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Recent substantial advances of molecular targeted oncology drug development is requiring new paradigms for early-phase clinical trial methodologies to enable us to evaluate efficacy of several subtypes simultaneously and efficiently. The…

统计方法学 · 统计学 2023-02-17 Satoshi Hattori , Satoshi Morita

Intuitively, sampling is likely to be more efficient for prevalence estimation, if the cases (or positives) have a relatively higher representation in the sample than in the population. In case the virus is transmitted via personal…

应用统计 · 统计学 2020-11-18 Li-Chun Zhang

The Mantel-Haenszel (MH) risk difference estimator, commonly used in randomized clinical trials for binary outcomes, calculates a weighted average of stratum-specific risk difference estimators. Traditionally, this method requires the…

统计方法学 · 统计学 2025-05-12 Xiaoyu Qiu , Yuhan Qian , Jaehwan Yi , Jinqiu Wang , Yu Du , Yanyao Yi , Ting Ye

Epidemiologists increasingly use causal inference methods that rely on machine learning, as these approaches can relax unnecessary model specification assumptions. While deriving and studying asymptotic properties of such estimators is a…

统计方法学 · 统计学 2025-02-11 Audrey Renson , Lina Montoya , Dana E. Goin , Iván Díaz , Rachael K. Ross

We observe a random measure $N$ and aim at estimating its intensity $s$. This statistical framework allows to deal simultaneously with the problems of estimating a density, the marginals of a multivariate distribution, the mean of a random…

统计理论 · 数学 2009-05-12 Yannick Baraud

A common problem in health research is that we have a large database with many variables measured on a large number of individuals. We are interested in measuring additional variables on a subsample; these measurements may be newly…

统计方法学 · 统计学 2022-03-22 Thomas Lumley , Tong Chen

Survey sampling theory and methods are introduced. Sampling designs and estimation methods are carefully discussed as a textbook for survey sampling. Topics includes Horvitz-Thompson estimation, simple random sampling, stratified sampling,…

统计方法学 · 统计学 2024-12-03 Jae Kwang Kim

We examine study designs for extending (generalizing or transporting) causal inferences from a randomized trial to a target population. Specifically, we consider nested trial designs, where randomized individuals are nested within a sample…

Binary endpoints are common in clinical trials and conditional odds ratios have traditionally been used to assess treatment effects. However, the interpretation of odds ratios is difficult, they are non-collapsible and rely on strong…

统计方法学 · 统计学 2026-05-20 Martin Schnuerch , Alex Ocampo , Klaus Kähler Holst , Christian Stock

We establish the asymptotic normality of the regression estimator in a fixed-design setting when the errors are given by a field of dependent random variables. The result applies to martingale-difference or strongly mixing random fields. On…

统计理论 · 数学 2009-07-10 Mohamed El Machkouri , Radu Stoica

The Kaplan-Meier product-limit estimator is a simple and powerful tool in time to event analysis. An extension exists for populations stratified into cohorts where a population survival curve is generated by weighted averaging of…

统计方法学 · 统计学 2018-11-12 Aaron Heuser , Minh Huynh , Joshua C. Chang

Many enumeration problems in combinatorics, including such fundamental questions as the number of regular graphs, can be expressed as high-dimensional complex integrals. Motivated by the need for a systematic study of the asymptotic…

组合数学 · 数学 2017-12-29 Mikhail Isaev , Brendan D. McKay

Considerable interest has recently been focused on studying multiple phenotypes simultaneously in both epidemiological and genomic studies, either to capture the multidimensionality of complex disorders or to understand shared etiology of…

统计方法学 · 统计学 2015-11-26 Denis Agniel , Katherine P. Liao , Tianxi Cai

The martingale expansion provides a refined approximation to the marginal distributions of martingales beyond the normal approximation implied by the martingale central limit theorem. We develop a martingale expansion framework specifically…

概率论 · 数学 2026-02-06 Masaaki Fukasawa

Bipartite incidence graph sampling provides a unified representation of many sampling situations for the purpose of estimation, including the existing unconventional sampling methods, such as indirect, network or adaptive cluster sampling,…

统计理论 · 数学 2020-04-10 Martina Patone , Li-Chun Zhang

The maxima and the minima of a randomly stopped sample of a random variable, $X$, together with two newly defined random variables that make $X$ into the maxima or minima of a randomly stopped sample of them, can be used to define…

统计理论 · 数学 2024-12-23 Jordi Valero , Josep Ginebra

Recent works have proposed optimal subsampling algorithms to improve computational efficiency in large datasets and to design validation studies in the presence of measurement error. Existing approaches generally fall into two categories:…

统计方法学 · 统计学 2025-12-25 Jasper B. Yang , Thomas Lumley , Bryan E. Shepherd , Pamela A. Shaw

Non-probability samples become increasingly popular in survey statistics but may suffer from selection biases that limit the generalizability of results to the target population. We consider integrating a non-probability sample with a…

统计方法学 · 统计学 2019-08-26 Shu Yang , Jae Kwang Kim , Rui Song

To tackle massive data, subsampling is a practical approach to select the more informative data points. However, when responses are expensive to measure, developing efficient subsampling schemes is challenging, and an optimal sampling…

统计计算 · 统计学 2022-10-11 Jing Wang , HaiYing Wang , Shifeng Xiong

Structured additive distributional regression models offer a versatile framework for estimating complete conditional distributions by relating all parameters of a parametric distribution to covariates. Although these models efficiently…

统计方法学 · 统计学 2023-11-14 Jana Kleinemeier , Nadja Klein
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