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相关论文: Fast DNA translocation through a solid-state nanop…

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We measure the rheology of transient hydrogels comprised of a single type of DNA nanostar that makes both strong and weak bonds. These gels exhibit power-law frequency-dependence of their storage and loss moduli, with scaling exponents that…

软凝聚态物质 · 物理学 2023-08-29 Nathaniel Conrad , Omar A. Saleh , Deborah K. Fygenson

DNA nanotechnology uses predictable interactions of nucleic acids to precisely engineer complex nanostructures. Characterizing these self-assembled structures at the single-structure level is crucial for validating their design and…

生物物理 · 物理学 2025-10-21 Wangwei Dong , Zezhou Liu , Ruiyao Liu , Deborah Kuchnir Fygenson , Walter Reisner

Translocation of a single stranded DNA through genetically engineered $\alpha$-hemolysin channels with positively charged walls is studied. It is predicted that transport properties of such channels are dramatically different from neutral…

亚细胞过程 · 定量生物学 2008-09-10 Tao Hu , B. I. Shklovskii

Recent work has shown that the resistive force arising from viscous effects within the pore region could explain [Ghosal, S. Phys. Rev. E. vol. 71, 051904 (2006) and Phys. Rev. Lett. vol. 98, 238104 (2007)] observed translocation times in…

生物物理 · 物理学 2012-03-12 Sandip Ghosal

We demonstrate simultaneous measurements of DNA translocation into glass nanopores using ionic current detection and fluorescent imaging. We verify the correspondence between the passage of a single DNA molecule through the nanopore and the…

We report an accurate method to determine DNA barcodes from the dwell time measurement of protein tags (barcodes) along the DNA backbone using Brownian dynamics simulation of a model DNA and use a recursive theoretical scheme which improves…

软凝聚态物质 · 物理学 2021-02-09 Swarnadeep Seth , Aniket Bhattacharya

Solid-state nanopore DNA sequencers present mechanical and chemical stability, reusability, and large-scale integrability. However, their development is hindered by the absence of a protein-free mechanism for controlling DNA translocation,…

生物物理 · 物理学 2026-03-17 Tomoki Ohkubo

We investigate the translocation of a stiff polymer consisting of M monomers through a nanopore in a membrane, in the presence of binding particles (chaperones) that bind onto the polymer, and partially prevent backsliding of the polymer…

生物大分子 · 定量生物学 2015-06-26 T. Ambjoernsson , M. A. Lomholt , R. Metzler

The complex mechanisms governing charge migration in DNA oligomers reflect the rich structural and electronic properties of the molecule of life. Controlling the mechanical stability of DNA nanowires in charge transport experiments is a…

介观与纳米尺度物理 · 物理学 2015-05-13 Bo Song , Marcus Elstner , Gianaurelio Cuniberti

Molecular dynamics simulations are used to study the equilibrium distribution of monovalent ions in a nanopore connecting two water reservoirs separated by a membrane, both for the empty pore and that with a single stranded DNA molecule…

软凝聚态物质 · 物理学 2009-11-10 Yitzhak Rabin , Motohiko Tanaka

We consider elongated cylindrical particles, modeling e.g. DNA fragments or nano-rods, while translocating under the action of an externally applied voltage through a solid state nanopore. Particular emphasis is put on the concomitant…

软凝聚态物质 · 物理学 2013-07-15 Sebastian Getfert , Thomas Töws , Peter Reimann

Numerical results on the translocation of long biopolymers through mid-sized and wide pores are presented. The simulations are based on a novel methodology which couples molecular motion to a mesoscopic fluid solvent. Thousands of events of…

生物物理 · 物理学 2015-05-13 Maria Fyta , Simone Melchionna , Massimo Bernaschi , Efthimios Kaxiras , Sauro Succi

Correlation length exponent $\nu$ for long linear DNA molecules was determined by direct measurement of the average end-to-end distance as a function of the contour length $s$ by means of atomic force microscopy (AFM). Linear DNA, up to…

软凝聚态物质 · 物理学 2009-11-11 Francesco Valle , Melanie Favre , Paolo De Los Rios , Angelo Rosa , Giovanni Dietler

We employ a three-dimensional molecular dynamics to simulate translocation of a polymer through a nanopore driven by an external force. The translocation is investigated for different three pore diameter and two different external forces.…

计算物理 · 物理学 2019-12-03 Mohammadreza Niknam Hamidabad , Rouhollah Haji Abdolvahab

Force-driven translocation of a macromolecule through a nanopore is investigated by taking into account the monomer-pore friction as well as the "crowding" of monomers on the {\it trans} - side of the membrane which counterbalance the…

软凝聚态物质 · 物理学 2014-10-06 Johan L. A. Dubbeldam , V. G. Rostiashvili , T. A. Vilgis

We study how double-stranded DNA translocates through graphene nanogaps. Nanogaps are fabricated with a novel capillary-force induced graphene nanogap formation technique. DNA translocation signatures for nanogaps are qualitatively…

We present micro-rheological measurments of the drag force on colloids pulled through a solution of lambda-DNA (used here as a monodisperse model polymer) with an optical tweezer. The experiments show a violation of the Stokes-Einstein…

软凝聚态物质 · 物理学 2009-11-13 Christof Gutsche , Friedrich Kremer , Matthias Krüger , Markus Rauscher , Rudolf Weeber , Jens Harting

A double stranded DNA molecule under the stress of a pulling force acting on the strand terminals exhibits a partially denatured structure or can be completely unzipped depending the magnitude of the pulling force. A scaling argument for…

统计力学 · 物理学 2009-09-25 Jeff Z. Y. Chen

Quantum transport for DNA conduction has widely studied with interest in application as a candidate in making nanowires as well as interest in the scientific mechanism. In this paper, we review recent works with concerning the electronic…

无序系统与神经网络 · 物理学 2015-03-13 Hiroaki Yamada , Kazumoto Iguchi

The translocation of a short DNA fragment through a nanopore is addressed when the perforated membrane contains an embedded electrode. Accurate numerical solutions of the coupled Poisson, Nernst-Planck, and Stokes equations for a realistic,…

软凝聚态物质 · 物理学 2017-06-29 Thomas Töws , Peter Reimann