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The identification of disease-gene associations is instrumental in understanding the mechanisms of diseases and developing novel treatments. Besides identifying genes from RNA-Seq datasets, it is often necessary to identify gene clusters…

Genomics · Quantitative Biology 2025-11-14 Jake R. Patock , Rinki Ratnapriya , Arko Barman

Knowledge graph embedding aims to predict the missing relations between entities in knowledge graphs. Tensor-decomposition-based models, such as ComplEx, provide a good trade-off between efficiency and expressiveness, that is crucial…

Artificial Intelligence · Computer Science 2022-10-05 Hung Nghiep Tran , Atsuhiro Takasu

Knowledge graph embedding (KGE) aims at learning powerful representations to benefit various artificial intelligence applications. Meanwhile, contrastive learning has been widely leveraged in graph learning as an effective mechanism to…

Artificial Intelligence · Computer Science 2023-06-14 Ke Liang , Yue Liu , Sihang Zhou , Wenxuan Tu , Yi Wen , Xihong Yang , Xiangjun Dong , Xinwang Liu

Addressing the incompleteness problem in knowledge graph remains a significant challenge. Current knowledge graph completion methods have their limitations. For example, ComDensE is prone to overfitting and suffers from the degradation with…

Information Retrieval · Computer Science 2024-10-10 Chuhong Yang , Bin Li , Nan Wu

Knowledge graph completion (KGC) has become a focus of attention across deep learning community owing to its excellent contribution to numerous downstream tasks. Although recently have witnessed a surge of work on KGC, they are still…

Artificial Intelligence · Computer Science 2021-10-12 Junkang Wu , Wentao Shi , Xuezhi Cao , Jiawei Chen , Wenqiang Lei , Fuzheng Zhang , Wei Wu , Xiangnan He

Graph convolutional neural networks have recently shown great potential for the task of zero-shot learning. These models are highly sample efficient as related concepts in the graph structure share statistical strength allowing…

Computer Vision and Pattern Recognition · Computer Science 2019-03-28 Michael Kampffmeyer , Yinbo Chen , Xiaodan Liang , Hao Wang , Yujia Zhang , Eric P. Xing

Knowledge graph completion (KGC) can predict missing links and is crucial for real-world knowledge graphs, which widely suffer from incompleteness. KGC methods assume a knowledge graph is static, but that may lead to inaccurate prediction…

Artificial Intelligence · Computer Science 2023-11-14 Borui Cai , Yong Xiang , Longxiang Gao , He Zhang , Yunfeng Li , Jianxin Li

Knowledge Graph Completion is a task of expanding the knowledge graph/base through estimating possible entities, or proper nouns, that can be connected using a set of predefined relations, or verb/predicates describing interconnections of…

Computation and Language · Computer Science 2021-01-25 Tong Chen , Sirou Zhu , Yiming Wen , Zhaomin Zheng

This paper presents a novel approach to network management by integrating intent-based networking (IBN) with knowledge graphs (KGs), creating a more intuitive and efficient pipeline for service orchestration. By mapping high-level business…

Networking and Internet Architecture · Computer Science 2024-05-14 Kashif Mehmood , Katina Kralevska , David Palma

Graphs are widely used as a natural framework that captures interactions between individual elements represented as nodes in a graph. In medical applications, specifically, nodes can represent individuals within a potentially large…

Medical diagnosis is the process of making a prediction of the disease a patient is likely to have, given a set of symptoms and observations. This requires extensive expert knowledge, in particular when covering a large variety of diseases.…

Artificial Intelligence · Computer Science 2022-04-29 Niclas Heilig , Jan Kirchhoff , Florian Stumpe , Joan Plepi , Lucie Flek , Heiko Paulheim

Trisomy 21 results in Down syndrome, a multifaceted genetic disorder with diverse clinical phenotypes, including heart defects, immune dysfunction, neurodevelopmental differences, and early-onset dementia risk. Heterogeneity and fragmented…

Gene-gene interactions play a crucial role in the manifestation of complex human diseases. Uncovering significant gene-gene interactions is a challenging task. Here, we present an innovative approach utilizing data-driven computational…

Artificial Intelligence · Computer Science 2024-10-22 Yifan Wu , Yuntao Yang , Zirui Liu , Zhao Li , Khushbu Pahwa , Rongbin Li , Wenjin Zheng , Xia Hu , Zhaozhuo Xu

This paper tackles the problem of endogenous link prediction for Knowledge Base completion. Knowledge Bases can be represented as directed graphs whose nodes correspond to entities and edges to relationships. Previous attempts either…

Artificial Intelligence · Computer Science 2015-06-03 Alberto Garcia-Duran , Antoine Bordes , Nicolas Usunier , Yves Grandvalet

Knowledge graphs are structured representations of real world facts. However, they typically contain only a small subset of all possible facts. Link prediction is a task of inferring missing facts based on existing ones. We propose TuckER,…

Machine Learning · Computer Science 2019-11-07 Ivana Balažević , Carl Allen , Timothy M. Hospedales

Recent progress in deep learning is revolutionizing the healthcare domain including providing solutions to medication recommendations, especially recommending medication combination for patients with complex health conditions. Existing…

Artificial Intelligence · Computer Science 2019-03-08 Junyuan Shang , Cao Xiao , Tengfei Ma , Hongyan Li , Jimeng Sun

Social determinants of health (SDoH) play a crucial role in patient health outcomes, yet their integration into biomedical knowledge graphs remains underexplored. This study addresses this gap by constructing an SDoH-enriched knowledge…

Artificial Intelligence · Computer Science 2024-12-03 Tianqi Shang , Weiqing He , Tianlong Chen , Ying Ding , Huanmei Wu , Kaixiong Zhou , Li Shen

Knowledge Graph Completion (KGC) predicts missing facts in an incomplete Knowledge Graph. Almost all of existing KGC research is applicable to only one KG at a time, and in one language only. However, different language speakers may…

Artificial Intelligence · Computer Science 2021-04-20 Harkanwar Singh , Prachi Jain , Mausam , Soumen Chakrabarti

Much of the natural variation for a complex trait can be explained by variation in DNA sequence levels. As part of sequence variation, gene-gene interaction has been ubiquitously observed in nature, where its role in shaping the development…

Applications · Statistics 2012-10-01 Shaoyu Li , Yuehua Cui

One component of precision medicine is to construct prediction models with their predictive ability as high as possible, e.g. to enable individual risk prediction. In genetic epidemiology, complex diseases have a polygenic basis and a…

Machine Learning · Statistics 2019-01-28 Damian Gola , Inke R. König
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