Oscillations in the expression of a self-repressed gene induced by a slow transcriptional dynamics
Quantitative Methods
2009-02-19 v2 Molecular Networks
Abstract
We revisit the dynamics of a gene repressed by its own protein in the case where the transcription rate does not adapt instantaneously to protein concentration but is a dynamical variable. We derive analytical criteria for the appearance of sustained oscillations and find that they require degradation mechanisms much less nonlinear than for infinitely fast regulation. Deterministic predictions are also compared with stochastic simulations of this minimal genetic oscillator.
Keywords
Cite
@article{arxiv.0803.4415,
title = {Oscillations in the expression of a self-repressed gene induced by a slow transcriptional dynamics},
author = {Pierre-Emmanuel Morant and Quentin Thommen and François Lemaire and Constant Vandermoëre and Benjamin Parent and Marc Lefranc},
journal= {arXiv preprint arXiv:0803.4415},
year = {2009}
}