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Background Major depressive disorder (MDD) is a leading cause of global disability, yet current diagnostic approaches often rely on subjective assessments and lack the ability to integrate multimodal clinical information. Large language…

Machine Learning · Computer Science 2025-09-30 Yuyang Sha , Hongxin Pan , Gang Luo , Caijuan Shi , Jing Wang , Kefeng Li

A fundamental component of user-level social media language based clinical depression modelling is depression symptoms detection (DSD). Unfortunately, there does not exist any DSD dataset that reflects both the clinical insights and the…

Computation and Language · Computer Science 2022-09-30 Nawshad Farruque , Randy Goebel , Sudhakar Sivapalan , Osmar Zaiane

Major Depressive Disorder (MDD) is a severe illness that affects millions of people, and it is critical to diagnose this disorder as early as possible. Detecting depression from voice signals can be of great help to physicians and can be…

Audio and Speech Processing · Electrical Eng. & Systems 2022-06-28 Jinhan Wang , Vijay Ravi , Jonathan Flint , Abeer Alwan

Recent advancements in NLP have spurred significant interest in analyzing social media text data for identifying linguistic features indicative of mental health issues. However, the domain of Expressive Narrative Stories (ENS)-deeply…

Computation and Language · Computer Science 2025-01-28 Jinwen Tang , Qiming Guo , Yunxin Zhao , Yi Shang

Delirium is an acute decline or fluctuation in attention, awareness, or other cognitive function that can lead to serious adverse outcomes. Despite the severe outcomes, delirium is frequently unrecognized and uncoded in patients' electronic…

Diabetic eye disease is a major cause of blindness worldwide. The ability to monitor relevant clinical trajectories and detect lapses in care is critical to managing the disease and preventing blindness. Alas, much of the information…

Computation and Language · Computer Science 2023-11-16 Keith Harrigian , Tina Tang , Anthony Gonzales , Cindy X. Cai , Mark Dredze

This paper compares the effectiveness of traditional machine learning methods, encoder-based models, and large language models (LLMs) on the task of detecting depression and anxiety. Five Russian-language datasets were considered, each…

Computation and Language · Computer Science 2025-11-04 Gleb Kuzmin , Petr Strepetov , Maksim Stankevich , Natalia Chudova , Artem Shelmanov , Ivan Smirnov

Rare diseases (RDs) are collectively common and affect 300 million people worldwide. Accurate phenotyping is critical for informing diagnosis and treatment, but RD phenotypes are often embedded in unstructured text and time-consuming to…

Computation and Language · Computer Science 2024-06-28 Cathy Shyr , Yan Hu , Paul A. Harris , Hua Xu

Motivation: A perennial challenge for biomedical researchers and clinical practitioners is to stay abreast with the rapid growth of publications and medical notes. Natural language processing (NLP) has emerged as a promising direction for…

Computation and Language · Computer Science 2021-12-16 Robert Tinn , Hao Cheng , Yu Gu , Naoto Usuyama , Xiaodong Liu , Tristan Naumann , Jianfeng Gao , Hoifung Poon

We hypothesize that large language models (LLMs) based on the transformer architecture can enable automated detection of clinical phenotype terms, including terms not documented in the HPO. In this study, we developed two types of models:…

Quantitative Methods · Quantitative Biology 2023-11-10 Jingye Yang , Cong Liu , Wendy Deng , Da Wu , Chunhua Weng , Yunyun Zhou , Kai Wang

Machine learning (ML) techniques have gained popularity in the neuroimaging field due to their potential for classifying neuropsychiatric disorders. However, the diagnostic predictive power of the existing algorithms has been limited by…

Major depressive disorder (MDD) is a complex psychiatric disorder that affects the lives of hundreds of millions of individuals around the globe. Even today, researchers debate if morphological alterations in the brain are linked to MDD,…

