Population genetics of neutral mutations in exponentially growing cancer cell populations
Populations and Evolution
2013-02-13 v1 Probability
Abstract
In order to analyze data from cancer genome sequencing projects, we need to be able to distinguish causative, or "driver," mutations from "passenger" mutations that have no selective effect. Toward this end, we prove results concerning the frequency of neutural mutations in exponentially growing multitype branching processes that have been widely used in cancer modeling. Our results yield a simple new population genetics result for the site frequency spectrum of a sample from an exponentially growing population.
Keywords
Cite
@article{arxiv.1302.2742,
title = {Population genetics of neutral mutations in exponentially growing cancer cell populations},
author = {Rick Durrett},
journal= {arXiv preprint arXiv:1302.2742},
year = {2013}
}
Comments
Published in at http://dx.doi.org/10.1214/11-AAP824 the Annals of Applied Probability (http://www.imstat.org/aap/) by the Institute of Mathematical Statistics (http://www.imstat.org)