A waiting time problem arising from the study of multi-stage carcinogenesis
Probability
2010-05-20 v3 Tissues and Organs
Abstract
We consider the population genetics problem: how long does it take before some member of the population has specified mutations? The case is relevant to onset of cancer due to the inactivation of both copies of a tumor suppressor gene. Models for larger are needed for colon cancer and other diseases where a sequence of mutations leads to cells with uncontrolled growth.
Cite
@article{arxiv.0707.2057,
title = {A waiting time problem arising from the study of multi-stage carcinogenesis},
author = {Rick Durrett and Deena Schmidt and Jason Schweinsberg},
journal= {arXiv preprint arXiv:0707.2057},
year = {2010}
}
Comments
Published in at http://dx.doi.org/10.1214/08-AAP559 the Annals of Applied Probability (http://www.imstat.org/aap/) by the Institute of Mathematical Statistics (http://www.imstat.org)