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A key challenge in cancer immunotherapy biomarker research is quantification of pattern changes in microscopic whole slide images of tumor biopsies. Different cell types tend to migrate into various tissue compartments and form variable…

Computer Vision and Pattern Recognition · Computer Science 2018-09-25 Amal Lahiani , Jacob Gildenblat , Irina Klaman , Nassir Navab , Eldad Klaiman

Artificial intelligence and machine learning techniques have the promise to revolutionize the field of digital pathology. However, these models demand considerable amounts of data, while the availability of unbiased training data is…

Image and Video Processing · Electrical Eng. & Systems 2023-02-14 Nati Daniel , Eliel Aknin , Ariel Larey , Yoni Peretz , Guy Sela , Yael Fisher , Yonatan Savir

With the advent of digital scanners and deep learning, diagnostic operations may move from a microscope to a desktop. Hematoxylin and Eosin (H&E) staining is one of the most frequently used stains for disease analysis, diagnosis, and…

Computer Vision and Pattern Recognition · Computer Science 2023-08-28 Shikha Dubey , Tushar Kataria , Beatrice Knudsen , Shireen Y. Elhabian

An important part of Digital Pathology is the analysis of multiple digitised whole slide images from differently stained tissue sections. It is common practice to mount consecutive sections containing corresponding microscopic structures on…

Computer Vision and Pattern Recognition · Computer Science 2018-11-06 Thomas Lampert , Odyssée Merveille , Jessica Schmitz , Germain Forestier , Friedrich Feuerhake , Cédric Wemmert

Stain variation is a phenomenon observed when distinct pathology laboratories stain tissue slides that exhibit similar but not identical color appearance. Due to this color shift between laboratories, convolutional neural networks (CNNs)…

Computer Vision and Pattern Recognition · Computer Science 2020-04-16 David Tellez , Geert Litjens , Peter Bandi , Wouter Bulten , John-Melle Bokhorst , Francesco Ciompi , Jeroen van der Laak

Deep Neural Networks (DNNs) are vulnerable to adversarial attacks, which pose security challenges to hyperspectral image (HSI) classification based on DNNs. Numerous adversarial attack methods have been designed in the domain of natural…

Computer Vision and Pattern Recognition · Computer Science 2025-08-20 Chun Liu , Bingqian Zhu , Tao Xu , Zheng Zheng , Zheng Li , Wei Yang , Zhigang Han , Jiayao Wang

This paper presents a novel method to deal with the challenging task of generating photographic images conditioned on semantic image descriptions. Our method introduces accompanying hierarchical-nested adversarial objectives inside the…

Computer Vision and Pattern Recognition · Computer Science 2018-04-10 Zizhao Zhang , Yuanpu Xie , Lin Yang

The detection of nuclei is one of the most fundamental components of computational pathology. Current state-of-the-art methods are based on deep learning, with the prerequisite that extensive labeled datasets are available. The increasing…

Image and Video Processing · Electrical Eng. & Systems 2019-07-11 Nicolas Brieu , Armin Meier , Ansh Kapil , Ralf Schoenmeyer , Christos G. Gavriel , Peter D. Caie , Günter Schmidt

It is common for pathologists to annotate specific regions of the tissue, such as tumor, directly on the glass slide with markers. Although this practice was helpful prior to the advent of histology whole slide digitization, it often…

Computer Vision and Pattern Recognition · Computer Science 2019-10-16 Bairavi Venkatesh , Tosha Shah , Antong Chen , Soheil Ghafurian

The adversarial methods showed advanced performance by producing synthetic images to mitigate the domain shift, a common problem due to the hardship of acquiring labelled data in medical field. Most existing studies focus on modifying the…

Image and Video Processing · Electrical Eng. & Systems 2023-05-09 Xinwen Zhang , Chaoyi Zhang , Dongnan Liu , Qianbi Yu , Weidong Cai

In this paper we propose a new augmentation technique, called patch augmentation, that, in our experiments, improves model accuracy and makes networks more robust to adversarial attacks. In brief, this data-independent approach creates new…

Computer Vision and Pattern Recognition · Computer Science 2019-11-26 Marcus D. Bloice , Peter M. Roth , Andreas Holzinger

Recent studies on unsupervised image-to-image translation have made a remarkable progress by training a pair of generative adversarial networks with a cycle-consistent loss. However, such unsupervised methods may generate inferior results…

Computer Vision and Pattern Recognition · Computer Science 2018-07-31 Minjun Li , Haozhi Huang , Lin Ma , Wei Liu , Tong Zhang , Yu-Gang Jiang

Fine-tuning through knowledge transfer from a pre-trained model on a large-scale dataset is a widely spread approach to effectively build models on small-scale datasets. In this work, we show that a recent adversarial attack designed for…

Machine Learning · Computer Science 2021-04-30 Ting-Wu Chin , Cha Zhang , Diana Marculescu

Deep neural networks are vulnerable to adversarial examples crafted by applying human-imperceptible perturbations on clean inputs. Although many attack methods can achieve high success rates in the white-box setting, they also exhibit weak…

Computer Vision and Pattern Recognition · Computer Science 2023-08-22 Zhijin Ge , Fanhua Shang , Hongying Liu , Yuanyuan Liu , Liang Wan , Wei Feng , Xiaosen Wang

Data augmentation has proved extremely useful by increasing training data variance to alleviate overfitting and improve deep neural networks' generalization performance. In medical image analysis, a well-designed augmentation policy usually…

Computer Vision and Pattern Recognition · Computer Science 2021-03-31 Yunhe Gao , Zhiqiang Tang , Mu Zhou , Dimitris Metaxas

Deep learning based medical image recognition systems often require a substantial amount of training data with expert annotations, which can be expensive and time-consuming to obtain. Recently, synthetic augmentation techniques have been…

Computer Vision and Pattern Recognition · Computer Science 2023-08-09 Jiarong Ye , Haomiao Ni , Peng Jin , Sharon X. Huang , Yuan Xue

Digitized pathological diagnosis has been in increasing demand recently. It is well known that color information is critical to the automatic and visual analysis of pathological slides. However, the color variations due to various factors…

Image and Video Processing · Electrical Eng. & Systems 2024-02-13 Shaojin Cai , Yuyang Xue3 Qinquan Gao , Min Du , Gang Chen , Hejun Zhang , Tong Tong

In medical image diagnosis, pathology image analysis using semantic segmentation becomes important for efficient screening as a field of digital pathology. The spatial augmentation is ordinary used for semantic segmentation. Tumor images…

Machine Learning · Computer Science 2021-03-04 Takato Yasuno

The creation of in-silico datasets can expand the utility of existing annotations to new domains with different staining patterns in computational pathology. As such, it has the potential to significantly lower the cost associated with…

Image and Video Processing · Electrical Eng. & Systems 2024-03-12 Dominik Winter , Nicolas Triltsch , Philipp Plewa , Marco Rosati , Thomas Padel , Ross Hill , Markus Schick , Nicolas Brieu

Automatic and accurate Gleason grading of histopathology tissue slides is crucial for prostate cancer diagnosis, treatment, and prognosis. Usually, histopathology tissue slides from different institutions show heterogeneous appearances…

Computer Vision and Pattern Recognition · Computer Science 2018-06-08 Jian Ren , Ilker Hacihaliloglu , Eric A. Singer , David J. Foran , Xin Qi