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Nonlinear regression models addressing both efficacy and toxicity outcomes are increasingly used in dose-finding trials, such as in pharmaceutical drug development. However, research on related experimental design problems for corresponding…

Methodology · Statistics 2016-01-06 Holger Dette , Katrin Kettelhake , Kirsten Schorning , Weng Kee Wong , Frank Bretz

We consider adaptive finite element methods for second-order elliptic PDEs, where the arising discrete systems are not solved exactly. For contractive iterative solvers, we formulate an adaptive algorithm which monitors and steers the…

Numerical Analysis · Mathematics 2021-07-14 Gregor Gantner , Alexander Haberl , Dirk Praetorius , Stefan Schimanko

The aim of this work is to study, from an intrinsic and geometric point of view, second-order constrained variational problems on Lie algebroids, that is, optimization problems defined by a cost functional which depends on higher-order…

Mathematical Physics · Physics 2017-01-18 Leonardo Colombo

This paper introduces a nonconforming virtual element method for general second-order elliptic problems with variable coefficients on domains with curved boundaries and curved internal interfaces. We prove arbitrary order optimal…

Numerical Analysis · Mathematics 2024-10-25 Yi Liu , Alessandro Russo

We consider the problem of designing optimal $M \times N$ ($M \leq N$) sensing matrices which minimize the maximum condition number of all the submatrices of $K$ columns. Such matrices minimize the worst-case estimation errors when only $K$…

Information Theory · Computer Science 2012-06-04 Hema Kumari Achanta , Soura Dasgupta , Weiyu Xu

The interference model has been widely used and studied in block experiments where the treatment for a particular plot has effects on its neighbor plots. In this paper, we study optimal circular designs for the proportional interference…

Statistics Theory · Mathematics 2015-07-31 Kang Li , Wei Zheng , Mingyao Ai

We consider optimal experimental design (OED) for nonlinear inverse problems within the Bayesian framework. Optimizing the data acquisition process for large-scale nonlinear Bayesian inverse problems is a computationally challenging task…

Numerical Analysis · Mathematics 2024-05-14 Karina Koval , Ruanui Nicholson

We consider the linear regression model with observation error in the design. In this setting, we allow the number of covariates to be much larger than the sample size. Several new estimation methods have been recently introduced for this…

Statistics Theory · Mathematics 2016-07-05 Alexandre Belloni , Mathieu Rosenbaum , Alexandre Tsybakov

Consider the optimal subspace expansion problem for the matrix eigenvalue problem $Ax=\lambda x$: Which vector $w$ in the current subspace $\mathcal{V}$, after multiplied by $A$, provides an optimal subspace expansion for approximating a…

Numerical Analysis · Mathematics 2023-09-19 Zhongxiao Jia

Optimal experimental design is an essential subfield of statistics that maximizes the chances of experimental success. The D- and A-optimal design is a very challenging problem in the field of optimal design, namely minimizing the…

Neural and Evolutionary Computing · Computer Science 2022-08-25 Lyuyang Tong

Second-order optimization methods, such as cubic regularized Newton methods, are known for their rapid convergence rates; nevertheless, they become impractical in high-dimensional problems due to their substantial memory requirements and…

Optimization and Control · Mathematics 2024-01-09 Ruichen Jiang , Parameswaran Raman , Shoham Sabach , Aryan Mokhtari , Mingyi Hong , Volkan Cevher

The explicit constraint force method (ECFM) was recently introduced as a novel formulation of the physics-informed solution reconstruction problem, and was subsequently extended to inverse problems. In both solution reconstruction and…

Numerical Analysis · Mathematics 2026-01-09 Conor Rowan

In this work we investigate the min-max-min robust optimization problem and the k-adaptability robust optimization problem for binary problems with uncertain costs. The idea of the first approach is to calculate a set of k feasible…

Optimization and Control · Mathematics 2023-08-16 Jannis Kurtz

Optimal recovery is a mathematical framework for learning functions from observational data by adopting a worst-case perspective tied to model assumptions on the functions to be learned. Working in a finite-dimensional Hilbert space, we…

Optimization and Control · Mathematics 2023-10-17 Simon Foucart , Chunyang Liao

Given an experimental set-up and a fixed number of measurements, how should one take data in order to optimally reconstruct the state of a quantum system? The problem of optimal experiment design (OED) for quantum state tomography was first…

Quantum Physics · Physics 2011-11-22 J. Nunn , B. J. Smith , G. Puentes , J. S. Lundeen , I. A. Walmsley

Systems with both quantitative and qualitative responses are widely encountered in many applications. Design of experiment methods are needed when experiments are conducted to study such systems. Classic experimental design methods are…

Methodology · Statistics 2023-04-24 Lulu Kang , Xinwei Deng , Ran Jin

We consider the problem of finding a best uniform approximation to the standard monomial on the unit ball in $\bbC^2$ by polynomials of lower degree with complex coefficients. We reduce the problem to a one-dimensional weighted minimization…

Classical Analysis and ODEs · Mathematics 2010-02-11 I. Moale , P. Yuditskii

In a recent paper, Bubeck, Lee, and Singh introduced a new first order method for minimizing smooth strongly convex functions. Their geometric descent algorithm, largely inspired by the ellipsoid method, enjoys the optimal linear rate of…

Optimization and Control · Mathematics 2017-03-02 Dmitriy Drusvyatskiy , Maryam Fazel , Scott Roy

We revisit a classical airfoil design problem: the search for shapes that maximize aerodynamic performance metrics, targeting the underexplored intermediate Reynolds-number regime between 1 and 3000, relevant to small animals and miniature…

Fluid Dynamics · Physics 2026-05-20 Gleb Zhdanko , Dmitry Kolomenskiy

In both real and complex cases, we establish the connection of the problem about $2$-dimensional linear subspaces the most deviating from the coordinate ones with one simply formulated optimization problem for isoperimetric polygons in…

Numerical Analysis · Mathematics 2024-08-30 Yuri Nesterenko