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Gene annotation has traditionally required direct comparison of DNA sequences between an unknown gene and a database of known ones using string comparison methods. However, these methods do not provide useful information when a gene does…

Machine Learning · Computer Science 2019-09-17 James K. Senter , Taylor M. Royalty , Andrew D. Steen , Amir Sadovnik

Modern Artificial Intelligence (AI) applications are increasingly utilizing multi-tenant deep neural networks (DNNs), which lead to a significant rise in computing complexity and the need for computing parallelism. ReRAM-based…

Emerging Technologies · Computer Science 2024-08-12 Bojing Li , Duo Zhong , Xiang Chen , Chenchen Liu

DNA sequencing is the physical/biochemical process of identifying the location of the four bases (Adenine, Guanine, Cytosine, Thymine) in a DNA strand. As semiconductor technology revolutionized computing, modern DNA sequencing technology…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-05-06 S. Karen Khatamifard , Zamshed Chowdhury , Nakul Pande , Meisam Razaviyayn , Chris Kim , Ulya R. Karpuzcu

Indexing is a well-known database technique used to facilitate data access and speed up query processing. Nevertheless, the construction and modification of indexes are very expensive. In traditional approaches, all records in the database…

Databases · Computer Science 2023-06-22 Wojciech Macyna , Michal Kukowski

As the dimensionality of modern learned representations increases to thousands of dimensions, the state-of-the-art Approximate Nearest Neighbor (ANN) indices exhibit severe limitations. Graph-based methods (e.g., HNSW) suffer from…

Graph Neural Networks (GNNs) are emerging ML models to analyze graph-structure data. Graph Neural Network (GNN) execution involves both compute-intensive and memory-intensive kernels, the latter dominates the total time, being significantly…

Accurate intraoperative assessment of glioma infiltration is essential for maximizing tumor resection while preserving functional brain tissue. Fluorescence lifetime imaging (FLIm) offers real-time, label-free biochemical contrast, but its…

Computer Vision and Pattern Recognition · Computer Science 2026-04-30 Silvia Noble Anbunesan , Mohamed Abul Hassan , Jinyi Qi , Lisanne Kraft , Han Sung Lee , Orin Bloch , Laura Marcu

Structured sparsity enables deploying large language models (LLMs) on resource-constrained systems. Approaches like dense-to-sparse fine-tuning are particularly compelling, achieving remarkable structured sparsity by reducing the model size…

Hardware Architecture · Computer Science 2025-10-14 João Paulo Cardoso de Lima , Marc Dietrich , Jeronimo Castrillon , Asif Ali Khan

In recent years, various computing-in-memory (CIM) processors have been presented, showing superior performance over traditional architectures. To unleash the potential of various CIM architectures, such as device precision, crossbar size,…

Hardware Architecture · Computer Science 2024-05-09 Songyun Qu , Shixin Zhao , Bing Li , Yintao He , Xuyi Cai , Lei Zhang , Ying Wang

In this paper, we propose FusionCIM, an operator-fusion-driven compute-in-memory (CIM) accelerator architecture for efficient and scalable LLM inference, with three key innovations: (1) a hybrid CIM pipeline architecture that maps QKT…

Hardware Architecture · Computer Science 2026-04-29 Zihao Xuan , Jia Chen , Yewen Li , Wei Xuan , Hegan Chen , Xiao Huo , Fengbin Tu

Pipeline Parallelism (PP) serves as a crucial technique for training Large Language Models (LLMs), owing to its capability to alleviate memory pressure from model states with relatively low communication overhead. However, in long-context…

Machine Learning · Computer Science 2025-04-22 Zhouyang Li , Yuliang Liu , Wei Zhang , Tailing Yuan , Bin Chen , Chengru Song , Di Zhang

The main advantage of Constraint Programming (CP) approaches for sequential pattern mining (SPM) is their modularity, which includes the ability to add new constraints (regular expressions, length restrictions, etc). The current best CP…

Databases · Computer Science 2016-04-06 John O. R. Aoga , Tias Guns , Pierre Schaus

Designing protein sequences that fold into a target 3-D structure, termed as the inverse folding problem, is central to protein engineering. However, it remains challenging due to the vast sequence space and the importance of local…

Quantitative Methods · Quantitative Biology 2026-03-17 Sazan Mahbub , Souvik Kundu , Eric P. Xing

Digital processing-in-memory (PIM) architectures mitigate the memory wall problem by facilitating parallel bitwise operations directly within the memory. Recent works have demonstrated their algorithmic potential for accelerating…

Hardware Architecture · Computer Science 2024-10-01 Orian Leitersdorf , Ronny Ronen , Shahar Kvatinsky

This paper presents a tutorial and review of SRAM-based Compute-in-Memory (CIM) circuits, with a focus on both Digital CIM (DCIM) and Analog CIM (ACIM) implementations. We explore the fundamental concepts, architectures, and operational…

Hardware Architecture · Computer Science 2024-11-25 Kentaro Yoshioka , Shimpei Ando , Satomi Miyagi , Yung-Chin Chen , Wenlun Zhang

Kernel approximation methods create explicit, low-dimensional kernel feature maps to deal with the high computational and memory complexity of standard techniques. This work studies a supervised kernel learning methodology to optimize such…

Machine Learning · Computer Science 2020-02-17 Mert Al , Zejiang Hou , Sun-Yuan Kung

Machine learning (ML) models, such as SVM, for tasks like classification and clustering of sequences, require a definition of distance/similarity between pairs of sequences. Several methods have been proposed to compute the similarity…

Machine Learning · Computer Science 2022-09-13 Sarwan Ali , Bikram Sahoo , Muhammad Asad Khan , Alexander Zelikovsky , Imdad Ullah Khan , Murray Patterson

This paper presents PRIMAL, a processing-in-memory (PIM) based large language model (LLM) inference accelerator with low-rank adaptation (LoRA). PRIMAL integrates heterogeneous PIM processing elements (PEs), interconnected by 2D-mesh…

Hardware Architecture · Computer Science 2026-01-21 Yue Jiet Chong , Yimin Wang , Zhen Wu , Xuanyao Fong

The objective of this study is to illustrate the process of training a Deep Neural Network (DNN) within a Resistive RAM (ReRAM) Crossbar-based simulation environment using CrossSim, an Application Programming Interface (API) developed for…

Hardware Architecture · Computer Science 2024-09-02 Tejaswanth Reddy Maram , Ria Barnwal , Bindu B

While machine learning (ML) interatomic potentials (IPs) are able to achieve accuracies nearing the level of noise inherent in the first-principles data to which they are trained, it remains to be shown if their increased complexities are…

Materials Science · Physics 2023-10-05 Joshua A. Vita , Dallas R. Trinkle
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