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The false discovery rate (FDR) and the false non-discovery rate (FNR), defined as the expected false discovery proportion (FDP) and the false non-discovery proportion (FNP), are the most popular benchmarks for multiple testing. Despite the…

统计理论 · 数学 2025-09-03 Yutong Nie , Yihong Wu

Improved procedures, in terms of smaller missed discovery rates (MDR), for performing multiple hypotheses testing with weak and strong control of the family-wise error rate (FWER) or the false discovery rate (FDR) are developed and studied.…

统计理论 · 数学 2011-03-10 Edsel A. Peña , Joshua D. Habiger , Wensong Wu

When hypotheses are tested in a stream and real-time decision-making is needed, online sequential hypothesis testing procedures are needed. Furthermore, these hypotheses are commonly partitioned into groups by their nature. For example, the…

统计方法学 · 统计学 2025-06-05 Runqiu Wang , Ran Dai

Out of the participants in a randomized experiment with anticipated heterogeneous treatment effects, is it possible to identify which subjects have a positive treatment effect? While subgroup analysis has received attention, claims about…

统计方法学 · 统计学 2024-05-14 Boyan Duan , Larry Wasserman , Aaditya Ramdas

This paper studies the semi-supervised novelty detection problem where a set of "typical" measurements is available to the researcher. Motivated by recent advances in multiple testing and conformal inference, we propose AdaDetect, a…

统计方法学 · 统计学 2023-10-26 Ariane Marandon , Lihua Lei , David Mary , Etienne Roquain

The PC algorithm allows investigators to estimate a complete partially directed acyclic graph (CPDAG) from a finite dataset, but few groups have investigated strategies for estimating and controlling the false discovery rate (FDR) of the…

机器学习 · 统计学 2017-05-11 Eric V. Strobl , Peter L. Spirtes , Shyam Visweswaran

The genetic basis of multiple phenotypes such as gene expression, metabolite levels, or imaging features is often investigated by testing a large collection of hypotheses, probing the existence of association between each of the traits and…

应用统计 · 统计学 2015-04-06 Christine Peterson , Marina Bogomolov , Yoav Benjamini , Chiara Sabatti

In the online multiple testing problem, p-values corresponding to different null hypotheses are observed one by one, and the decision of whether or not to reject the current hypothesis must be made immediately, after which the next p-value…

统计方法学 · 统计学 2017-10-03 Aaditya Ramdas , Fanny Yang , Martin J. Wainwright , Michael I. Jordan

False discovery rate (FDR) is commonly used for correction for multiple testing in neuroimaging studies. However, when using two-tailed tests, making directional inferences about the results can lead to a vastly inflated error rate, even…

统计方法学 · 统计学 2025-12-16 Anderson M. Winkler , Paul A. Taylor , Thomas E. Nichols , Chris Rorden

In large scale multiple testing problems, a two-class empirical Bayes approach can be used to control the false discovery rate (Fdr) for the entire array of hypotheses under study. A sample splitting step is incorporated to modify that…

统计计算 · 统计学 2019-12-13 Paramita Chakraborty , Chong Ma , John Grego , James Lynch

In this article we develop a method for performing post hoc inference of the False Discovery Proportion (FDP) over multiple contrasts of interest in the multivariate linear model. To do so we use the bootstrap to simulate from the…

统计方法学 · 统计学 2022-09-21 Samuel Davenport , Bertrand Thirion , Pierre Neuvial

In the multiple testing problem with independent tests, the classical linear step-up procedure controls the false discovery rate (FDR) at level $\pi_0\alpha$, where $\pi_0$ is the proportion of true null hypotheses and $\alpha$ is the…

统计方法学 · 统计学 2019-08-29 Peter MacDonald , Kun Liang , Arnold Janssen

In many multiple testing applications in genetics, the signs of test statistics provide useful directional information, such as whether genes are potentially up- or down-regulated between two experimental conditions. However, most existing…

统计方法学 · 统计学 2025-07-22 Zhaoyang Tian , Kun Liang , Pengfei Li

When testing multiple hypotheses, a suitable error rate should be controlled even in exploratory trials. Conventional methods to control the False Discovery Rate (FDR) assume that all p-values are available at the time point of test…

统计方法学 · 统计学 2021-12-21 Sonja Zehetmayer , Martin Posch , Franz Koenig

Several classical methods exist for controlling the false discovery exceedance (FDX) for large scale multiple testing problems, among them the Lehmann-Romano procedure ([LR] below) and the Guo-Romano procedure ([GR] below). While these two…

统计方法学 · 统计学 2019-12-11 Sebastian Döhler , Etienne Roquain

Most link prediction methods return estimates of the connection probability of missing edges in a graph. Such output can be used to rank the missing edges from most to least likely to be a true edge, but does not directly provide a…

统计方法学 · 统计学 2024-03-26 Ariane Marandon

With the rapid growth of crowdsourcing platforms it has become easy and relatively inexpensive to collect a dataset labeled by multiple annotators in a short time. However due to the lack of control over the quality of the annotators, some…

机器学习 · 统计学 2016-06-17 Qianqian Xu , Jiechao Xiong , Xiaochun Cao , Yuan Yao

The simultaneous analysis of many statistical tests is ubiquitous in applications. Perhaps the most popular error rate used for avoiding type one error inflation is the false discovery rate (FDR). However, most theoretical and software…

统计计算 · 统计学 2019-04-04 Guillermo Durand , Florian Junge , Sebastian Döhler , Etienne Roquain

The knockoff-based multiple testing setup of Barber & Candes (2015) for variable selection in multiple regression where sample size is as large as the number of explanatory variables is considered. The method of Benjamini & Hochberg (1995)…

统计方法学 · 统计学 2021-08-20 Sanat K. Sarkar , Cheng Yong Tang

One important partition of algorithms for controlling the false discovery rate (FDR) in multiple testing is into offline and online algorithms. The first generally achieve significantly higher power of discovery, while the latter allow…

统计方法学 · 统计学 2021-03-05 Tijana Zrnic , Daniel L. Jiang , Aaditya Ramdas , Michael I. Jordan