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With almost 50% of annual commercial drug approvals being Personalised Medicine (PM) and its huge potential to improve quality of life, this emerging medical sector has received increased attention from the industry and medical research,…
In this study, two proton beam delivery designs, passive scattering proton therapy (PSPT) and pencil beam scanning (PBS), were quantitatively compared in terms of dosimetric indices. The GATE Monte Carlo code was used to simulate the proton…
Wireless power transfer (WPT) is a promising solution to provide convenient and perpetual energy supplies to electronics. Traditional WPT technologies face the challenge of providing Watt-level power over meter-level distance for Internet…
This article reviews the evolving field of radiobiology, emphasizing the need for advanced multiscale, mechanistic models to optimize radiopharmaceutical therapies (RPT). While the traditional linear-quadratic (LQ) model underpins external…
Purpose: Fast kV-switching (FKS) and dual-layer flat-panel detector (DL-FPD) technologies have been actively studied as promising dual-energy solutions for FPD-based cone-beam computed tomography (CBCT). However, CBCT spectral imaging is…
The future of ART in head and neck cancer is just beginning. Novel technologies have pushed the boundary of what is possible in terms of techniques to identify biomarkers for adaptation as well as innovative devices specialized to respond…
Low-dose computed tomography (LDCT) is an important topic in the field of radiology over the past decades. LDCT reduces ionizing radiation-induced patient health risks but it also results in a low signal-to-noise ratio (SNR) and a potential…
Beam loading is the phenomenon which limits the charge and the beam quality in plasma based accelerators. An experimental study conducted with a laser-plasma accelerator is presented. Beam loading manifests itself through the decrease of…
Medical diagnosis is a crucial task in the medical field, in terms of providing accurate classification and respective treatments. Having near-precise decisions based on correct diagnosis can affect a patient's life itself, and may…
Predictive dosimetry is central to enabling personalized radiopharmaceutical therapy (RPT), particularly in prostate specific membrane antigen (PSMA) targeted theranostics. In this work, we develop a three layer computational framework that…
Non-linear effects in accelerator physics are important for both successful operation of accelerators and during the design stage. Since both of these aspects are closely related, they will be treated together in this overview. Some of the…
We propose a new approach to high-intensity relativistic laser-driven electron acceleration in a plasma. Here, we demonstrate that a plasma wave generated by a stimulated forward-scattering of an incident laser pulse can be in the longest…
Individualized treatment rules (ITR) can improve health outcomes by recognizing that patients may respond differently to treatment and assigning therapy with the most desirable predicted outcome for each individual. Flexible and efficient…
The widespread use of high energy particle beams in basic research, medicine and coherent X-ray generation coupled with the large size of modern radio frequency (RF) accelerator devices and facilities has motivated a strong need for…
Plasma accelerators driven by intense laser or particle beams provide gigavolt-per-meter accelerating fields, promising to drastically shrink particle accelerators for high-energy physics and photon science. Applications such as linear…
In oncology, treating cancer with a beam of photons is a well established therapeutic technique, developed over 100 years, and today over 50% of cancer patients will undergo traditional X-ray radiotherapy. However, ionizing radiation…
Purpose: To describe a concept of a compact electron accelerator for external radiation therapy with variable energy in the range of 6 - 20 MeV, based on linotron principle. Methods: Beam dynamics simulation using the CST and MAD-X code.…
Large energy acceptance arcs have been proposed for applications such as cancer therapy, muon accelerators, and recirculating linacs. The efficacy of charged particle therapy can be improved by reducing the energy layer switching time,…
The human aorta is a high-risk area for vascular diseases, which are commonly restored by thoracic endovascular aortic repair. In this paper, we report a promising shear-activated targeted nanoparticle drug delivery strategy to assist in…
One of the most severe limitations in particle accelerators and beam transport are non-linear effects. Techniques to study and possibly suppress some of these detrimental effects exist, the most popular are based on particle tracking and…