English

Mutation timing in a spatial model of evolution

Probability 2020-01-07 v1 Populations and Evolution

Abstract

Motivated by models of cancer formation in which cells need to acquire kk mutations to become cancerous, we consider a spatial population model in which the population is represented by the dd-dimensional torus of side length LL. Initially, no sites have mutations, but sites with i1i-1 mutations acquire an iith mutation at rate μi\mu_i per unit area. Mutations spread to neighboring sites at rate α\alpha, so that tt time units after a mutation, the region of individuals that have acquired the mutation will be a ball of radius αt\alpha t. We calculate, for some ranges of the parameter values, the asymptotic distribution of the time required for some individual to acquire kk mutations. Our results, which build on previous work of Durrett, Foo, and Leder, are essentially complete when k=2k = 2 and when μi=μ\mu_i = \mu for all ii.

Keywords

Cite

@article{arxiv.2001.01175,
  title  = {Mutation timing in a spatial model of evolution},
  author = {Jasmine Foo and Kevin Leder and Jason Schweinsberg},
  journal= {arXiv preprint arXiv:2001.01175},
  year   = {2020}
}
R2 v1 2026-06-23T13:03:02.338Z