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We study theoretical ``design principles'' for transcription factor-DNA interaction in bacteria, focusing particularly on the statistical interaction of the transcription factors (TF's) with the genomic background (i.e., the genome without…

生物物理 · 物理学 2009-11-07 Ulrich Gerland , J. David Moroz , Terence Hwa

In solution, electrically like-charged particles can experience a strong and long-ranged attraction that leads to the formation of stable, slowly reorganizing clusters. The attractive force underpinning this spontaneous organization process…

软凝聚态物质 · 物理学 2026-01-14 Sida Wang , Angela Le , Rowan Walker-Gibbons , Madhavi Krishnan

We demonstrate simultaneous measurements of DNA translocation into glass nanopores using ionic current detection and fluorescent imaging. We verify the correspondence between the passage of a single DNA molecule through the nanopore and the…

One of the main goals of DNA nanotechnology is to provide a viable solution to the limitations of top-down approaches in microfabrication schemes. Although a completely practical bottom-up approach is yet to be realized, there has been…

材料科学 · 物理学 2011-11-15 Junwye Lee , Sunho Kim , Junghoon Kim , Chang-Won Lee , Yonghan Roh , Sung Ha Park

Patterning graphene into various mesoscopic devices such as nanoribbons, quantum dots, etc. by lithographic techniques has enabled the guiding and manipulation of graphene's Dirac-type charge carriers. Graphene, with well-defined strain…

介观与纳米尺度物理 · 物理学 2017-06-09 Péter Nemes-Incze , Gergő Kukucska , János Koltai , Jenő Kürti , Chanyong Hwang , Levente Tapasztó , László P. Biró

The macroscopic curvature induced in double helical B-DNA by regularly repeated adenine tracts (A-tracts) is a long known, but still unexplained phenomenon. This effect plays a key role in DNA studies because it is unique in the amount and…

生物物理 · 物理学 2007-05-23 Alexey K. Mazur

DNA shape readout is an important mechanism of target site recognition by transcription factors, in addition to the sequence readout. Several models of transcription factor-DNA binding which consider DNA shape have been developed in recent…

生物大分子 · 定量生物学 2017-11-30 Kirill Batmanov , Junbai Wang

In atomic force microscopy (AFM) tip-surface interactions are usually considered as functions of the tip position only, so-called force curves. However, tip-surface interactions often depend on the tip velocity and the past tip trajectory.…

介观与纳米尺度物理 · 物理学 2013-01-31 Daniel Platz , Daniel Forchheimer , Erik A. Tholén , David B. Haviland

Molecular dynamics simulations have been performed to understand true atomic resolution, which has been observed on the Si(111)-7$\times$7 surface by dynamic force microscopy in ultra high vacuum(UHV). Stable atomic-scale contrast is…

材料科学 · 物理学 2009-10-31 Abduxukur Abdurixit , Alexis Baratoff , Ernest Meyer

In the present paper we address the general problem of selective electrodynamic interactions between DNA and protein, which is motivated by decades of theoretical study and our very recent experimental findings (M. Lechelon et al,…

生物物理 · 物理学 2024-12-18 E. Faraji , P. Kurian , R. Franzosi , S. Mancini , E. Floriani , V. Calandrini , G. Pettini , M. Pettini

Since the inception of the atomic force microscope AFM, dynamic methods have been very fruitful by establishing methods to quantify dissipative and conservative forces in the nanoscale and by providing a means to apply gentle forces to the…

介观与纳米尺度物理 · 物理学 2021-04-14 Sergio Santos , Karim Gadelrab , Chia-Yun Lai , Tuza Olukan , Josep Font , Victor Barcons , Albert Verdaguer , Matteo Chiesa

Graphene and related two-dimensional (2D) materials associate remarkable mechanical, electronic, optical and phononic properties. As such, 2D materials are promising for hybrid systems that couple their elementary excitations (excitons,…

介观与纳米尺度物理 · 物理学 2020-11-06 Xin Zhang , Kevin Makles , Léo Colombier , Dominik Metten , Hicham Majjad , Pierre Verlot , Stéphane Berciaud

Optical properties of graphene are explored by using the generalized tight-binding model. The main features of spectral structures, the form, frequency, number and intensity, are greatly enriched by the complex relationship among the…

计算物理 · 物理学 2016-07-20 Chiun-Yan Lin , Thi-Nga Do , Yao-Kung Huang , Ming-Fa Lin

Supported Lipid Bilayers (SLBs) are model membranes formed at solid substrate surfaces. This architecture renders the membrane experimentally accessible to surface sensitive techniques used to study their properties, including Atomic Force…

生物物理 · 物理学 2019-11-19 James A. Goodchild , Danielle L. Walsh , Simon D. Connell

We used a complete tight-binding band structure of graphene nanoribbon to obtain, for the first time, analytical techniques for observing photon assisted transport, and dynamic localization of electrons in the graphene nanoribbons. When the…

材料科学 · 物理学 2012-02-17 M. Rabiu , S. Y. Mensah , S. S. Abukari

Efficient capture and detection of minute amount of deoxyribonucleic acid (DNA) molecules are pivotal for an array of modern gene technologies which are widely utilized in medical, forensic and defense applications, including DNA…

生物物理 · 物理学 2018-11-19 Jianhe Guo , Kwanoh Kim , Peter Vandeventer , Donglei , Fan

In this paper we show that a dynamical description of the protein folding process provides an effective representation of equilibrium properties and it allows for a direct investigation of the mechanisms ruling the approach towards the…

统计力学 · 物理学 2007-05-23 Alessandro Torcini , Roberto Livi , Antonio Politi

Multivalent interactions between deformable mesoscopic units are ubiquitous in biology, where membrane macromolecules mediate the interactions between neighbouring living cells and between cells and solid substrates. Lately, analogous…

生物物理 · 物理学 2015-04-20 S. F. Shimobayashi , B. M. Mognetti , L. Parolini , D. Orsi , P. Cicuta , L. Di Michele

DNA-coated particles are promising as building blocks for functional and finite-sized assemblies because they can be programmed with orthogonal interactions owing to the sequence-specific hybridization of DNA strands. To fully exploit this…

软凝聚态物质 · 物理学 2026-04-17 T. C. M. Stevens , A. van der Sluis , I. K. Voets , P. G. Moerman

A dynamical model is presented for chiral change in DNA molecules. The model is an extension of the conventional elastic model which incorporates the structure of base pairs and uses a spinor representation for the DNA configuration…

生物物理 · 物理学 2011-10-06 Teruaki Okushima , Hiroshi Kuratsuji