Related papers: Future Developments in Charged Particle Therapy: I…
FLASH-RT has proven beneficial in preclinical studies. However, the lack of accurate real time 2D dosimetry is a limiting factor. In this work, an innovative solution for 2D real time dosimetry in UHDR electron beams is presented. The…
Objective. As proton arc therapy (PAT) approaches clinical implementation, optimizing treatment plans for this innovative delivery modality remains challenging, especially in addressing arc delivery time. Existing algorithms for minimizing…
Evolutionary algorithms have long been used for optimization problems where the appropriate size of solutions is unclear a priori. The applicability of this methodology is here investigated on the problem of designing a nano-particle (NP)…
Ion beam therapy should be "democratized" through model-based patient selection, innovative technologies for better and faster treatment delivery, and substantial size and cost reduction. The disability-adjusted life year (DALY) concept can…
A work recently published experimentally demonstrates an increase in the radiobiological efficacy of clinical proton beams when a tumour is treated in the presence of a concentration of 11B. The paper, for the first time, demonstrates the…
The electrostatic charge density of particles is of paramount importance for the control of the dispersion stability. Conventional methods use potentiometric, conductometric or turbidity titration but require large amount of samples. Here…
Achieving high-quality electron beams from laser wakefield accelerators critically relies on density tailoring to control electron dynamics during injection, acceleration, and extraction. We report on the experimental observation of…
Understanding the behaviour of the confined fast ions is important in both current and future fusion experiments. These ions play a key role in heating the plasma and will be crucial for achieving conditions for burning plasma in next-step…
Accurate models of clinical actions and their impacts on disease progression are critical for estimating personalized optimal dynamic treatment regimes (DTRs) in medical/health research, especially in managing chronic conditions.…
Background: With the advent of Intensity Modulated Radiotherapy (IMRT) and recently, Volumetric Modulated Arc Therapy (VMAT), treatment planning using Flattening Filter Free (FFF) beams can meet all of the energy requirements in radiation…
PET imaging is widely employed for observing biological metabolic activities within the human body. However, numerous benign conditions can cause increased uptake of radiopharmaceuticals, confounding differentiation from malignant tumors.…
Particle accelerators have enabled forefront research in high energy physics and other research areas for more than half a century. Accelerators have directly contributed to 26 Nobel Prizes in Physics since 1939 as well as another 20 Nobel…
Laser plasma accelerators have the potential to reduce the size of future linacs for high energy physics by more than an order of magnitude, due to their high gradient. Research is in progress at current facilities, including the BELLA…
Intracellular delivery of biomolecules remains a critical challenge in both basic cell biology and translational therapeutics. We introduce Programmable Acoustic Standing-wave Transfection (PAST), a microfluidic tool that leverages…
Proton arc therapy (PAT) has emerged as a promising approach for improving dose distribution, but also enabling simpler and faster treatment delivery in comparison to conventional proton treatments. However, the delivery speed achievable in…
We propose an on-chip optical power delivery system for dielectric laser accelerators based on a fractal 'tree-branch' dielectric waveguide network. This system replaces experimentally demanding free-space manipulations of the driving laser…
Radiotherapy is one of the main methods in the successful treatment of cancer. The tumor is irradiated with photons or charged particles (e.g. protons), and in the case of massive charged particles, the treatment results in less unnecessary…
The rapid development of chargeable devices has caused a great deal of interest in efficient and stable wireless power transfer (WPT) solutions. Most conventional WPT technologies exploit outdated electromagnetic field control methods…
The growing demand for personalized decision-making has led to a surge of interest in estimating the Conditional Average Treatment Effect (CATE). Various types of CATE estimators have been developed with advancements in machine learning and…
Radiotherapy planning is a critical aspect of cancer treatment, where the optimal selection of beam directions and dose distributions significantly impacts treatment efficacy and patient outcomes. Traditionally, this process involves…