相关论文: PCA and K-Means decipher genome

Principal Component Analysis (PCA) is a fundamental data preprocessing tool in the world of machine learning. While PCA is often thought of as a dimensionality reduction method, the purpose of PCA is actually two-fold: dimension reduction…

Bi-clustering is a useful approach in analyzing biological data when observations come from heterogeneous groups and have a large number of features. We outline a general Bayesian approach in tackling bi-clustering problems in moderate to…

In this paper, we present a new approach for decomposing scan paths and its utility for generating new scan paths. For this purpose, we use the K-Means clustering procedure to the raw gaze data and subsequently iteratively to find more…

Clustering analysis plays an important role in scientific research and commercial application. K-means algorithm is a widely used partition method in clustering. However, it is known that the K-means algorithm may get stuck at suboptimal…

We describe a robust, fast, and memory-efficient procedure that can cluster millions of structures derived from molecular dynamics simulations. The essence of the method is based on a peak-picking algorithm applied to three- and…

Rearrangements of bacterial chromosomes can be studied mathematically at several levels, most prominently at a local, or sequence level, as well as at a topological level. The biological changes involved locally are inversions, deletions,…

Microarrays are made it possible to simultaneously monitor the expression profiles of thousands of genes under various experimental conditions. Identification of co-expressed genes and coherent patterns is the central goal in microarray or…

Unsupervised clustering algorithms for vectors has been widely used in the area of machine learning. Many applications, including the biological data we studied in this paper, contain some boundary datapoints which show combination…

For open vocabulary recognition of ingredients in food images, segmenting the ingredients is a crucial step. This paper proposes a novel approach that explores PCA-based feature representations of image pixels using a convolutional neural…

With increasing urbanization, transportation plays an increasingly critical role in city development. The number of studies on modeling, optimization, simulation, and data analysis of transportation systems is on the rise. Many of these…

Principal components analysis (PCA) is a widely used dimension reduction technique with an extensive range of applications. In this paper, an online distributed algorithm is proposed for recovering the principal eigenspaces. We further…

Principal Component Analysis (PCA) is a well-known multivariate technique used to decorrelate a set of vectors. PCA has been extensively applied in the past to the classification of stellar and galaxy spectra. Here we apply PCA to the…

We propose kernel PCA as a method for analyzing the dependence structure of multivariate extremes and demonstrate that it can be a powerful tool for clustering and dimension reduction. Our work provides some theoretical insight into the…

Detecting variation in the evolutionary process along chromosomes is increasingly important as whole-genome data becomes more widely available. For example, factors such as incomplete lineage sorting, horizontal gene transfer, and…

Bioinformatics, which is now a well known field of study, originated in the context of biological sequence analysis. Recently graphical representation takes place for the research on DNA sequence. Research in biological sequence is mainly…

In several recent papers new gene-detection algorithms were proposed for detecting protein-coding regions without requiring learning dataset of already known genes. The fact that unsupervised gene-detection is possible closely connected to…

Computational methods for discovering patterns of local correlations in sequences are important in computational biology. Here we show how to determine the optimal partitioning of aligned sequences into non-overlapping segments such that…

Cognitive diagnosis models (CDMs) are a popular tool for assessing students' mastery of sets of skills. Given a set of $K$ skills tested on an assessment, students are classified into one of $2^K$ latent skill set profiles that represent…

The $k$-means is one of the most important unsupervised learning techniques in statistics and computer science. The goal is to partition a data set into many clusters, such that observations within clusters are the most homogeneous and…

In this paper, we propose and study a Nystr\"om based approach to efficient large scale kernel principal component analysis (PCA). The latter is a natural nonlinear extension of classical PCA based on considering a nonlinear feature map or…