sudden motion…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Nick DiSanto , Ehsan Khodapanah Aghdam , Han Liu , Jacob Watson , Yuankai K. Tao , Hao Li , Ipek Oguz

Targeted diagnosis and treatment plans for patients with coronary artery disease vary according to atherosclerotic plaque component. Coronary CT angiography (CCTA) is widely used for artery imaging and determining the stenosis degree.…

Image and Video Processing · Electrical Eng. & Systems 2023-08-14 Jun Li , Kexin Li , Yafeng Zhou , S. Kevin Zhou

Angiography by Optical Coherence Tomography is a non-invasive retinal imaging modality of recent appearance that allows the visualization of the vascular structure at predefined depths based on the detection of the blood movement. OCT-A…

Computer Vision and Pattern Recognition · Computer Science 2019-03-06 Macarena Díaz , Jorge Novo , Paula Cutrín , Francisco Gómez-Ulla , Manuel G. Penedo , Marcos Ortega

A polarization-multiplexed, dual-beam setup is proposed to expand the field of view for a swept source optical coherence tomography angiography (OCTA) system. This method used a Wollaston prism to split sample path light into two…

Medical Physics · Physics 2017-10-30 Jianlong Yang , Rahul Chandwani , Rui Zhao , Zhuo Wang , Yali Jia , David Huang , Gangjun Liu

Retinal optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) are promising tools for the (early) diagnosis of Alzheimer's disease (AD). These non-invasive imaging techniques are cost-effective and more…

Image and Video Processing · Electrical Eng. & Systems 2022-09-09 Yasemin Turkan , F. Boray Tek