相关论文: On Population Kinetics of an Aging Society: Aging …
Mortality is an instrument of natural selection. Evolutionary motivated theories imply its irreversibility and life history dependence. This is inconsistent with mortality data for protected populations. Accurate analysis yields mortality…
At any moment in time, evolution is faced with a formidable challenge: refining the already highly optimised design of biological species, a feat accomplished through all preceding generations. In such a scenario, the impact of random…
Ignoring the differences between countries, human reproductive and dispersal behaviors can be described by some standardized models, so whether there is a universal law of population growth hidden in the abundant and unstructured data from…
It is now increasingly realized that the underlying mechanism which governs aging (ageing) is a complex interplay of genetic regulation and damage-accumulation. "Aging as a result of accumulation of 'faults' on cellular and molecular…
Motivated by the wide range of known self-replicating systems, some far from genetics, we study a system composed by individuals having an internal dynamics with many possible states that are partially stable, with varying mutation rates.…
Disgust is a basic emotion that serves to avoid contaminants, and is central to the behavioural immune system. While disgust-motivated avoidance occurs in bonobos and chimpanzees, humans show uniquely high levels of contamination…
Throughout history, for reasons of health, well known personalities have opted not to eat to satiety - to under-eat - with known benefits. Here, for the benefits of under-eating a very simple explanation is offered and discussed in some…
Coronary artery disease, heart failure, angina pectoris and diabetes are among the leading causes of morbidity and mortality over the globe. Susceptibility to such disorders is compounded by changing lifestyles, poor dietary routines, aging…
A simple evolutionary model for biological ageing is modified such that it requires a minimum population for survival, like in human society. This social effect leads to a transition between extinction and survival of the species.
Is cancer a disease that can be cured or a degenerative disease which comes predominantly with old age? We give an answer based on a two-dimensional representation of diseases. These two dimensions are defined as follows. In mortality…
We recently introduced Misrepair-accumulation theory as an interpretation on aging mechanism. For better understanding this theory, we discuss here in more details the new concept of Misrepair and the concept of accumulation of Misrepairs.…
Many theories have been proposed to answer two questions on aging: "Why do we age?" and "How do we age?" Among them, evolutionary theories are proposed to interpret the evolutionary advantage of aging, and "saving resources for group…
How long people live depends on their health, and how it changes with age. Individual health can be tracked by the accumulation of age-related health deficits. The fraction of age-related deficits is a simple quantitative measure of human…
Aggregated health data such as claims data from health insurances become more and more available for research purposes. Estimates of excess mortality from prevalence and incidence of a chronic condition have only been possible for ages 50…
The study considers the model of an abstract organism, called Arbitrary Oscillator (ArbO), which is capable of making decisions at each timed step. These decisions are 'critical' since, randomly, their outcome can be 'fatal' for ArbO, thus…
Models of many-species ecosystems, such as the Lotka-Volterra and replicator equations, suggest that these systems generically exhibit near-extinction processes, where population sizes go very close to zero for some time before rebounding,…
Existing theories for the evolution of aging and death treat senescence as a side-effect of strong selection for fertility. These theories are well-developed mathematically, but fit poorly with emerging experimental data. The data suggest…
Rapid increases in food supplies have reduced global hunger, while rising burdens of diet-related disease have made poor diet quality the leading cause of death and disability around the world. Today's "double burden" of undernourishment in…
We examine the dynamics of an age-structured population model in which the life expectancy of an offspring may be mutated with respect to that of the parent. While the total population of the system always reaches a steady state, the…
The human spine is a complex structure composed of 33 vertebrae. It holds the body and is important for leading a healthy life. The spine is vulnerable to age-related degenerations that can be identified through magnetic resonance imaging…