The waiting time for a second mutation: an alternative to the Moran model
Probability
2014-03-05 v1 Populations and Evolution
Abstract
The appearance of cancer in a tissue is thought to be the result of two or more successive mutations. We propose a stochastic model that allows for an exact computation of the distribution of the waiting time for a second mutation. This models the time of appearance of the first cancerous cell in a tissue. Our model is an alternative to the Moran model with mutations.
Keywords
Cite
@article{arxiv.1306.6919,
title = {The waiting time for a second mutation: an alternative to the Moran model},
author = {Rinaldo B. Schinazi},
journal= {arXiv preprint arXiv:1306.6919},
year = {2014}
}