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Controlling the false discovery rate (FDR) in high-dimensional variable selection requires balancing rigorous error control with statistical power. Existing methods with provable guarantees are often overly conservative, creating a…

统计方法学 · 统计学 2026-02-06 Arnau Vilella , Jasin Machkour , Michael Muma , Daniel P. Palomar

Selecting relevant features associated with a given response variable is an important issue in many scientific fields. Quantifying quality and uncertainty of a selection result via false discovery rate (FDR) control has been of recent…

统计方法学 · 统计学 2020-12-17 Chenguang Dai , Buyu Lin , Xin Xing , Jun S. Liu

The steep rise in availability and usage of high-throughput technologies in biology brought with it a clear need for methods to control the False Discovery Rate (FDR) in multiple tests. Benjamini and Hochberg (BH) introduced in 1995 a…

统计方法学 · 统计学 2011-08-11 Amit Zeisel , Or Zuk , Eytan Domany

Large-scale multiple testing is a fundamental problem in high dimensional statistical inference. It is increasingly common that various types of auxiliary information, reflecting the structural relationship among the hypotheses, are…

统计方法学 · 统计学 2021-10-07 Hongyuan Cao , Jun Chen , Xianyang Zhang

The problem of multiple hypothesis testing arises when there are more than one hypothesis to be tested simultaneously for statistical significance. This is a very common situation in many data mining applications. For instance, assessing…

机器学习 · 统计学 2009-06-30 Sami Hanhijärvi , Kai Puolamäki , Gemma C. Garriga

This paper is concerned with false discovery rate (FDR) control in large-scale multiple testing problems. We first propose a new data-driven testing procedure for controlling the FDR in large-scale t-tests for one-sample mean problem. The…

统计理论 · 数学 2020-03-02 Changliang Zou , Haojie Ren , Xu Guo , Runze Li

This article considers the problem of multiple hypothesis testing using $t$-tests. The observed data are assumed to be independently generated conditional on an underlying and unknown two-state hidden model. We propose an asymptotically…

统计理论 · 数学 2011-02-22 Hongyuan Cao , Michael R. Kosorok

Complex large-scale studies, such as those related to microarray data and fMRI studies, often involve testing multiple hierarchically ordered hypotheses. However, most existing false discovery rate (FDR) controlling procedures do not…

统计方法学 · 统计学 2016-12-15 Gavin Lynch , Wenge Guo

In many scenarios such as genome-wide association studies where dependences between variables commonly exist, it is often of interest to infer the interaction effects in the model. However, testing pairwise interactions among millions of…

统计方法学 · 统计学 2022-09-02 Jingyi Duan , Yang Ning , Xi Chen , Yong Chen

Controlling false discovery rate (FDR) while leveraging the side information of multiple hypothesis testing is an emerging research topic in modern data science. Existing methods rely on the test-level covariates while ignoring possible…

机器学习 · 统计学 2021-01-26 Lin Qiu , Nils Murrugarra-Llerena , Vítor Silva , Lin Lin , Vernon M. Chinchilli

We consider controlling the false discovery rate for testing many time series with an unknown cross-sectional correlation structure. Given a large number of hypotheses, false and missing discoveries can plague an analysis. While many…

统计方法学 · 统计学 2021-06-10 Junpei Komiyama , Masaya Abe , Kei Nakagawa , Kenichiro McAlinn

We propose sufficient conditions and computationally efficient procedures for false discovery rate control in multiple testing when the $p$-values are related by a known \emph{dependency graph} -- meaning that we assume independence of…

统计方法学 · 统计学 2025-07-01 Drew T. Nguyen , William Fithian

The present paper establishes new multiple procedures for simultaneous testing of a large number of hypotheses under dependence. Special attention is devoted to experiments with rare false hypotheses. This sparsity assumption is typically…

统计理论 · 数学 2019-10-01 Marc Ditzhaus , Arnold Janssen

While data-driven confounder selection requires careful consideration, it is frequently employed in observational studies. Widely recognized criteria for confounder selection include the minimal-set approach, which involves selecting…

统计方法学 · 统计学 2025-08-21 Kazuharu Harada , Masataka Taguri

False discovery rate (FDR) is a cornerstone of modern multiple testing. However, it often fails to guarantee the reliability of "marginal" discoveries that lie at the boundary of the rejection set, which are often crucial in high-precision…

统计方法学 · 统计学 2026-05-12 Yifan Zhang , Wentao Zhang , Changliang Zou , Haojie Ren

In the setting of multiple testing, compound p-values generalize p-values by asking for superuniformity to hold only \emph{on average} across all true nulls. We study the properties of the Benjamini--Hochberg procedure applied to compound…

统计理论 · 数学 2025-07-30 Rina Foygel Barber , Richard J Samworth

Some effort has been undertaken over the last decade to provide conditions for the control of the false discovery rate by the linear step-up procedure (LSU) for testing $n$ hypotheses when test statistics are dependent. In this paper we…

统计理论 · 数学 2007-10-18 Helmut Finner , Thorsten Dickhaus , Markus Roters

When testing a number of statistical hypotheses using data from location families, it is often useful to control the false discovery rate (FDR) not just for hypotheses of the null values but also of other parameter values that are deemed…

统计方法学 · 统计学 2026-05-12 Zijun Gao , Wenjie Hu , Qingyuan Zhao

In a one-way analysis-of-variance (ANOVA) model, the number of all pairwise comparisons can be large even when there are only a moderate number of groups. Motivated by this, we consider a regime with a growing number of groups, and prove…

统计理论 · 数学 2023-12-12 Weidong Liu , Dennis Leung , Qiman Shao

Empirical research in the social and medical sciences frequently involves testing multiple hypotheses simultaneously, increasing the risk of false positives due to chance. Classical multiple testing procedures, such as the Bonferroni…

计量经济学 · 经济学 2025-07-29 Sebastian Calonico , Sebastian Galiani