Quantitative Methods · Quantitative Biology 2025-01-27 Roberto Goya-Maldonado , Tracy Erwin-Grabner , Ling-Li Zeng , Christopher R. K. Ching , Andre Aleman , Alyssa R. Amod , Zeynep Basgoze , Francesco Benedetti , Bianca Besteher , Katharina Brosch , Robin Bülow , Romain Colle , Colm G. Connolly , Emmanuelle Corruble , Baptiste Couvy-Duchesne , Kathryn Cullen , Udo Dannlowski , Christopher G. Davey , Annemiek Dols , Jan Ernsting , Jennifer W. Evans , Lukas Fisch , Paola Fuentes-Claramonte , Ali Saffet Gonul , Ian H. Gotlib , Hans J. Grabe , Nynke A. Groenewold , Dominik Grotegerd , Tim Hahn , J. Paul Hamilton , Laura K. M. Han , Ben J. Harrison , Tiffany C. Ho , Neda Jahanshad , Alec J. Jamieson , Andriana Karuk , Tilo Kircher , Bonnie Klimes-Dougan , Sheri-Michelle Koopowitz , Thomas Lancaster , Ramona Leenings , Meng Li , David E. J. Linden , Frank P. MacMaster , David M. A. Mehler , Susanne Meinert , Elisa Melloni , Bryon A. Mueller , Benson Mwangi , Igor Nenadić , Amar Ojha , Yasumasa Okamoto , Mardien L. Oudega , Brenda W. J. H. Penninx , Sara Poletti , Edith Pomarol-Clotet , Maria J. Portella , Elena Pozzi , Joaquim Radua , Elena Rodríguez-Cano , Matthew D. Sacchet , Raymond Salvador , Anouk Schrantee , Kang Sim , Jair C. Soares , Aleix Solanes , Dan J. Stein , Frederike Stein , Aleks Stolicyn , Sophia I. Thomopoulos , Yara J. Toenders , Aslihan Uyar-Demir , Eduard Vieta , Yolanda Vives-Gilabert , Henry Völzke , Martin Walter , Heather C. Whalley , Sarah Whittle , Nils Winter , Katharina Wittfeld , Margaret J. Wright , Mon-Ju Wu , Tony T. Yang , Carlos Zarate , Dick J. Veltman , Lianne Schmaal , Paul M. Thompson

The Early diagnosis and treatment of depression is essential for effective treatment. Depression, while being one of the most common mental illnesses, is still poorly understood in both research and clinical practice. Among different…

Signal Processing · Electrical Eng. & Systems 2023-03-13 Abdolkarim Saeedi , Arash Maghsoudi , Fereidoun Nowshiravan Rahatabad

Deep phenotyping is the detailed description of patient signs and symptoms using concepts from an ontology. The deep phenotyping of the numerous physician notes in electronic health records requires high throughput methods. Over the past…

Computation and Language · Computer Science 2024-03-12 Syed I. Munzir , Daniel B. Hier , Michael D. Carrithers

Depression is ranked as the largest contributor to global disability and is also a major reason for suicide. Still, many individuals suffering from forms of depression are not treated for various reasons. Previous studies have shown that…

Computation and Language · Computer Science 2024-10-30 Marcel Trotzek , Sven Koitka , Christoph M. Friedrich

Major depressive disorder (MDD) is a prevalent mental disorder associated with complex neurobiological changes that cannot be fully captured using a single imaging modality. The use of multimodal magnetic resonance imaging (MRI) provides a…

Computer Vision and Pattern Recognition · Computer Science 2026-04-14 Nojod M. Alotaibi , Areej M. Alhothali

This research delves into Musculoskeletal Disorder (MSD) risk factors, using a blend of Natural Language Processing (NLP) and mode-based ranking. The aim is to refine understanding, classification, and prioritization for focused prevention…

Computation and Language · Computer Science 2024-11-06 Md Abrar Jahin , Subrata Talapatra

Although rare diseases are characterized by low prevalence, approximately 300 million people are affected by a rare disease. The early and accurate diagnosis of these conditions is a major challenge for general practitioners, who do not…

Computation and Language · Computer Science 2021-11-12 Isabel Segura-Bedmar , David Camino-Perdonas , Sara Guerrero-Aspizua

Depression is a major global public health challenge and its early identification is crucial. Social media data provides a new perspective for depression detection, but existing methods face limitations such as insufficient accuracy,…

Artificial Intelligence · Computer Science 2026-01-12 Yukun Yang

Objective: We investigate whether deep learning techniques for natural language processing (NLP) can be used efficiently for patient phenotyping. Patient phenotyping is a classification task for determining whether a patient has a medical…