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Digital twins require high-quality data to achieve predictive capability, but time and resource limitations make efficient experiment design essential. Model-based design of experiments can address this challenge, especially when coupled…
In this paper we consider the problem of constructing $T$-optimal discriminating designs for Fourier regression models. We provide explicit solutions of the optimal design problem for discriminating between two Fourier regression models,…
In a physical design problem, the designer chooses values of some physical parameters, within limits, to optimize the resulting field. We focus on the specific case in which each physical design parameter is the ratio of two field…
We design optimal $2 \times N$ ($2 <N$) matrices, with unit columns, so that the maximum condition number of all the submatrices comprising 3 columns is minimized. The problem has two applications. When estimating a 2-dimensional signal by…
A number of problems in quantum state and system identification are addressed. Specifically, it is shown that the maximum likelihood estimation (MLE) approach, already known to apply to quantum state tomography, is also applicable to…
We develop a new method for equality constrained optimization problems based on a sequential cubic programming framework. Each iteration utilizes a step decomposition based on the Jacobian of the constraints into a normal and a tangential…
The subject of this work is multiple group random coefficients regression models with several treatments and one control group. Such models are often used for studies with cluster randomized trials. We investigate A-, D- and E-optimal…
Planes are generally used in 3D reconstruction for depth sensors, such as RGB-D cameras and LiDARs. This paper focuses on the problem of estimating the optimal planes and sensor poses to minimize the point-to-plane distance. The resulting…
We develop a unified framework for identifying bounds to maximum resonant nonlinear optical susceptibilities, and for "inverse designing" quantum-well structures that can approach such bounds. In special cases (e.g. second-harmonic…
In electromagnetism, the model of Maxwell's equations yields accurate and trustworthy predictions. Numerical solvers can reach electromagnetic solutions far beyond the set of analytical closed-form solutions; this is crucial in…
We clarify the mathematical structure underlying unitary $t$-designs. These are sets of unitary matrices, evenly distributed in the sense that the average of any $t$-th order polynomial over the design equals the average over the entire…
For a Hamiltonian $K \in C^2(\mathbb{R}^{N \times n})$ and a map $u:\Omega \subseteq \mathbb{R}^n \longrightarrow \mathbb{R}^N$, we consider the supremal functional \[ \label{1} \tag{1} E_\infty (u,\Omega) \ :=\…
We consider optimal design of PDE-based Bayesian linear inverse problems with infinite-dimensional parameters. We focus on the A-optimal design criterion, defined as the average posterior variance and quantified by the trace of the…
We improve the existing results of optimal partial profile paired choice designs and provide new designs for situations where the choice set sizes are greater than two. The optimal designs are obtained under the main effects models and the…
We consider the problem of constructing optimal designs for population pharmacokinetics which use random effect models. It is common practice in the design of experiments in such studies to assume uncorrelated errors for each subject. In…
We derive optimal statistical and computational complexity bounds for exp-concave stochastic minimization in terms of the effective dimension. For common eigendecay patterns of the population covariance matrix, this quantity is…
Sequential Bayesian optimal experimental design (SBOED) for PDE-governed inverse problems is computationally challenging, especially for infinite-dimensional random field parameters. High-fidelity approaches require repeated forward and…
We consider linear model reduction in both the control and state variables for unconstrained linear-quadratic optimal control problems subject to time-varying parabolic PDEs. The first-order optimality condition for a state-space reduced…
Let $\D_{v,b,k}$ denote the family of all connected block designs with $v$ treatments and $b$ blocks of size $k$. Let $d\in\D_{v,b,k}$. The replication of a treatment is the number of times it appears in the blocks of $d$. The matrix…
A remarkable connection between optimal design and Monge transport was initiated in the years 1997 in the context of the minimal elastic compliance problem and where the euclidean metric cost was naturally involved. In this paper we present…