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We analyze the dynamics of networks of spiking neural oscillators. First, we present an exact linear stability theory of the synchronous state for networks of arbitrary connectivity. For general neuron rise functions, stability is…

Neurons and Cognition · Quantitative Biology 2009-11-11 Marc Timme , Theo Geisel , Fred Wolf

Population-wide oscillations are ubiquitously observed in mesoscopic signals of cortical activity. In these network states a global oscillatory cycle modulates the propensity of neurons to fire. Synchronous activation of neurons has been…

Neurons and Cognition · Quantitative Biology 2017-07-04 Tobias Kühn , Moritz Helias

A simple stochastic model of a self regulating gene that displays bistable switching is analyzed. While on, a gene transcribes mRNA at a constant rate. Transcription factors can bind to the DNA and affect the gene's transcription rate.…

Statistical Mechanics · Physics 2016-03-08 Jay Newby

microRNAs (miRNAs) regulate gene expression at post-transcriptional level by repressing target RNA molecules. Competition to bind miRNAs tends in turn to correlate their targets, establishing effective RNA-RNA interactions that can…

Molecular Networks · Quantitative Biology 2020-07-01 Mattia Miotto , Enzo Marinari , Andrea De Martino

In a network of dynamical systems, concurrent synchronization is a regime where multiple groups of fully synchronized elements coexist. In the brain, concurrent synchronization may occur at several scales, with multiple ``rhythms''…

Neurons and Cognition · Quantitative Biology 2007-05-23 Quang-Cuong Pham , Jean-Jacques Slotine

Chemical reactions in cell are subject to intense stochastic fluctuations. An important question is how the fundamental physiological behavior of cell is kept stable against those noisy perturbations. In this paper a stochastic model of…

Molecular Networks · Quantitative Biology 2009-11-13 Yurie Okabe , Masaki Sasai

Cooperative effects of periodic force and noise in globally Cooperative effects of periodic force and noise in globally coupled systems are studied using a nonlinear diffusion equation for the number density. The amplitude of the order…

Chaotic Dynamics · Physics 2009-11-07 Hidetsugu Sakaguchi

Synchronization, the emergence of spontaneous order in coupled systems, is of fundamental importance in both physical and biological systems. We demonstrate the synchronization of two dissimilar silicon nitride micromechanical oscillators,…

Synthetic biology sets out to implement new functions in cells, and to develop a deeper understanding of biological design principles. In 2000, Elowitz and Leibler showed that by rational design of the reaction network, and using existing…

Biological Physics · Physics 2017-05-17 Joris Paijmans , David K Lubensky , Pieter Rein ten Wolde

In the past decades microRNAs (miRNA) have much attracted the attention of researchers at the interface between life and theoretical sciences for their involvement in post-transcriptional regulation and related diseases. Thanks to the…

Molecular Networks · Quantitative Biology 2020-02-11 Elsi Ferro , Chiara Enrico Bena , Silvia Grigolon , Carla Bosia

The phenomenon of self-induced stochastic resonance (SISR) requires a nontrivial scaling limit between the deterministic and the stochastic timescales of an excitable system, leading to the emergence of coherent oscillations which are…

Adaptation and Self-Organizing Systems · Physics 2021-12-07 Florian Bönsel , Patrick Krauss , Claus Metzner , Marius E. Yamakou

Synchronization is a universal phenomenon found in many non-equilibrium systems. Much recent interest in this area has overlapped with the study of complex networks, where a major focus is determining how a system's connectivity patterns…

Adaptation and Self-Organizing Systems · Physics 2015-08-19 Jason Hindes , Christopher R. Myers

We report experimental studies of synchronization phenomena in a pair of biological neurons that interact through naturally occurring, electrical coupling. When these neurons generate irregular bursts of spikes, the natural coupling…

We study systems of identical coupled oscillators introducing a distribution of delay times in the coupling. For arbitrary network topologies, we show that the frequency and stability of the fully synchronized states depend only on the mean…

Chaotic Dynamics · Physics 2016-07-04 Lucas Wetzel , Luis G. Morelli , Andrew C. Oates , Frank Julicher , Saul Ares

We investigate macroscopic behavior of a dynamical network consisting of a time-evolving wiring of interactions among a group of random walkers. We assume that each walker (agent) has an oscillator and show that depending upon the nature of…

Chaotic Dynamics · Physics 2017-07-06 Soumen Majhi , Dibakar Ghosh

Oscillators coupled in a network can synchronize with each other to yield a coherent population rhythm. If multiple such networks are coupled together, the question arises whether these rhythms will synchronize. We investigate the impact of…

Adaptation and Self-Organizing Systems · Physics 2016-12-22 John Hongyu Meng , Hermann Riecke

Synchronization is central to many complex systems in engineering physics (e.g., the power-grid, Josephson junction circuits, and electro-chemical oscillators) and biology (e.g., neuronal, circadian, and cardiac rhythms). Despite these…

Adaptation and Self-Organizing Systems · Physics 2017-01-13 Dane Taylor , Per Sebastian Skardal , Jie Sun

Understanding the origin of phase synchronization between quantum self-sustained oscillators has garnered significant interest in recent years. In this work, we study phase synchronization in three settings: between two continuous-variable…

Quantum Physics · Physics 2025-06-03 Mohit Kumar , Bijay Kumar Agarwalla

The dynamic behaviors of microRNA and mRNA under external stress are studied with biological experiments and mathematics models. In this study, we developed a mathematic model to describe the biological phenomenon and for the first time…

Molecular Networks · Quantitative Biology 2013-12-17 Bin Ao , Sheng Zhang , Caiyong Ye , Lei Chang , Guangming Zhou , Lei Yang

A biophysical model of arousal dynamics is used to study mechanisms of synchronisation and loss of synchrony among the three key oscillators controlling sleep-wake cycles: the circadian, homeostatic, and light oscillators. Synchronisation…

Biological Physics · Physics 2021-01-22 Dmitry E. Postnov , Ksenia O. Merkulova , Svetlana Postnova