Related papers: Coded Aperture and Compton Imaging for the Develop…
Targeted alpha-particle therapy (TAT) employs alpha-emitting radionuclides conjugated to tumor-targeting molecules to deliver localized radiation to cancer cells, showing great promise in treating metastatic cancers. Among these…
In this study, we introduce a Compton SPECT system for whole-body imaging of Actinium-225 (225Ac), one of the trending radionuclides for targeted alpha therapy (TAT). The Compton SPECT system enables multi-energy gamma photon detection with…
Targeted Alpha Therapy potentially offers a more specific action in killing tumor cells and less damage to neighbouring normal cells compared to $\beta$-emitters. $^{225}$Ac along with three other $\alpha$-emitting daughter nuclei…
Tomographic imaging with radionuclides commonly used in nuclear medicine, such as $^{111}$In (171 and 245 keV) and $^{131}$I (364 keV), is in high demand for medical applications and small animal imaging. The Si/CdTe Compton camera with its…
We present a new theoretical approach to attosecond laser-assisted photo- and Compton ionization. Attosecond x-ray absorption and scattering are described by $\hat{\mathrsfs{S}}^{(1,2)}$-matrices, which are coherent superpositions of…
A future mission in medium-energy gamma-ray astrophysics would allow for many scientific advancements, e.g. a possible explanation for the excess positron emission from the Galactic Center, a better understanding of nucleosynthesis and…
Coded Aperture Imaging (CAI) has been proposed as an alternative collimation technique in nuclear imaging. To maximize spatial resolution small pinholes in the coded aperture mask are required. However, a high-resolution detector is needed…
There has been growing clinical evidence of the value of targeted alpha therapy for treatment of several cancers. The work has been slowed by the lack of availability of the key alpha emitting isotopes, especially Ac-225. Until this time,…
Photon-counting computed tomography (PCCT) marks a significant advancement over conventional energy-integrating detector (EID) CT systems. This review highlights PCCT's superior spatial and contrast resolution, reduced radiation dose, and…
Targeted Radionuclide Therapy (TRT) is a well-established technique for cancer treatment. In this approach, radionuclides are bound to specific drugs that selectively transport them to the tumor site. Within the ISOLPHARM project, a…
Radiotherapy requires precise segmentation of organs at risk (OARs) and of the Clinical Target Volume (CTV) to maximize treatment efficacy and minimize toxicity. While deep learning (DL) has significantly advanced automatic contouring,…
3C 223 is a radio loud, Type 2 quasar at $z=0.1365$ with an intriguing XMM-Newton spectrum that implicated it as a rare, Compton-thick ($N_{\rm H} \gtrsim 1.25 \times 10^{24}$ cm$^{-2}$) active galactic nucleus (AGN). We obtained…
The Advanced Compton Telescope (ACT), the next major step in gamma-ray astronomy, will probe the fires where chemical elements are formed by enabling high-resolution spectroscopy of nuclear emission from supernova explosions. During the…
Compton telescopes provide a good sensitivity over a wide field of view in the difficult energy range running from a few hundred keV to several MeV. Their angular resolution is, however, poor and strongly energy dependent. We present a…
Two major challenges in time-of-flight positron emission tomography (TOF-PET) are low spatial resolution and high radioactive dose to the patient, both of which result from limitations in detection technology rather than fundamental…
Cone beam computed tomography (CBCT) for breast imaging has potential to replace conventional mammograms. However, concerns over dose and image quality prevent CBBCT systems from the clinical trial phase to next stage. The time of flight…
Targeted Alpha Therapy (TAT) has emerged as a promising modality for the treatment of various malignancies, leveraging the high linear energy transfer (LET) and short range of alpha particles to selectively irradiate cancer cells while…
The Advanced Compton Telescope (ACT) has been suggested to be the optimal next-generation instrument to study nuclear gamma-ray lines. In this work, we investigate the potential of three hypothetical designs of the ACT to perform SN…
Objective: Proton therapy is a precision-focused cancer treatment where accurate proton beam range monitoring is critical to ensure effective dose delivery. This can be achieved by prompt gamma detection with a Compton camera like the…
For a century, clinical X-ray imaging has visualised only the attenuation properties of tissue, which fundamentally limits the contrast, particularly in soft tissues like the breast. Imaging based on refraction can overcome this limitation,…