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Multi-pass transmission electron microscopy (MPTEM) has been proposed as a way to reduce damage to radiation-sensitive materials. For the field of cryo-electron microscopy (cryo-EM), this would significantly reduce the number of projections…

Fourier ptychographic microscopy (FPM) is a pivotal computational imaging technique that achieves phase and amplitude reconstruction with high resolution and wide field of view, using low numerical aperture objectives and LED array…

In order to efficiently image a non-absorbing sample (a phase object), dedicated phase contrast optics are required. Typically, these optics are designed with the assumption that the sample is weakly scattering, implying a linear relation…

Optics · Physics 2020-10-22 Stewart Koppell , Mark Kasevich

We demonstrate a new scheme of infrared spectroscopy with visible light sources and detectors. The technique relies on the nonlinear interference of correlated photons, produced via spontaneous parametric down conversion in a nonlinear…

We explore the potential of optical intensity interferometry to extract angularly resolved information from supernova explosions, introducing the "expanding ejecta method" (EEM) as a robust alternative to the classical expanding photosphere…

High Energy Astrophysical Phenomena · Physics 2025-04-30 I-Kai Chen , David Dunsky , Ken Van Tilburg , Junwu Huang , Robert V. Wagoner

This paper studies the mitigation of intersymbol interference in a diffusive molecular communication system using enzymes that freely diffuse in the propagation environment. The enzymes form reaction intermediates with information molecules…

Information Theory · Computer Science 2014-01-21 Adam Noel , Karen C. Cheung , Robert Schober

We provide the first demonstration that a neutron far-field interferometer can be employed to measure the microstructure of a sample. The interferometer is based on the moir\'e pattern of two phase modulating gratings which was previously…

We propose a possible approach to achieve an 1/N sensitivity of Michelson interferometer by using a properly designed random phase modulation. Different from other approaches, the sensitivity improvement does not depend on increasing…

Quantum Physics · Physics 2009-11-13 Jian Fu

We have built and operated an atom interferometer of the Mach-Zehnder type. The atomic wave is a supersonic beam of lithium seeded in argon and the mirrors and beam-splitters for the atomic wave are based on elastic Bragg diffraction on…

Quantum Physics · Physics 2016-08-16 Alain Miffre , Marion Jacquey , Matthias Büchner , Gérard Trenec , Jacques Vigue

Several techniques have been employed for the direct visualization of cytoskeletal filaments and their associated proteins. Total-internal-reflection-fluorescence (TIRF) microscopy has a high signal-to-background ratio, but it suffers from…

Biological Physics · Physics 2022-01-21 Yazgan Tuna , Amer Al-Hiyasat , Jonathon Howard

We present a new digital holographic microscope (DHM) with a low coherent source for the quantitative imaging of smooth and optically rough objects. The experimental design of the microscope uses an in-line experimental geometry based on…

FRET measurements can provide dynamic spatial information on length scales smaller than the diffraction limit of light. Several methods exist to measure FRET between fluorophores, including Fluorescence Lifetime Imaging Microscopy (FLIM),…

Quantitative Methods · Quantitative Biology 2017-01-09 Bryan Kaye , Peter J. Foster , Tae Yeon Yoo , Daniel J. Needleman

Optimal measurement scheme with an efficient data processing is important in quantum-enhanced interferometry. Here we prove that for a general binary outcome measurement, the simplest data processing based on inverting the average signal…

Quantum Physics · Physics 2014-07-11 X. M. Feng , G. R. Jin , W. Yang

Lensless digital holographic microscopy (LDHM) relies on interference between an unscattered reference wave and a weakly scattered object wave - an assumption that rapidly fails in turbid samples under multiple scattering. To overcome this…

In this paper, we describe the modification of Nanoscale Impedance Microscopy (NIM), namely, a combination of contact-mode atomic force microscopy with local impedance measurements. The postulated approach is based on the application of…

The major resolution-limiting factor in cryoelectron microscopy of unstained biological specimens is radiation damage by the very electrons that are used to probe the specimen structure. To address this problem, an electron microscopy…

Quantum Physics · Physics 2015-06-18 Hiroshi Okamoto

Intermodulation atomic force microscopy (IMAFM) is a dynamic mode of atomic force microscopy (AFM) with two-tone excitation. The oscillating AFM cantilever in close proximity to a surface experiences the nonlinear tip-sample force which…

Mesoscale and Nanoscale Physics · Physics 2013-02-08 Daniel Platz , Erik A. Tholen , Carsten Hutter , Arndt C. von Bieren , David B. Haviland

We study nonequilibrium properties of an electronic Mach-Zehnder interferometer built from integer quantum Hall edge states at filling fraction $\nu{=}1$. For a model in which electrons interact only when they are inside the interferometer,…

Mesoscale and Nanoscale Physics · Physics 2009-10-27 D. L. Kovrizhin , J. T. Chalker

Light sheet fluorescence microscopy (LSFM) has transformed the way we visualize biological tissues in three dimensions, offering high-resolution imaging while minimizing photo-induced damage to the samples. Recent breakthroughs in…

Optics · Physics 2025-05-27 Alireza Tabatabaei Mashayekh , Jeremy Witzens

Interferometric scattering microscopy has been a very promising technology for highly sensitive label-free imaging of a broad spectrum of biological nanoparticles from proteins to viruses in a high-throughput manner. Although it can reveal…

Optics · Physics 2021-08-11 Celalettin Yurdakul , Haonan Zong , Yeran Bai , Ji-Xin Cheng , M. Selim Unlu