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With the advancement of internet communication and telemedicine, people are increasingly turning to the web for various healthcare activities. With an ever-increasing number of diseases and symptoms, diagnosing patients becomes challenging.…

Artificial Intelligence · Computer Science 2024-05-21 Mohit Tomar , Abhisek Tiwari , Sriparna Saha

Interference between pharmacological substances can cause serious medical injuries. Correctly predicting so-called drug-drug interactions (DDI) does not only reduce these cases but can also result in a reduction of drug development cost.…

Machine Learning · Computer Science 2019-08-06 Md. Rezaul Karim , Michael Cochez , Joao Bosco Jares , Mamtaz Uddin , Oya Beyan , Stefan Decker

Many mathematical models have been leveraged to design embeddings for representing Knowledge Graph (KG) entities and relations for link prediction and many downstream tasks. These mathematically-inspired models are not only highly scalable…

Artificial Intelligence · Computer Science 2023-09-25 Xiou Ge , Yun-Cheng Wang , Bin Wang , C. -C. Jay Kuo

Since large knowledge bases are typically incomplete, missing facts need to be inferred from observed facts in a task called knowledge base completion. The most successful approaches to this task have typically explored explicit paths…

Artificial Intelligence · Computer Science 2018-04-24 Yelong Shen , Po-Sen Huang , Ming-Wei Chang , Jianfeng Gao

Identifying disease genes from human genome is an important and fundamental problem in biomedical research. Despite many publications of machine learning methods applied to discover new disease genes, it still remains a challenge because of…

Quantitative Methods · Quantitative Biology 2017-05-23 Peng Yang

Multi-modal neuroimaging technology has greatlly facilitated the efficiency and diagnosis accuracy, which provides complementary information in discovering objective disease biomarkers. Conventional deep learning methods, e.g. convolutional…

Image and Video Processing · Electrical Eng. & Systems 2022-10-26 Yanwu Yang , Xutao Guo , Zhikai Chang , Chenfei Ye , Yang Xiang , Ting Ma

Identifying relationships between concepts is a key aspect of scientific knowledge synthesis. Finding these links often requires a researcher to laboriously search through scien- tific papers and databases, as the size of these resources…

Computation and Language · Computer Science 2016-02-12 Stephanie L. Hyland , Theofanis Karaletsos , Gunnar Rätsch

It is a common practice in modern medicine to prescribe multiple medications simultaneously to treat diseases. However, these medications could have adverse reactions between them, known as Drug-Drug Interactions (DDI), which have the…

Machine Learning · Computer Science 2024-12-10 Azwad Tamir , Jiann-Shiun Yuan

We have created a knowledge graph based on major data sources used in ecotoxicological risk assessment. We have applied this knowledge graph to an important task in risk assessment, namely chemical effect prediction. We have evaluated nine…

Artificial Intelligence · Computer Science 2022-03-31 Erik B. Myklebust , Ernesto Jiménez-Ruiz , Jiaoyan Chen , Raoul Wolf , Knut Erik Tollefsen

Knowledge Graphs (KG) and associated Knowledge Graph Embedding (KGE) models have recently begun to be explored in the context of drug discovery and have the potential to assist in key challenges such as target identification. In the drug…

Biomolecules · Quantitative Biology 2022-06-01 Stephen Bonner , Ian P Barrett , Cheng Ye , Rowan Swiers , Ola Engkvist , Charles Tapley Hoyt , William L Hamilton

Knowledge graphs (KGs) have become valuable knowledge resources in various applications, and knowledge graph embedding (KGE) methods have garnered increasing attention in recent years. However, conventional KGE methods still face challenges…

Computation and Language · Computer Science 2023-12-19 Mingyang Chen , Wen Zhang , Yuxia Geng , Zezhong Xu , Jeff Z. Pan , Huajun Chen

Real-world knowledge graphs (KG) are mostly incomplete. The problem of recovering missing relations, called KG completion, has recently become an active research area. Knowledge graph (KG) embedding, a low-dimensional representation of…

Artificial Intelligence · Computer Science 2022-07-01 Minsang Kim , Seungjun Baek

Learning low-dimensional embeddings of knowledge graphs is a powerful approach used to predict unobserved or missing edges between entities. However, an open challenge in this area is developing techniques that can go beyond simple edge…

Social and Information Networks · Computer Science 2019-10-30 William L. Hamilton , Payal Bajaj , Marinka Zitnik , Dan Jurafsky , Jure Leskovec

Drug recommendation (DR) systems aim to support healthcare professionals in selecting appropriate medications based on patients' medical conditions. State-of-the-art approaches utilize deep learning techniques for improving DR, but fall…

Information Retrieval · Computer Science 2025-11-03 Yu Lin , Zhen Jia , Philipp Christmann , Xu Zhang , Shengdong Du , Tianrui Li

Knowledge graph completion aims to address the problem of extending a KG with missing triples. In this paper, we provide an approach GenKGC, which converts knowledge graph completion to sequence-to-sequence generation task with the…

Computation and Language · Computer Science 2023-03-15 Xin Xie , Ningyu Zhang , Zhoubo Li , Shumin Deng , Hui Chen , Feiyu Xiong , Mosha Chen , Huajun Chen

Commonsense knowledge graph reasoning(CKGR) is the task of predicting a missing entity given one existing and the relation in a commonsense knowledge graph (CKG). Existing methods can be classified into two categories generation method and…

Computation and Language · Computer Science 2020-08-14 Cunxiang Wang , Jinhang Wu , Luxin Liu , Yue Zhang

In the rapidly evolving field of metabolic engineering, the quest for efficient and precise gene target identification for metabolite production enhancement presents significant challenges. Traditional approaches, whether knowledge-based or…

Artificial Intelligence · Computer Science 2024-11-01 Kexuan Xin , Qingyun Wang , Junyu Chen , Pengfei Yu , Huimin Zhao , Heng Ji

Knowledge graph embedding (KGE), aiming to embed entities and relations into low-dimensional vectors, has attracted wide attention recently. However, the existing research is mainly based on the black-box neural models, which makes it…

Computation and Language · Computer Science 2020-11-13 Xiaoyu Kou , Yankai Lin , Yuntao Li , Jiahao Xu , Peng Li , Jie Zhou , Yan Zhang

Recent advances in research have demonstrated the effectiveness of knowledge graphs (KG) in providing valuable external knowledge to improve recommendation systems (RS). A knowledge graph is capable of encoding high-order relations that…

Information Retrieval · Computer Science 2020-04-02 Yang Gao , Yi-Fan Li , Yu Lin , Hang Gao , Latifur Khan

The goal of representation learning of knowledge graph is to encode both entities and relations into a low-dimensional embedding spaces. Many recent works have demonstrated the benefits of knowledge graph embedding on knowledge graph…

Artificial Intelligence · Computer Science 2019-10-11 Wenqiang Liu , Hongyun Cai , Xu Cheng , Sifa Xie , Yipeng Yu , Hanyu Zhang
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