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Accurate extraction of Alzheimer's Disease and Related Dementias (ADRD) phenotypes from electronic health records (EHR) is critical for early-stage detection and disease staging. However, this information is usually embedded in unstructured…

Artificial Intelligence · Computer Science 2026-03-17 Mingchen Shao , Yuzhang Xie , Carl Yang , Jiaying Lu

This article reviews recent advances in applying natural language processing (NLP) to Electronic Health Records (EHRs) for computational phenotyping. NLP-based computational phenotyping has numerous applications including diagnosis…

Computation and Language · Computer Science 2018-06-18 Zexian Zeng , Yu Deng , Xiaoyu Li , Tristan Naumann , Yuan Luo

We currently observe a disconcerting phenomenon in machine learning studies in psychiatry: While we would expect larger samples to yield better results due to the availability of more data, larger machine learning studies consistently show…

On the increase of major depressive disorders (MDD), many researchers paid attention to their recognition and treatment. Existing MDD recognition algorithms always use a single time-frequency domain method method, but the single…

Neurons and Cognition · Quantitative Biology 2021-11-03 Xiaofang Sun , Xiangwei Zheng , Yonghui Xu , Lizhen Cui , Bin Hu

Clinical interactions are initially recorded and documented in free text medical notes. ICD coding is the task of classifying and coding all diagnoses, symptoms and procedures associated with a patient's visit. The process is often manual…

Information Retrieval · Computer Science 2020-06-09 Zachariah Zhang , Jingshu Liu , Narges Razavian

Objective: The generalizability of clinical large language models is usually ignored during the model development process. This study evaluated the generalizability of BERT-based clinical NLP models across different clinical settings…

Computation and Language · Computer Science 2023-03-16 Sicheng Zhou , Nan Wang , Liwei Wang , Ju Sun , Anne Blaes , Hongfang Liu , Rui Zhang

In this paper, we aimed at reviewing several different approaches present today in the search for more accurate diagnostic and treatment management in mental healthcare. Our focus is on mood disorders, and in particular on the major…

Neurons and Cognition · Quantitative Biology 2019-03-28 Milena Cukic Radenkovic

Depression has affected millions of people worldwide and has become one of the most common mental disorders. Early mental disorder detection can reduce costs for public health agencies and prevent other major comorbidities. Additionally,…

Computation and Language · Computer Science 2024-04-09 Giuliano Lorenzoni , Cristina Tavares , Nathalia Nascimento , Paulo Alencar , Donald Cowan

In disentangling the heterogeneity observed in psychopathology, personality of the patients is considered crucial. While it has been demonstrated that personality traits are reflected in the language used by a patient, we hypothesize that…

Computation and Language · Computer Science 2023-11-08 Semere Kiros Bitew , Vincent Schelstraete , Klim Zaporojets , Kimberly Van Nieuwenhove , Reitske Meganck , Chris Develder

Objective: We develop a deep learning framework based on the pre-trained Bidirectional Encoder Representations from Transformers (BERT) model using unstructured clinical notes from electronic health records (EHRs) to predict the risk of…

Accurate and interpretable detection of depressive language in social media is useful for early interventions of mental health conditions, and has important implications for both clinical practice and broader public health efforts. In this…

Computation and Language · Computer Science 2025-06-10 Samuel Kim , Oghenemaro Imieye , Yunting Yin

In this study, we focus on automated approaches to detect depression from clinical interviews using multi-modal machine learning (ML). Our approach differentiates from other successful ML methods such as context-aware analysis through…

Machine Learning · Computer Science 2024-12-30 Genevieve Lam , Huang Dongyan , Weisi Lin

Driven by privacy protection laws and regulations, unlearning in Large Language Models (LLMs) is gaining increasing attention. However, current research often neglects the interpretability of the unlearning process, particularly concerning…

Machine Learning · Computer Science 2025-04-10 Xiaohua Feng , Yuyuan Li , Chengye Wang , Junlin Liu , Li Zhang , Chaochao Chen

Dementia is associated with language disorders which impede communication. Here, we automatically learn linguistic disorder patterns by making use of a moderately-sized pre-trained language model and forcing it to focus on reformulated…

Computation and Language · Computer Science 2023-10-17 Dimitris Gkoumas , Matthew Purver , Maria Liakata

The Bidirectional Encoder Representations from Transformers (BERT) model has achieved the state-of-the-art performance for many natural language processing (NLP) tasks. Yet, limited research has been contributed to studying its…

Computation and Language · Computer Science 2021-09-23 Zimin Wan , Chenchen Xu , Hanna Suominen

Large-scale clinical data is invaluable to driving many computational scientific advances today. However, understandable concerns regarding patient privacy hinder the open dissemination of such data and give rise to suboptimal siloed…

Computation and Language · Computer Science 2019-05-23 Oren Melamud , Chaitanya Shivade

Depression is a globally prevalent mental disorder with potentially severe repercussions if not addressed, especially in individuals with recurrent episodes. Prior research has shown that early intervention has the potential to mitigate or…

Computation and Language · Computer Science 2024-09-16 Hossein Salahshoor Gavalan , Mohmmad Naim Rastgoo , Bahareh Nakisa

Clinical patient notes are critical for documenting patient interactions, diagnoses, and treatment plans in medical practice. Ensuring accurate evaluation of these notes is essential for medical education and certification. However, manual…

Computation and Language · Computer Science 2024-01-25 Jingyu Xu , Yifeng Jiang , Bin Yuan , Shulin Li , Tianbo Song

In the digital era, the prevalence of depressive symptoms expressed on social media has raised serious concerns, necessitating advanced methodologies for timely detection. This paper addresses the challenge of interpretable depression…

Computation and Language · Computer Science 2025-07-10 Loris Belcastro , Riccardo Cantini , Fabrizio Marozzo , Domenico Talia , Paolo Trunfio

Introduction: Identifying neurobiological differences between patients suffering from Major Depressive Disorder (MDD) and healthy individuals has been a mainstay of clinical neuroscience for decades. However, recent meta- and mega-analyses…