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Leukemia epitomizes the class of highly complex diseases that new technologies aim to tackle by using large sets of single-cell level information. Achieving such goal depends critically not only on experimental techniques but also on…

Quantitative Methods · Quantitative Biology 2014-06-02 Jose M. G. Vilar

The unstructured nature of clinical notes within electronic health records often conceals vital patient-related information, making it challenging to access or interpret. To uncover this hidden information, specialized Natural Language…

Many time series classification tasks, where labels vary over time, are affected by label noise that also varies over time. Such noise can cause label quality to improve, worsen, or periodically change over time. We first propose and…

Machine Learning · Computer Science 2025-03-18 Sujay Nagaraj , Walter Gerych , Sana Tonekaboni , Anna Goldenberg , Berk Ustun , Thomas Hartvigsen

Medical image classification is a challenging task due to the scarcity of labeled samples and class imbalance caused by the high variance in disease prevalence. Semi-supervised learning (SSL) methods can mitigate these challenges by…

Computer Vision and Pattern Recognition · Computer Science 2023-07-11 Md Junaid Mahmood , Pranaw Raj , Divyansh Agarwal , Suruchi Kumari , Pravendra Singh

Medical image segmentation is inherently uncertain. For a given image, there may be multiple plausible segmentation hypotheses, and physicians will often disagree on lesion and organ boundaries. To be suited to real-world application,…

Computer Vision and Pattern Recognition · Computer Science 2021-09-28 João Lourenço Silva , Arlindo L. Oliveira

Deep learning-based medical image classification techniques are rapidly advancing in medical image analysis, making it crucial to develop accurate and trustworthy models that can be efficiently deployed across diverse clinical scenarios.…

Computer Vision and Pattern Recognition · Computer Science 2025-06-24 Hangzhou He , Jiachen Tang , Lei Zhu , Kaiwen Li , Yanye Lu

Computer-aided diagnosis systems must make critical decisions from medical images that are often noisy, ambiguous, or conflicting, yet today's models are trained on overly simplistic labels that ignore diagnostic uncertainty. One-hot labels…

Computer Vision and Pattern Recognition · Computer Science 2025-09-16 Ang Nan Gu , Michael Tsang , Hooman Vaseli , Purang Abolmaesumi , Teresa Tsang

In medical imaging, inter-observer variability among radiologists often introduces label uncertainty, particularly in modalities where visual interpretation is subjective. Lung ultrasound (LUS) is a prime example-it frequently presents a…

Determining the trajectories of cells and their lineages or ancestries in live-cell experiments are fundamental to the understanding of how cells behave and divide. This paper proposes novel online algorithms for jointly tracking and…

Signal Processing · Electrical Eng. & Systems 2021-10-29 Tran Thien Dat Nguyen , Ba-Ngu Vo , Ba-Tuong Vo , Du Yong Kim , Yu Suk Choi

Analyzing and inspecting bone marrow cell cytomorphology is a critical but highly complex and time-consuming component of hematopathology diagnosis. Recent advancements in artificial intelligence have paved the way for the application of…

Computer Vision and Pattern Recognition · Computer Science 2022-05-23 Shayan Fazeli , Alireza Samiei , Thomas D. Lee , Majid Sarrafzadeh

Deep learning approaches exhibit promising performances on various text tasks. However, they are still struggling on medical text classification since samples are often extremely imbalanced and scarce. Different from existing mainstream…

Computation and Language · Computer Science 2023-11-29 Jiahuan Yan , Haojun Gao , Zhang Kai , Weize Liu , Danny Chen , Jian Wu , Jintai Chen

Despite fluorescent cell-labelling being widely employed in biomedical studies, some of its drawbacks are inevitable, with unsuitable fluorescent probes or probes inducing a functional change being the main limitations. Consequently, the…

Quantitative Methods · Quantitative Biology 2020-03-03 Yan Ge , Philipp Rosendahl , Claudio Durán , Nicole Töpfner , Sara Ciucci , Jochen Guck , Carlo Vittorio Cannistraci

Models have been proposed to extract temporal patterns from longitudinal electronic health records (EHR) for clinical predictive models. However, the common relations among patients (e.g., receiving the same medical treatments) were rarely…

Applications · Statistics 2019-09-27 Yue Wang , Tong Wu , Yunlong Wang , Gao Wang

High-quality data is crucial for the success of machine learning, but labeling large datasets is often a time-consuming and costly process. While semi-supervised learning can help mitigate the need for labeled data, label quality remains an…

Computer Vision and Pattern Recognition · Computer Science 2023-05-23 Lars Schmarje , Vasco Grossmann , Tim Michels , Jakob Nazarenus , Monty Santarossa , Claudius Zelenka , Reinhard Koch

Automated data labeling techniques are crucial for accelerating the development of deep learning models, particularly in complex medical imaging applications. However, ensuring accuracy and efficiency remains challenging. This paper…

Computer Vision and Pattern Recognition · Computer Science 2024-04-09 Yu-Hsi Chen

Alzheimer's Disease is challenging to diagnose due to our limited understanding of its mechanism and large heterogeneity among patients. Neurodegeneration is studied widely as a biomarker for clinical diagnosis, which can be measured from…

Machine Learning · Computer Science 2024-10-18 Rosemary He , Ichiro Takeuchi

Labeling mistakes are frequently encountered in real-world applications. If not treated well, the labeling mistakes can deteriorate the classification performances of a model seriously. To address this issue, we propose an improved Naive…

Machine Learning · Computer Science 2023-04-14 Qianhan Zeng , Yingqiu Zhu , Xuening Zhu , Feifei Wang , Weichen Zhao , Shuning Sun , Meng Su , Hansheng Wang

Medical automatic diagnosis aims to imitate human doctors in real-world diagnostic processes and to achieve accurate diagnoses by interacting with the patients. The task is formulated as a sequential decision-making problem with a series of…

Machine Learning · Computer Science 2022-06-07 Hongyi Yuan , Sheng Yu

Pathology deals with the practice of discovering the reasons for disease by analyzing the body samples. The most used way in this field, is to use histology which is basically studying and viewing microscopic structures of cell and tissues.…

Image and Video Processing · Electrical Eng. & Systems 2021-11-08 Virender Ranga , Shivam Gupta , Priyansh Agrawal , Jyoti Meena

Representing a true label as a one-hot vector is a common practice in training text classification models. However, the one-hot representation may not adequately reflect the relation between the instances and labels, as labels are often not…

Computation and Language · Computer Science 2020-12-10 Biyang Guo , Songqiao Han , Xiao Han , Hailiang Huang , Ting Lu