Spatial Moran models I. Stochastic tunneling in the neutral case
Probability
2015-01-20 v1
Abstract
We consider a multistage cancer model in which cells are arranged in a -dimensional integer lattice. Starting with all wild-type cells, we prove results about the distribution of the first time when two neutral mutations have accumulated in some cell in dimensions , extending work done by Komarova [Genetics 166 (2004) 1571-1579] for .
Keywords
Cite
@article{arxiv.1501.04443,
title = {Spatial Moran models I. Stochastic tunneling in the neutral case},
author = {Richard Durrett and Stephen Moseley},
journal= {arXiv preprint arXiv:1501.04443},
year = {2015}
}
Comments
Published in at http://dx.doi.org/10.1214/13-AAP989 the Annals of Applied Probability (http://www.imstat.org/aap/) by the Institute of Mathematical Statistics (http://www.imstat.org)