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Positron emission tomography (PET) imaging is widely used in a number of clinical applications, including cancer and Alzheimer's disease (AD) diagnosis, monitoring of disease development, and treatment effect evaluation. Statistical…

Tissues and Organs · Quantitative Biology 2025-11-07 Akhil Ambekar , Robert Zielinski , Ani Eloyan

Time-Of-Flight (TOF) is a noble technique that is used in Positron Emission Tomography (PET) imaging worldwide. The scintillator based imaging system that is being used around the world for TOF-PET is very expensive. Multi-gap Resistive…

Instrumentation and Detectors · Physics 2018-07-02 Rajesh Ganai , Shaifali Mehta , Mehulkumar Shiroya , Mitali Mondal , Zubayer Ahammed , Subhasis Chattopadhyay

A major strength of iterative algorithms used in positron emission tomography (PET) lies in their abilities to introduce precise models of the physics at play, which includes the statistical nature of the detection processes, and a detailed…

Medical Physics · Physics 2022-04-26 Adrien Hourlier , Debora Giovagnoli , Virgile Bekaert , Frederic Boisson , David Brasse

In positron emission tomography (PET), it is indispensable to perform attenuation correction in order to obtain the quantitatively accurate activity map (tracer distribution) in the body. Generally, this is carried out based on the…

Medical Physics · Physics 2025-10-16 Liyang Hu , Chong Chen

Tau positron emission tomography (tau-PET) is an important in vivo biomarker of Alzheimer's disease, but its cost, limited availability, and acquisition burden restrict broad clinical use. This work proposes an interpretable multimodal…

Computer Vision and Pattern Recognition · Computer Science 2026-04-10 Agamdeep S. Chopra , Caitlin Neher , Tianyi Ren , Juampablo E. Heras Rivera , Hesam Jahanian , Mehmet Kurt

Time-of-flight positron emission tomography (TOF-PET) detectors exhibiting multiple coincidence time resolution (CTR) components, such as those induced by the mixing of Cherenkov and scintillation photons, have attracted increasing…

Medical Physics · Physics 2026-05-29 Kibo Ote , Fumio Hashimoto , Yuya Onishi , Ryosuke Ota , Maxime Toussaint , Francis Loignon-Houle

Low-count reconstruction remains a challenge for Positron Emission Tomography (PET) even with the recent progress in time-of-flight (TOF) resolution. In this context, the bias between the acquired histogram, consisting of low values or…

Medical Physics · Physics 2023-01-12 Maxime Toussaint , Francis Loignon-Houle , Roger Lecomte , Jean-Pierre Dussault

In this paper, we provide a novel method for the estimation of unknown parameters of the Gaussian Mixture Model (GMM) in Positron Emission Tomography (PET). A vast majority of PET imaging methods are based on reconstruction model that is…

Signal Processing · Electrical Eng. & Systems 2023-06-30 Tomislav Matulić , Damir Seršić

Positron Emission Tomography (PET) is a functional imaging modality that enables the visualization of biochemical and physiological processes across various tissues. Recently, deep learning (DL)-based methods have demonstrated significant…

Image and Video Processing · Electrical Eng. & Systems 2026-01-16 Yiran Sun , Osama Mawlawi

In Positron Emission Tomography, movement leads to blurry reconstructions when not accounted for. Whether known a priori or estimated jointly to reconstruction, motion models are increasingly defined in continuum rather that in discrete,…

Optimization and Control · Mathematics 2021-07-22 Camille Pouchol , Olivier Verdier

[$^{18}$F]fluorodeoxyglucose (FDG) positron emission tomography (PET) has emerged as a crucial tool in identifying the epileptic focus, especially in cases where magnetic resonance imaging (MRI) diagnosis yields indeterminate results. FDG…

Computer Vision and Pattern Recognition · Computer Science 2024-02-05 Wentao Chen , Jiwei Li , Xichen Xu , Hui Huang , Siyu Yuan , Miao Zhang , Tianming Xu , Jie Luo , Weimin Zhou

We perform a parametric study of the newly developed time-of-flight (TOF) image reconstruction algorithm, proposed for the real-time imaging in total-body Jagiellonian PET (J-PET) scanners. The asymmetric 3D filtering kernel is applied at…

Positron emission tomography (PET) is the most sensitive biomedical imaging modality for non-invasively detecting and visualizing positron-emitting radiopharmaceuticals within a subject. In PET, measuring the time-of-flight (TOF)…

Instrumentation and Detectors · Physics 2024-10-17 Minseok Yi , Daehee Lee , Alberto Gola , Stefano Merzi , Michele Penna , Jae Sung Lee , Simon R. Cherry , Sun Il Kwon

Positron emission tomography (PET) imaging is an imaging modality for diagnosing a number of neurological diseases. In contrast to Magnetic Resonance Imaging (MRI), PET is costly and involves injecting a radioactive substance into the…

Image and Video Processing · Electrical Eng. & Systems 2019-08-23 Haoliang Sun , Ronak Mehta , Hao H. Zhou , Zhichun Huang , Sterling C. Johnson , Vivek Prabhakaran , Vikas Singh

Photomultiplier tubes (PMTs) are widely used in particle and nuclear physics experiments. The reconstruction of PMT waveforms is a fundamental task in these experiments, where accurate extraction of photoelectron (PE) multiplicities and…

High Energy Physics - Experiment · Physics 2026-05-29 Yiming Xu , Youwen Fan , Siyu Chen , Hongyue Duyang , Teng Li , Yaoguang Wang

Positron Annihilation Lifetime Spectroscopy (PALS) has shown to be a powerful tool to study the nanostructures of porous materials. Positron Emissions Tomography (PET) are devices allowing imaging of metabolic processes e.g. in human…

Dynamic positron emission tomography (PET) images can reveal the distribution of tracers in the organism and the dynamic processes involved in biochemical reactions, and it is widely used in clinical practice. Despite the high effectiveness…

Image and Video Processing · Electrical Eng. & Systems 2025-12-22 Jie Sun , Junyan Zhang , Qian Xia , Chuanfu Sun , Yumei Chen , Yunjie Yang , Huafeng Liu , Wentao Zhu , Qiegen Liu

Positron Emission Mammography imaging system (PEMi) is a nuclear medicine diagnosis method dedicated for breast imaging. It provides a better resolution in detection of millimeter-sized breast tumors than whole-body PET. To address the…

Medical Physics · Physics 2015-10-28 Xiao-Yue Gu , Lin Li , Peng-Fei Yin , Ming-Kai Yun , Chai Pei , Xin Fan , Xian-Chao Huang , Xiao-Li Sun , Long Wei

Positron emission tomography (PET) is a classical imaging technique to reconstruct the mass distribution of a radioactive material. If the mass distribution is static, this essentially leads to inversion of the X-ray transform. However, if…

Optimization and Control · Mathematics 2023-11-30 Marco Mauritz , Bernhard Schmitzer , Benedikt Wirth