Targeted Alpha Therapy potentially offers a more specific action in killing tumor cells and less damage to neighbouring normal cells compared to β-emitters. 225Ac along with three other α-emitting daughter nuclei 221Fr, 217At and 213Po have significant potency for clinical use. Monte carlo simulation has been carried out using MONC code for production routes of 225Ac for its possible generation using proton accelerators with Thorium-232 and Radium-226 targets. All the calculations has been carried out using global model parameters without adjusting for individual target. The study reveals that proton beam of 20-30MeV energy with 5μA current on radium-226 target can give rise to 1Ci of 225Ac activity in a week of irradiation. Thorium irradiation at low proton energy produces smaller 225Ac activity but one can benefit from high current, stable proton accelerators. Proton energy of 100MeV or above with hundreds of μA current can produce reasonable 225Ac activity for practical use. However, the contamination of other co-produced radio-isotopes is much less at low proton energy hence low energy high current proton accelerators are also viable alternative to generate Actinium-225 radio isotope.
@article{arxiv.2008.01195,
title = {Accelerator Based Production of $^{225}$Ac for Cancer Treatment},
author = {H. Kumawat and S. V. Suryanarayana},
journal= {arXiv preprint arXiv:2008.01195},
year = {2020}
}