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In medical diagnostics, accurate uncertainty estimation for neural-based models is essential for complementing second-opinion systems. Despite neural network ensembles' proficiency in this problem, a gap persists between actual…

Computer Vision and Pattern Recognition · Computer Science 2024-07-17 Ekaterina Zaychenkova , Dmitrii Iarchuk , Sergey Korchagin , Alexey Zaitsev , Egor Ershov

In this paper, we consider a new low-quality label learning problem: learning time series detection models from temporally imprecise labels. In this problem, the data consist of a set of input time series, and supervision is provided by a…

Machine Learning · Statistics 2017-04-14 Roy J. Adams , Benjamin M. Marlin

Cell detection is the task of detecting the approximate positions of cell centroids from microscopy images. Recently, convolutional neural network-based approaches have achieved promising performance. However, these methods require a…

Computer Vision and Pattern Recognition · Computer Science 2021-07-20 Kazuya Nishimura , Hyeonwoo Cho , Ryoma Bise

The complexities inherent to leukemia, multifaceted cancer affecting white blood cells, pose considerable diagnostic and treatment challenges, primarily due to reliance on laborious morphological analyses and expert judgment that are…

Label-free approaches are attractive in cytological imaging due to their flexibility and cost efficiency. They are supported by machine learning methods, which, despite the lack of labeling and the associated lower contrast, can classify…

Computer Vision and Pattern Recognition · Computer Science 2023-11-27 Stefan Röhrl , Johannes Groll , Manuel Lengl , Simon Schumann , Christian Klenk , Dominik Heim , Martin Knopp , Oliver Hayden , Klaus Diepold

Class distribution plays an important role in learning deep classifiers. When the proportion of each class in the test set differs from the training set, the performance of classification nets usually degrades. Such a label distribution…

Image and Video Processing · Electrical Eng. & Systems 2022-07-12 Wenao Ma , Cheng Chen , Shuang Zheng , Jing Qin , Huimao Zhang , Qi Dou

Single-cell datasets often lack individual cell labels, making it challenging to identify cells associated with disease. To address this, we introduce Mixture Modeling for Multiple Instance Learning (MMIL), an expectation maximization…

Quantitative Methods · Quantitative Biology 2024-06-13 Erin Craig , Timothy Keyes , Jolanda Sarno , Maxim Zaslavsky , Garry Nolan , Kara Davis , Trevor Hastie , Robert Tibshirani

Deep learning has achieved spectacular performance in image and speech recognition and synthesis. It outperforms other machine learning algorithms in problems where large amounts of data are available. In the area of measurement technology,…

Quantitative Methods · Quantitative Biology 2019-08-20 Yueqin Li , Ata Mahjoubfar , Claire Lifan Chen , Kayvan Reza Niazi , Li Pei , Bahram Jalali

Deep learning approaches often require huge datasets to achieve good generalization. This complicates its use in tasks like image-based medical diagnosis, where the small training datasets are usually insufficient to learn appropriate data…

Computer Vision and Pattern Recognition · Computer Science 2021-02-12 Roberto Vega , Pouneh Gorji , Zichen Zhang , Xuebin Qin , Abhilash Rakkunedeth Hareendranathan , Jeevesh Kapur , Jacob L. Jaremko , Russell Greiner

Deep neural networks are known to be data-driven and label noise can have a marked impact on model performance. Recent studies have shown great robustness to classic image recognition even under a high noisy rate. In medical applications,…

Computer Vision and Pattern Recognition · Computer Science 2021-03-23 Lie Ju , Xin Wang , Lin Wang , Dwarikanath Mahapatra , Xin Zhao , Mehrtash Harandi , Tom Drummond , Tongliang Liu , Zongyuan Ge

Cell detection is an essential task in cell image analysis. Recent deep learning-based detection methods have achieved very promising results. In general, these methods require exhaustively annotating the cells in an entire image. If some…

Computer Vision and Pattern Recognition · Computer Science 2021-07-22 Kazuma Fujii , Daiki Suehiro , Kazuya Nishimura , Ryoma Bise

Segmentation of pathological images is essential for accurate disease diagnosis. The quality of manual labels plays a critical role in segmentation accuracy; yet, in practice, the labels between pathologists could be inconsistent, thus…

Image and Video Processing · Electrical Eng. & Systems 2021-04-07 Li Xiao , Yinhao Li , Luxi Qv , Xinxia Tian , Yijie Peng , S. Kevin Zhou

In this study, we propose a robust methodology for identification of myeloid blasts followed by prediction of genetic mutation in single-cell images of blasts, tackling challenges associated with label accuracy and data noise. We trained an…

Image and Video Processing · Electrical Eng. & Systems 2025-06-17 Garima Jain , Ravi Kant Gupta , Priyansh Jain , Abhijeet Patil , Ardhendu Sekhar , Gajendra Smeeta , Sanghamitra Pati , Amit Sethi

Automating white blood cell classification for diagnosis of leukaemia is a promising alternative to time-consuming and resource-intensive examination of cells by expert pathologists. However, designing robust algorithms for classification…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Siddharth Srivastava , Adam Smith , Scott Brooks , Jack Bacon , Till Bretschneider

Acute Lymphoblastic Leukemia (ALL) is one of the most common types of childhood blood cancer. The quick start of the treatment process is critical to saving the patient's life, and for this reason, early diagnosis of this disease is…

Computer Vision and Pattern Recognition · Computer Science 2025-03-07 Amirhossein Askari Farsangi , Ali Sharifi-Zarchi , Mohammad Hossein Rohban

Disease progression prediction based on patients' evolving health information is challenging when true disease states are unknown due to diagnostic capabilities or high costs. For example, the absence of gold-standard neurological diagnoses…

Methodology · Statistics 2024-12-12 Zexi Cai , Donglin Zeng , Karen S. Marder , Lawrence S. Honig , Yuanjia Wang

Models that can predict the occurrence of events ahead of time with low false-alarm rates are critical to the acceptance of decision support systems in the medical community. This challenging task is typically treated as a simple binary…

Machine Learning · Computer Science 2023-01-31 Hugo Yèche , Alizée Pace , Gunnar Rätsch , Rita Kuznetsova

Label-free cell classification is advantageous for supplying pristine cells for further use or examination, yet existing techniques frequently fall short in terms of specificity and speed. In this study, we address these limitations through…

Image and Video Processing · Electrical Eng. & Systems 2025-02-25 Khayrul Islam , Ratul Paul , Shen Wang , Yuwen Zhao , Partho Adhikary , Qiying Li , Xiaochen Qin , Yaling Liu

In this paper we discuss a new method for detecting leukemia in microscopic blood smear images using deep neural networks to diagnose leukemia early in blood. leukemia is considered one of the most dangerous mortality causes for a human…

Image and Video Processing · Electrical Eng. & Systems 2023-01-10 Abdelmageed Ahmed , Alaa Nagy , Ahmed Kamal , Daila Farghl

Technological and computational advances continuously drive forward the broad field of deep learning. In recent years, the derivation of quantities describing theuncertainty in the prediction - which naturally accompanies the modeling…

Machine Learning · Computer Science 2022-05-31 Christoph Koller , Göran Kauermann , Xiao Xiang Zhu
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