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Refractive index is a fundamental optical property of powder and a key input to the measurement of the size distribution using light scattering and the measurement of the absorption and scattering coefficients using diffuse reflectance…

Optics · Physics 2024-03-05 Cory Juntunen , Adam J. Rish , Carl Anderson , Yongjin Sung

In this work, a refractive index (RI) sensor with an effective integration of colorimetric detection and optical sensing capabilities has been developed. Colorimetric detection relies on the sensitivity of the structural color of photonic…

Optics · Physics 2021-07-09 Cheng Fang , Qingqing Shang , Fen Tang , Songlin Yang , Ran Ye

White light spectral interferometry is applied to measure the refractive index in absorbing liquids in the spectral range from 400 to 1000 nm. We analyze the influence of absorption on the visibility of interferometric fringes and,…

We developed a microscopy technique that can measure the local refractive index without sampling the optical phase delay of the electromagnetic radiation. To do this, we designed and experimentally demonstrated a setup with two co-localized…

Optics · Physics 2019-03-27 Antonio Fiore , Carlo Bevilacqua , Giuliano Scarcelli

Optical microscopy has been employed to derive salient characteristics of an object in various fields, including cell biology, flow cytometry, biopsy, and neuroscience. In particular, measuring the phase of light scattered from an object…

Optics · Physics 2025-03-18 Jeonghun Oh , Herve Hugonnet , Weisun Park , YongKeun Park

The refractive index (RI) of cells and tissues is crucial in pathophysiology as a noninvasive and quantitative imaging contrast. Although its measurements have been demonstrated using three-dimensional quantitative phase imaging methods,…

Measuring the average refractive index (RI) of spherical objects, such as suspended cells, in quantitative phase imaging (QPI) requires a decoupling of RI and size from the QPI data. This has been commonly achieved by determining the…

Quantitative Methods · Quantitative Biology 2018-04-27 Paul Müller , Mirjam Schürmann , Salvatore Girardo , Gheorghe Cojoc , Jochen Guck

Total internal reflection fluorescence (TIRF) microscopy and its variants are key technologies for visualizing the dynamics of single molecules or organelles in live cells. Yet, truely quantitative TIRF remains problematic. One unknown…

Biological Physics · Physics 2017-06-07 Maia Brunstein , Lopamudra Roy , Martin Oheim

Knowledge of optical properties, such as the refractive index (RI), of biological tissues is important in optical imaging, as they influence the distribution and propagation of light in tissue. To accurately study the response of cancerous…

Biological Physics · Physics 2019-04-10 Neelam Hari , Priyanka Patel , Jacqueline Ross , Kevin Hicks , Frédérique Vanholsbeeck

Phase-sensitive integrated photonic devices are highly susceptible to minor manufacturing deviations, resulting in significant performance inconsistencies. This variability has limited the scalability and widespread adoption of these…

We demonstrate ultrasound detection with 500-$\mu\mathrm{{m}}$-diameter photonic-crystal slab (PCS) sensors fabricated from CMOS-compatible technology. An ultrasound signal impinging a PCS sensor causes a local modulation of the refractive…

Applied Physics · Physics 2019-06-11 Eric Y. Zhu , Cory Rewcastle , Raanan Gad , Li Qian , Ofer Levi

The real part of the refractive index (RI) of aqueous solutions of human hemoglobin is computed from their absorption spectra in the wavelength range $250\,{\rm nm} - 1100\,{\rm nm}$ using the Kramers-Kronig (KK) relations and the…

Biological Physics · Physics 2017-11-08 Jonas Gienger , Hermann Groß , Jörg Neukammer , Markus Bär

We present broadband cavity-enhanced complex refractive index spectroscopy (CE-CRIS), a technique for calibration-free determination of the complex refractive index of entire molecular bands via direct measurement of transmission modes of a…

A novel method is proposed to measure the refractive indices (RIs) of the materials of different transparent solid state media. To exploit the advantage of non-contact measurement laser beam interferometry is used as an effective technique…

Physics Education · Physics 2024-06-19 Arnab Pal , Kriti R. Sahu , Pradipta Panchadhyayee , Debapriyo Syam

Quantitative phase imaging (QPI) is important in many applications such as microscopy and crystallography. To quantitatively reveal phase information, people could either employ interference to map phase distribution into intensity fringes,…

Optics · Physics 2020-11-11 Xianye Li , Yafei sun , Yikang He , Xun Li , Baoqing Sun

Photopolymerization enables the production of micro-optical elements, such as diffractive optical elements or GRIN optics. This process utilizes targeted spatial modulation of the refractive index, which is achieved through additive…

Optics · Physics 2026-03-16 Andreas Heinrich , Manuel Rank

Integrated photonic chips have significant potential in telecommunications, classic computing, quantum systems, and topological photonics. Direct laser writing offers unique capability for creating three-dimensional photonic devices in an…

We present highly sensitive refractometers based on a long-period grating in a large mode area PCF. The maximum sensitivity is 1500 nm/RIU at a refractive index of 1.33, the highest reported for any fiber grating. The minimal detectable…

Optics · Physics 2009-11-13 Lars Rindorf , Ole Bang

Here, we present a novel microscopic technique for measuring wavelength-dependent three-dimensional (3-D) distributions of the refractive indices (RIs) of microscopic samples in the visible wavelengths. Employing 3-D quantitative phase…

Optics · Physics 2016-04-20 JaeHwang Jung , Kyoohyun Kim , Jonghee Yoon , YongKeun Park

Fluorescence microscopy is a powerful tool for imaging biological samples with molecular specificity. In contrast, phase microscopy provides label-free measurement of the sample's refractive index (RI), which is an intrinsic optical…

Optics · Physics 2022-01-26 Yi Xue , David Ren , Laura Waller
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