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Label-free imaging approaches seek to simplify and augment histopathologic assessment by replacing the current practice of staining by dyes to visualize tissue morphology with quantitative optical measurements. Quantitative phase imaging…

Biological soft tissues encountered in clinical and pre-clinical imaging mainly consist of light element atoms, and their composition is nearly uniform with little density variation. Thus, x-ray attenuation imaging suffers from low image…

Medical Physics · Physics 2011-06-28 Wenxiang Cong , Atsushi Momose , Ge Wang

Histological images are obtained by transmitting light through a tissue specimen that has been stained in order to produce contrast. This process results in 2D images of the specimen that has a three-dimensional structure. In this paper, we…

Computer Vision and Pattern Recognition · Computer Science 2018-01-11 Maxime W. Lafarge , Josien P. W. Pluim , Koen A. J. Eppenhof , Pim Moeskops , Mitko Veta

We introduce a novel, training-free system for reconstructing, understanding, and rendering 3D indoor scenes from a sparse set of unposed RGB images. Unlike traditional radiance field approaches that require dense views and per-scene…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Jiatong Xia , Lingqiao Liu

This work introduces Structured 3D-SVD as a practical framework for the reconstruction, compression, and analysis of biological volumetric data. Inspired by the logic of matrix singular value decomposition (SVD), the proposed approach…

Image and Video Processing · Electrical Eng. & Systems 2026-04-21 Mario Aragonés Lozano , Oscar Romero , Antonio León

A white light system based on a 65 cm x 35 cm diffractive screen is demonstrated to be capable of displaying three-dimensional figures with continuous horizontal parallax. Three computer-controlled mirrors and a diffractive-refractive…

Optics · Physics 2015-05-27 Jose J. Lunazzi , M. Diamand

We present an alternative numerical reconstruction algorithm for direct tomographic reconstruction of a sample refractive indices from the measured intensities of its far-field coherent diffraction patterns. We formulate the well-known…

Computational Physics · Physics 2019-02-06 T. Ramos , Bastian E. Grønager , Martin Skovgaard Andersen , J. W. Andreasen

Three-dimensional (3D) refractive index (RI) tomography offers label-free, quantitative volumetric imaging but faces limitations due to optical aberrations, limited resolution, and the computational complexity inherent to existing…

A solution to the inversion problem of scattering would offer aberration-free diffraction-limited 3D images without the resolution and depth-of-field limitations of lens-based tomographic systems. Powerful algorithms are increasingly being…

Many biological and soft matter processes occur at high speeds in complex 3D environments, and developing imaging techniques capable of elucidating their dynamics is an outstanding experimental challenge. Here, we introduce Fourier…

The authors introduce a general mechanism, based on electrostatic and magnetostatic considerations, for designing three-dimensional isotopic metamaterials that possess an enhanced refractive index over an extremely large frequency range.…

Optics · Physics 2009-11-13 Jonghwa Shin , Jung-Tsung Shen , Shanhui Fan

Ascertaining the collective viability of cells in different cell culture conditions has typically relied on averaging colorimetric indicators and is often reported out in simple binary readouts. Recent research has combined viability…

Quantitative Methods · Quantitative Biology 2024-04-03 Kylie J. Trettner , Jeremy Hsieh , Weikun Xiao , Jerry S. H. Lee , Andrea M. Armani

Optical diffraction tomography (ODT) has emerged as an important label-free tool in biomedicine to measure the three-dimensional (3D) structure of a biological sample. In this paper, we describe ODT using second-harmonic generation (SHG)…

Optics · Physics 2024-05-21 Amirhossein Saba , Carlo Gigli , Ye Pu , Demetri Psaltis

Microscopy enables direct observation of cellular morphology in 3D, with transmitted-light methods offering low-cost, minimally invasive imaging and fluorescence microscopy providing specificity and contrast. Virtual staining combines these…

CNN-based volumetric methods that label individual voxels now dominate the field of biomedical segmentation. However, 3D surface representations are often required for proper analysis. They can be obtained by post-processing the labeled…

Computer Vision and Pattern Recognition · Computer Science 2020-04-02 Udaranga Wickramasinghe , Edoardo Remelli , Graham Knott , Pascal Fua

This paper proposes the use of an end-to-end Convolutional Neural Network for direct reconstruction of the 3D geometry of humans via volumetric regression. The proposed method does not require the fitting of a shape model and can be trained…

Computer Vision and Pattern Recognition · Computer Science 2018-09-12 Aaron S. Jackson , Chris Manafas , Georgios Tzimiropoulos

Direct imaging methods recover the presence, position, and shape of the unknown obstacles in time-harmonic inverse scattering without a priori knowledge of either the physical properties or the number of disconnected components of the…

Analysis of PDEs · Mathematics 2023-11-29 General Ozochiawaeze

Full-field optical coherence tomography (FF-OCT) offers label-free, high-resolution imaging of biological samples but remains limited by slow acquisition due to piezoelectric mirror modulation. We present a continuous-scanning FF-OCT method…

Optics · Physics 2025-09-11 Charlie Kersuzan , Anirban Jana , Amaury Badon

We present an approach for aggregating a sparse set of views of an object in order to compute a semi-implicit 3D representation in the form of a volumetric feature grid. Key to our approach is an object-centric canonical 3D coordinate…

Computer Vision and Pattern Recognition · Computer Science 2020-07-22 Shubham Tulsiani , Or Litany , Charles R. Qi , He Wang , Leonidas J. Guibas

Three-dimensional elements, with refractive index distribution structured at sub-wavelength scale, provide an expansive optical design space that can be harnessed for demonstrating multi-functional free-space optical devices. Here we…

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