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Positron emission tomography (PET) is widely utilized for cancer detection due to its ability to visualize functional and biological processes in vivo. PET images are usually reconstructed from histogrammed raw data (sinograms) using…

Image and Video Processing · Electrical Eng. & Systems 2024-11-26 Yiran Sun , Osama Mawlawi

In oncology, Positron Emission Tomography imaging is widely used in diagnostics of cancer metastases, in monitoring of progress in course of the cancer treatment, and in planning radiotherapeutic interventions. Accurate and reproducible…

Computer Vision and Pattern Recognition · Computer Science 2016-11-01 Jakub Czakon , Filip Drapejkowski , Grzegorz Zurek , Piotr Giedziun , Jacek Zebrowski , Witold Dyrka

Positronium imaging was recently proposed to image the properties of positronium atoms in the patient body. Positronium properties depend on the size of intramolecular voids and oxygen concentration; therefore, they deliver information…

Positron Emission Particle Tracking (PEPT) is an imaging method for the visualization of fluid motion, capable of reconstructing three-dimensional trajectories of small tracer particles suspended in nearly any medium, including fluids that…

Instrumentation and Detectors · Physics 2023-03-20 Avshalom Offner , Sam Manger , Jacques Vanneste

The purpose of this study was to present image reconstruction methods for magnetic particle imaging (MPI) with a field-free-line (FFL) encoding scheme and to propose the use of the maximum likelihood-expectation maximization (ML-EM)…

Medical Physics · Physics 2016-06-13 Kenya Murase

Positronium Imaging requires two classes of events: double-coincidences originated from pair of back-to-back annihilation photons and triple-coincidences comprised with two annihilation photons and one additional prompt photon. The standard…

Medical Physics · Physics 2025-08-11 Lech Raczynski , Wojciech Krzemien , Konrad Klimaszewski

An image or volume of interest in positron emission tomography (PET) is reconstructed from pairs of gamma rays emitted from a radioactive substance. Many image reconstruction methods are based on estimation of pixels or voxels on some…

Signal Processing · Electrical Eng. & Systems 2019-06-18 Azra Tafro , Damir Seršić , Ana Sović Kržić

We present a novel analysis method for image reconstruction in emission tomography. The method, named Reconstructed Image from Simulations Ensemble (RISE), utilizes statistical physics concepts and Monte Carlo techniques to extract the…

Medical Physics · Physics 2018-04-12 Costas N. Papanicolas , Loizos Koutsantonis , Efstathios Stiliaris

Positron Annihilation Lifetime Spectroscopy (PALS) allows examining structure of materials in nano and sub-nanometer scale. This technique is based on the lifetime and intensity of ortho-positronium atoms in free volumes of given…

Medical Physics · Physics 2020-01-29 Ewelina Kubicz

Positronium-based imaging requires realistic modelling of positronium (Ps) decay in matter. We introduce a modular Ps decay model implemented in GATE 9.4 and GATE 10, enabling the definition of an arbitrary number of decay channels…

To obtain high-quality positron emission tomography (PET) while minimizing radiation exposure, a range of methods have been designed to reconstruct standard-dose PET (SPET) from corresponding low-dose PET (LPET) images. However, most…

Image and Video Processing · Electrical Eng. & Systems 2024-04-11 Yuchen Fei , Yanmei Luo , Yan Wang , Jiaqi Cui , Yuanyuan Xu , Jiliu Zhou , Dinggang Shen

Background: Positronium lifetime imaging extends conventional positron emission tomography by using the time interval between positron emission and annihilation as an additional contrast mechanism. Voxel-wise lifetime estimation in fully…

Objective: Post-traumatic epilepsy (PTE) is a debilitating neurological disorder that develops after traumatic brain injury (TBI). Early prediction of PTE remains challenging due to heterogeneous clinical data, limited positive cases, and…

Machine Learning · Computer Science 2026-04-17 Wenhui Cui , Nicholas Swingle , Anand A. Joshi , Dileep Nair , Richard M. Leahy

The integration of multimodal medical imaging can provide complementary and comprehensive information for the diagnosis of Alzheimer's disease (AD). However, in clinical practice, since positron emission tomography (PET) is often missing,…

Computational Engineering, Finance, and Science · Computer Science 2024-12-03 Fuyou Mao , Lixin Lin , Ming Jiang , Dong Dai , Chao Yang , Hao Zhang , Yan Tang

Positron Emission Tomography (PET) is a Nuclear Medicine technique that creates images that allow the study of metabolic activity and organ function using radiopharmaceuticals. Continuous improvement of scintillation detectors for radiation…

Positron emission tomography (PET) is a cornerstone of modern radiology. The ability to detect cancer and metastases in whole body scans fundamentally changed cancer diagnosis and treatment. One of the main bottlenecks in the clinical…

Computer Vision and Pattern Recognition · Computer Science 2022-04-28 Ida Häggström , C. Ross Schmidtlein , Gabriele Campanella , Thomas J. Fuchs

Single Particle Tracking (SPT) can aid in understanding complex spatio-temporal processes. However, quantifying diffusivity and forces from individual live cell trajectories is complicated by inter- & intra-trajectory kinetic heterogeneity,…

Quantitative Methods · Quantitative Biology 2016-05-19 Christopher P. Calderon

An alternating direction method of multipliers (ADMM) framework is developed for nonsmooth biconvex optimization for inverse problems in imaging. In particular, the simultaneous estimation of activity and attenuation (SAA) problem in…

Medical Physics · Physics 2024-02-13 Zhimei Ren , Emil Y. Sidky , Rina Foygel Barber , Chien-Min Kao , Xiaochuan Pan

Positron emission tomography (PET) scans expose patients to radiation, which can be mitigated by reducing the dose, albeit at the cost of diminished quality. This makes low-dose (LD) PET recovery an active research area. Previous studies…

Image and Video Processing · Electrical Eng. & Systems 2026-03-11 Ghulam Nabi Ahmad Hassan Yar , Himashi Peiris , Victoria Mar , Cameron Dennis Pain , Zhaolin Chen

The Time-of-Flight (ToF) technique coupled with semiconductor-like detectors, as silicon carbide and diamond, is one of the most promising diagnostic methods for high-energy, high repetition rate, laser-accelerated ions allowing a full…