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Genome sequence analysis is a powerful tool in medical and scientific research. Considering the inevitable sequencing errors and genetic variations, approximate string matching (ASM) has been adopted in practice for genome sequencing.…

Memristive in-memory sorting has been proposed recently to improve hardware sorting efficiency. Using iterative in-memory min computations, data movements between memory and external processing units can be eliminated for improved latency…

Hardware Architecture · Computer Science 2022-02-22 Lianfeng Yu , Zhaokun Jing , Yuchao Yang , Yaoyu Tao

We introduce PRISM (Predictive Reasoning in Sequential Medicine), a transformer-based architecture designed to model the sequential progression of clinical decision-making processes. Unlike traditional approaches that rely on isolated…

Computation and Language · Computer Science 2025-06-16 Lionel Levine , John Santerre , Alex S. Young , T. Barry Levine , Francis Campion , Majid Sarrafzadeh

Large Language Model (LLM) inference requires substantial computational resources, yet CPU-based inference remains essential for democratizing AI due to the widespread availability of CPUs compared to specialized accelerators. However,…

Hardware Architecture · Computer Science 2025-10-01 Jingyao Zhang , Jaewoo Park , Jongeun Lee , Elaheh Sadredini

This paper discusses recent research that aims to enable computation close to data, an approach we broadly call processing-in-memory (PIM). PIM places computation mechanisms in or near where the data is stored (i.e., inside memory chips or…

Hardware Architecture · Computer Science 2025-02-07 Onur Mutlu , Saugata Ghose , Juan Gómez-Luna , Rachata Ausavarungnirun , Mohammad Sadrosadati , Geraldo F. Oliveira

Traditional Von Neumann computing is falling apart in the era of exploding data volumes as the overhead of data transfer becomes forbidding. Instead, it is more energy-efficient to fuse compute capability with memory where the data reside.…

The vast majority of biological sequences encode unknown functions and bear little resemblance to experimentally characterized proteins, limiting both our understanding of biology and our ability to harness functional potential for the…

Quantitative Methods · Quantitative Biology 2026-02-19 Ashley Babjac , Adrienne Hoarfrost

Data movement between memory and processors is a major bottleneck in modern computing systems. The processing-in-memory (PIM) paradigm aims to alleviate this bottleneck by performing computation inside memory chips. Real PIM hardware (e.g.,…

Hardware Architecture · Computer Science 2023-10-04 Jinfan Chen , Juan Gómez-Luna , Izzat El Hajj , Yuxin Guo , Onur Mutlu

Processing-in-memory (PIM) architecture is an inherent match for data analytics application, but we observe major challenges to address when accelerating it using PIM. In this paper, we propose Darwin, a practical LRDIMM-based multi-level…

Systems and Control · Electrical Eng. & Systems 2025-09-23 Donghyuk Kim , Jae-Young Kim , Wontak Han , Jongsoon Won , Haerang Choi , Yongkee Kwon , Joo-Young Kim

Convolutional neural networks (CNN) have become a ubiquitous algorithm with growing applications in mobile and edge settings. We describe a compute-in-memory (CIM) technique called FPIRM using Racetrack Memory (RM) to accelerate CNNs for…

Emerging Technologies · Computer Science 2022-08-02 Sébastien Ollivier , Xinyi Zhang , Yue Tang , Chayanika Choudhuri , Jingtong Hu , Alex K. Jones

Motivation: Deep learning architectures have recently demonstrated their power in predicting DNA- and RNA-binding specificities. Existing methods fall into three classes: Some are based on Convolutional Neural Networks (CNNs), others use…

Machine Learning · Computer Science 2019-01-31 Ameni Trabelsi , Mohamed Chaabane , Asa Ben Hur

Processing-in-cache (PiC) and Processing-in-memory (PiM) architectures, especially those utilizing bit-line computing, offer promising solutions to mitigate data movement bottlenecks within the memory hierarchy. While previous studies have…

Computers and Society · Computer Science 2024-07-30 Dhruv Gajaria , Tosiron Adegbija , Kevin Gomez

Dedicated hardware implementations of spiking neural networks that combine the advantages of mixed-signal neuromorphic circuits with those of emerging memory technologies have the potential of enabling ultra-low power pervasive sensory…

Digital Computing-in-Memory (DCIM) is an innovative technology that integrates multiply-accumulation (MAC) logic directly into memory arrays to enhance the performance of modern AI computing. However, the need for customized memory cells…

Compute-in-memory (CiM) is a promising approach to improving the computing speed and energy efficiency in dataintensive applications. Beyond existing CiM techniques of bitwise logic-in-memory operations and dot product operations, this…

Hardware Architecture · Computer Science 2023-01-03 Yiming Chen , Yushen Fu , Mingyen Lee , Sumitha George , Yongpan Liu , Vijaykrishnan Narayanan , Huazhong Yang , Xueqing Li

Recent research has sought to accelerate cryptographic hash functions as they are at the core of modern cryptography. Traditional designs, however, suffer from the von Neumann bottleneck that originates from the separation of processing and…

Hardware Architecture · Computer Science 2022-06-03 Batel Oved , Orian Leitersdorf , Ronny Ronen , Shahar Kvatinsky

DL inference queries play an important role in diverse internet services and a large fraction of datacenter cycles are spent on processing DL inference queries. Specifically, the matrix-matrix multiplication (GEMM) operations of…

Hardware Architecture · Computer Science 2020-12-02 Benjamin Y. Cho , Jeageun Jung , Mattan Erez

Nanopore sequencing is a widely-used high-throughput genome sequencing technology that can sequence long fragments of a genome into raw electrical signals at low cost. Nanopore sequencing requires two computationally-costly processing steps…

Clustering is a widely used unsupervised learning technique involving an intensive discrete optimization problem. Associative Memory models or AMs are differentiable neural networks defining a recursive dynamical system, which have been…

Machine Learning · Computer Science 2023-06-07 Bishwajit Saha , Dmitry Krotov , Mohammed J. Zaki , Parikshit Ram

Processing-in-memory (PIM), as a novel computing paradigm, provides significant performance benefits from the aspect of effective data movement reduction. SRAM-based PIM has been demonstrated as one of the most promising candidates due to…

Hardware Architecture · Computer Science 2023-11-01 Cenlin Duan , Jianlei Yang , Xiaolin He , Yingjie Qi , Yikun Wang , Yiou Wang , Ziyan He , Bonan Yan , Xueyan Wang , Xiaotao Jia , Weitao Pan , Weisheng Zhao