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Noise in gene expression, either due to inherent stochasticity or to varying inter- and intracellular environment, can generate significant cell-to-cell variability of protein levels in clonal populations. We present a theoretical…

Other Quantitative Biology · Quantitative Biology 2010-04-08 Julia Rausenberger , Christian Fleck , Jens Timmer , Markus Kollmann

We aim to increase the ability of a of coupled phase oscillators to maintain the synchronization when the system is affected by stochastic disturbances. We model the disturbances by Gaussian noise and use the mean first hitting time when…

Adaptation and Self-Organizing Systems · Physics 2023-04-26 Xian Wu , Kaihua Xi , Aijie Cheng , Hai Xiang Lin , Jan H. van Schuppen

According to the `ceRNA hypothesis', microRNAs (miRNAs) may act as mediators of an effective positive interaction between long coding or non-coding RNA molecules, carrying significant potential implications for a variety of biological…

Molecular Networks · Quantitative Biology 2016-01-28 Araks Martirosyan , Matteo Figliuzzi , Enzo Marinari , Andrea De Martino

Numerous biological and microscale systems exhibit synchronization in noisy environments. The theory of such noisy oscillators and their synchronization has been developed and experimentally demonstrated, but inferring the noise intensity…

Adaptation and Self-Organizing Systems · Physics 2025-01-09 Hisa-Aki Tanaka , Somei Suga , Akira Keida , Hiroya Nakao , Yutaka Jitsumatsu , István Z. Kiss

We study the noise effects in a driven system of globally coupled oscillators, with particular attention to the interplay between driving and noise. The self-consistency equation for the order parameter, which measures the collective…

Statistical Mechanics · Physics 2009-10-31 H. Hong , M. Y. Choi , K. Park , B. -G. Yoon , K. -S. Soh

A universal mechanism underlying generalized synchronization conditions in unidirectionally coupled stochastic oscillators is considered. The consideration is carried out in the framework of a modified system with additional dissipation.…

Chaotic Dynamics · Physics 2009-11-11 A. A. Koronovskii , O. I. Moskalenko , A. E. Hramov

During cell division paired (sister) chromosomes are observed to perform approximate saw-tooth oscillations across the cell mid-plane. Experimental data suggests that these oscillations are regulated through intersister tension. We propose…

Biological Physics · Physics 2022-07-04 Nigel J. Burroughs , Andrew D. McAinsh

Brain rhythms contribute to every aspect of brain function. Here, we study critical and resonance phenomena that precede the emergence of brain rhythms. Using an analytical approach and simulations of a cortical circuit model of neural…

Disordered Systems and Neural Networks · Physics 2015-06-12 A. V. Goltsev , M. A. Lopes , K. -E. Lee , J. F. F. Mendes

Motivated by the aim to find new medical strategies to suppress undesirable neural synchronization we study the control of oscillations in a system of inhibitory coupled noisy oscillators. Using dynamical properties of inhibition, we find…

Disordered Systems and Neural Networks · Physics 2009-05-27 C. J. Tessone , E. Ullner , A. A. Zaikin , J. Kurths , R. Toral

Synchronization is one of the paradigmatic phenomena in the study of complex systems. It has been explored theoretically and experimentally mostly to understand natural phenomena, but also in view of technological applications. Although…

This work is devoted to the problem of synchronization of two Morris-Lecar neuron models. The Morris-Lecar model is a second-order system of differential equations, which describes an uneasy relationship between the membrane potential and…

Optimization and Control · Mathematics 2023-11-14 A. V. Rybalko , D. M. Semenov , A. L. Fradkov

The regulating mechanism of miRNA on p53 dynamics in p53-MDM2-miRNA model network incorporating reactive oxygen species (ROS) is studied. The study shows that miRNA drives p53 dynamics at various states, namely, stabilized states and…

Molecular Networks · Quantitative Biology 2014-09-09 Md. Jahoor Alam , Shazia Kunvar , R. K. Brojen Singh

We study some mechanisms responsible for synchronous oscillations and loss of synchrony at physiologically relevant frequencies (10-200 Hz) in a network of heterogeneous inhibitory neurons. We focus on the factors that determine the level…

Neurons and Cognition · Quantitative Biology 2007-05-23 J. A. White , C. C. Chow , J. Ritt , C. Soto-Trevino , N. Kopell

Random perturbations applied in tandem to an ensemble of oscillating objects can synchronize their motion. We study multiple copies of an arbitrary dynamical system in a stable limit cycle, described via a standard phase reduction picture.…

Statistical Mechanics · Physics 2024-02-23 Yunxiang Song , Thomas A. Witten

The synchronization stability of a complex network system of coupled phase oscillators is discussed. In case the network is affected by disturbances, a stochastic linearized system of the coupled phase oscillators may be used to determine…

Adaptation and Self-Organizing Systems · Physics 2023-03-31 Kaihua Xi , Zhen Wang , Aijie Cheng , Hai Xiang Lin , Jan H. van Schuppen , Chenghui Zhang

Cell phenotype dynamic homeostasis contrasts with the inherent randomness of intracellular reactions. Although feedback control of master regulatory genes (MRG) is a key strategy for maintaining gene network expression ranges limited,…

Molecular Networks · Quantitative Biology 2025-08-13 Guilherme Giovanini , Cyro von Zuben de Valega Negrão , Ammar Alsinai , Alexandre Ferreira Ramos

In this work, we investigate the synchronization in oscillators with conjugate coupling in which oscillators interact via dissimilar variables. The synchronous dynamics and its stability are investigated theoretically and numerically. We…

Chaotic Dynamics · Physics 2016-10-05 Wenchen Han , Mei Zhang , Junzhong Yang

The origin of stochastic fluctuations in gene expression has received considerable attention recently. Fluctuations in gene expression are particularly pronounced in cellular systems because of the small copy number of species undergoing…

Subcellular Processes · Quantitative Biology 2009-08-02 P. S. Gutierrez , D. Monteoliva , L. Diambra

Synchronization is an ubiquitous phenomenon in dynamical systems of networked oscillators. While it is often a goal to achieve, in some context one would like to decrease it, e.g., although synchronization is essential to the good…

Dynamical Systems · Mathematics 2025-04-07 Martin Moriamé , Timoteo Carletti

Two remote agents with synchronized clocks may use them to act in concert and communicate. This necessitates some means of creating and maintaining synchrony. One method, not requiring any direct interaction between the agents, is to expose…

Statistical Mechanics · Physics 2026-05-20 Benjamin Sorkin , Thomas A. Witten
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