Mutation timing in a spatial model of evolution
Abstract
Motivated by models of cancer formation in which cells need to acquire mutations to become cancerous, we consider a spatial population model in which the population is represented by the -dimensional torus of side length . Initially, no sites have mutations, but sites with mutations acquire an th mutation at rate per unit area. Mutations spread to neighboring sites at rate , so that time units after a mutation, the region of individuals that have acquired the mutation will be a ball of radius . We calculate, for some ranges of the parameter values, the asymptotic distribution of the time required for some individual to acquire mutations. Our results, which build on previous work of Durrett, Foo, and Leder, are essentially complete when and when for all .
Keywords
Cite
@article{arxiv.2001.01175,
title = {Mutation timing in a spatial model of evolution},
author = {Jasmine Foo and Kevin Leder and Jason Schweinsberg},
journal= {arXiv preprint arXiv:2001.01175},
year = {2020}
}