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Aging, the process of growing old or maturing, is one of the most widely seen natural phenomena in the world. For the stochastic processes, sometimes the influence of aging can not be ignored. For example, in this paper, by analyzing the…

化学物理 · 物理学 2017-11-30 Wanli Wang , Weihua Deng

Aging is a multifactorial process and a key factor of morbidity and mortality. Alzheimer's disease (AD) is an age-related disorder and a main cause of worldwide disability. Both aging and AD can be characterized by metabolic dysfunction.…

基因组学 · 定量生物学 2022-12-21 Yiming Li , Yuan Luo

Non-communicable diseases like diabetes, obesity and certain forms of cancer have been increasing in many countries at alarming levels. A difficulty in the conception of policies to reverse these trends is the identification of the drivers…

物理与社会 · 物理学 2016-03-29 Lazaros K. Gallos , Pablo Barttfeld , Shlomo Havlin , Mariano Sigman , Hernan A. Makse

Following the recent publication of our book on Exploring the Health State of a Population by Dynamic Modeling Methods in The Springer Series on Demographic Methods and Population Analysis (DOI 10.1007/978-3-319-65142-2) we provide this…

定量方法 · 定量生物学 2017-11-28 Christos H Skiadas , Charilaos Skiadas

Aging, as defined in terms of the slope of the probability of death versus time (hazard curve), is a generic phenomenon observed in nearly all complex systems. Theoretical models of aging predict hazard curves that monotonically increase in…

生物物理 · 物理学 2023-12-20 Cagatay Eskin , Dervis C. Vural

Complex fluids exhibit time-dependent changes in viscosity that have been ascribed to both thixotropy and aging. However, there is no consensus for which phenomenon is the origin of which changes. A novel thixotropic model is defined that…

软凝聚态物质 · 物理学 2008-08-26 Daniel Quemada

Emerging empirical and theoretical thinking about human aging places considerable value upon the role of the environment as a major factor which can promote prolonged healthy longevity. Our contemporary, information-rich environment is…

其他定量生物学 · 定量生物学 2014-07-24 Marios Kyriazis

Aging is a multidimensional process where phenotypes change at varying rates. Longitudinal studies of aging typically involve following a cohort of individuals over the course of several years. This design is hindered by cost, attrition,…

Motivated by recent research of aging in E. coli, we explore the effects of aging on bacterial fitness. The disposable soma theory of aging was developed to explain how differences in lifespans and aging rates could be linked to life…

种群与进化 · 定量生物学 2007-05-23 Leah R. Johnson , Marc Mangel

Human life expectancy has dramatically improved over the course of the last century. Although this reflects a global improvement in sanitation and medical care, this also implies that more people suffer from diseases that typically manifest…

其他定量生物学 · 定量生物学 2022-07-11 Alexis Rapin , Maroun Bou Sleiman , Johan Auwerx

Lifespan distributions of populations of quite diverse species such as humans and yeast seem to surprisingly well follow the same empirical Gompertz-Makeham law, which basically predicts an exponential increase of mortality rate with age.…

定量方法 · 定量生物学 2011-10-18 André Grüning , Aasis Vinayak PG

Background: The relative contribution of different aging-associated processes to the age phenotype may differ among individuals, creating variability in aging manifestations among age-peers. Capturing this variability can significantly…

种群与进化 · 定量生物学 2007-05-23 A. Kulminski , A. Yashin , S. Ukraintseva , I. Akushevich , K. Arbeev , K. Land , K. Manton

We demonstrate via several examples that a uniform drift velocity gives rise to anomalous aging, characterized by a specific form for the two-time correlation functions, in a variety of statistical-mechanical systems far from equilibrium.…

统计力学 · 物理学 2009-10-31 J. M. Luck , Anita Mehta

Under rapid undercooling, glass forming liquids freeze in an amorphous state that can equilibrate only on enormously long time-scales, This is the characteristic sign of aging, which has been observed in a wide range of systems. Brownian…

As the global population ages, there is increased interest in living longer and improving one's quality of life in later years. However, studying aging - the decline in body function - is expensive and time-consuming. And despite research…

其他定量生物学 · 定量生物学 2019-04-23 Sandeep Kumar , Timothy R. Peterson

The analysis of the demographic transition of the past century and a half, using both empirical data and mathematical models, has rendered a wealth of well-established facts, including the dramatic increases in life expectancy. Despite…

种群与进化 · 定量生物学 2018-07-02 Albert Solé-Ribalta , Javier Borge-Holthoefer

We have all read that: (1) organized medicine was laughing at the germ theory and refused to wash its hands in the late 1800's while women died of childbed fever and other patients of wound sepsis (scientists in general, including…

物理与社会 · 物理学 2007-05-23 John T. A. Ely

Reduced motor control is one of the most frequent features associated with aging and disease. Nonlinear and fractal analyses have proved to be useful in investigating human physiological alterations with age and disease. Similar findings…

Tissue fibrosis is the phenomenon that a tissue has progressive deposition of collagen fibers with age. Tissue fibrosis is associated with aging of most of our organs, and it is the main pathology in arteriosclerosis, chronic…

组织与器官 · 定量生物学 2017-09-07 Jicun Wang-Michelitsch , Thomas M. Michelitsch

Cellular senescence is thought to play a major role in age-related diseases, which cause nearly 67% of all human deaths worldwide. Recent research in mice showed that exercising mice had higher levels of telomerase, an enzyme that helps…

种群与进化 · 定量生物学 2013-11-13 Avikar Periwal