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We study the temporal and the synchronous behaviours in p53-Mdm2 regulatory network due to the interaction of its complex network components with the nitric oxide molecule. In single cell process, increase in nitric oxide concentration…

Molecular Networks · Quantitative Biology 2014-09-09 Gurumayum Reenaroy Devi , Md. Jahoor Alam , Ram Ramaswamy , R. K. Brojen Singh

The effects of intrinsic noise on stochastic delay systems is studied within an expansion in the inverse system size. We show that the stochastic nature of the underlying dynamics may induce oscillatory behaviour in parameter ranges where…

Molecular Networks · Quantitative Biology 2015-05-13 Tobias Galla

Spiking neural networks (SNNs) can be used for implementing cost-efficient artificial intelligence computing or mechanistic modelling of experimentally observed neural data. In the latter, fitting neural data with recurrent SNNs (RSNNs)…

Neurons and Cognition · Quantitative Biology 2026-05-26 Divyansh Sethi , Muhammad Faraz , KongFatt Wong-Lin

It is well known that, under suitable conditions, microRNAs are able to fine tune the relative concentration of their targets to any desired value. We show that this function is particularly effective when one of the targets is a…

Molecular Networks · Quantitative Biology 2015-06-16 Andrea Riba , Carla Bosia , Mariama El Baroudi , Laura Ollino , Michele Caselle

Biological systems use neural circuits to integrate input information and produce outputs. Synaptic convergence, where multiple neurons converge their inputs onto a single downstream neuron, is common in natural neural circuits. However,…

Mesoscale and Nanoscale Physics · Physics 2026-02-04 Wendy Otieno , Alex Gabbitas , Debi Pattnaik , Pavel Borisov , Sergey Savel'ev , Alexander G. Balanov

We analyze the emergence of synchronization in a population of moving integrate-and-fire oscillators. Oscillators, while moving on a plane, interact with their nearest neighbor upon firing time. We discover a non-monotonic dependence of the…

Adaptation and Self-Organizing Systems · Physics 2013-12-06 Luce Prignano , Oleguer Sagarra , Albert Díaz-Guilera

We revisit the dynamics of a gene repressed by its own protein in the case where the transcription rate does not adapt instantaneously to protein concentration but is a dynamical variable. We derive analytical criteria for the appearance of…

Quantitative Methods · Quantitative Biology 2009-02-19 Pierre-Emmanuel Morant , Quentin Thommen , François Lemaire , Constant Vandermoëre , Benjamin Parent , Marc Lefranc

The mechanism of phase synchronization between uncoupled limit-cycle oscillators induced by common external impulsive forcing is analyzed. By reducing the dynamics of the oscillator to a random phase map, it is shown that phase…

Adaptation and Self-Organizing Systems · Physics 2007-06-13 H. Nakao , K. Arai , K. Nagai , Y. Tsubo , Y. Kuramoto

The study on the collective dynamics of synchronization among genetic oscillators is essential for the understanding of the rhythmic phenomena of living organisms at both molecular and cellular levels. Genetic oscillators are biochemical…

Chaotic Dynamics · Physics 2007-05-23 Chunguang Li , Luonan Chen , Kazuyuki Aihara

The role of synchronous firing in sensory coding and cognition remains controversial. While studies, focusing on its mechanistic consequences in attentional tasks, suggest that synchronization dynamically boosts sensory processing, others…

Neurons and Cognition · Quantitative Biology 2019-05-07 Siavash Ghavami , Vahid Rahmati , Farshad Lahouti , Lars Schwabe

Non-conding RNAs play a key role in the post-transcriptional regulation of mRNA translation and turnover in eukaryotes. miRNAs, in particular, interact with their target RNAs through protein-mediated, sequence-specific binding, giving rise…

Molecular Networks · Quantitative Biology 2018-12-27 Araks Martirosyan , Marco Del Giudice , Chiara Enrico Bena , Andrea Pagnani , Carla Bosia , Andrea De Martino

In biochemical signaling, information is often encoded in oscillatory signals. However, the advantages of such a coding strategy over an amplitude encoding scheme of constant signals remain unclear. Here we study the dynamics of a simple…

Subcellular Processes · Quantitative Biology 2012-03-09 Filipe Tostevin , Wiet de Ronde , Pieter Rein ten Wolde

Synchronization plays a fundamental role in healthy cognitive and motor function. However, how synchronization depends on the interplay between local dynamics, coupling and topology and how prone to synchronization a network with given…

Neurons and Cognition · Quantitative Biology 2018-06-06 David Papo , Javier M. Buldú

Simple spike synchrony between Purkinje cells projecting to a common neuron in the deep cerebellar nucleus is emerging as an important factor in the encoding of output information from cerebellar cortex. Stochastic synchronization is a…

Neurons and Cognition · Quantitative Biology 2014-08-14 Sergio Verduzco-Flores

Cell movement and intercellular signaling occur simultaneously during the development of tissues, but little is known about how movement affects signaling. Previous theoretical studies have shown that faster moving cells favor…

Cell Behavior · Quantitative Biology 2012-05-09 Koichiro Uriu , Saul Ares , Andrew C. Oates , Luis G. Morelli

The structure of many real-world systems is best captured by networks consisting of several interaction layers. Understanding how a multi-layered structure of connections affects the synchronization properties of dynamical systems evolving…

Physics and Society · Physics 2016-11-17 Charo I. del Genio , Jesús Gómez-Gardeñes , Ivan Bonamassa , Stefano Boccaletti

The global dynamics of gene regulatory networks are known to show robustness to perturbations in the form of intrinsic and extrinsic noise, as well as mutations of individual genes. One molecular mechanism underlying this robustness has…

Molecular Networks · Quantitative Biology 2015-06-15 Claus Kadelka , David Murrugarra , Reinhard Laubenbacher

Using a stochastic generalization of the Hodgkin–Huxley model, we consider the influence of intrinsic channel noise on the synchronization between the spiking activity of the excitable membrane and an externally applied periodic…

Biological Physics · Physics 2007-05-23 Gerhard Schmid , Igor Goychuk , Peter Hanggi

Gene Regulatory Networks(GRNs) with feedback are essential components of many cellular processes and may exhibit oscillatory behavior. Analyzing such systems becomes increasingly complex as the number of components increases. Since gene…

Molecular Networks · Quantitative Biology 2026-04-22 Manuel Eduardo Hernández-García , Jorge Velázquez-Castro

In this Letter we identify the general rules that determine the synchronization properties of interconnected networks. We study analytically, numerically and experimentally how the degree of the nodes through which two networks are…

Physics and Society · Physics 2015-06-19 J. Aguirre , R. Sevilla-Escoboza , R. Gutiérrez , D. Papo , J. M. Buldú
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