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Polymerization of dendritic actin networks underlies important mechanical processes in cell biology such as the protrusion of lamellipodia, propulsion of growth cones in dendrites of neurons, intracellular transport of organelles and…

生物物理 · 物理学 2021-03-17 Rohan Abeyaratne , Prashant K. Purohit

The growth dynamics of rigid biopolymers, consisting of $N$ parallel protofilaments, is investigated theoretically using simple approximate models. In our approach, the structure of a polymer's growing end and lateral interactions between…

统计力学 · 物理学 2009-11-10 Evgeny B. Stukalin , Anatoly B. Kolomeisky

Polymerization of actin proteins into dynamic structures is essential to eukaryotic cell life. This has motivated a large body of in vitro experiments measuring polymerization kinetics of individual filaments. Here we model these kinetics,…

生物大分子 · 定量生物学 2009-11-10 Dimitrios Vavylonis , Qingbo Yang , Ben O'Shaughnessy

The polymerization of actin via branching at a cell membrane containing nucleation-promoting factors is simulated using a stochastic-growth methodology. The polymerized-actin distribution displays three types of behavior: a) traveling…

生物物理 · 物理学 2015-05-19 Anders E. Carlsson

Polymerization dynamics of single actin filaments is investigated theoretically using a stochastic model that takes into account the hydrolysis of ATP-actin subunits, the geometry of actin filament tips, the lateral interactions between the…

软凝聚态物质 · 物理学 2009-11-11 Evgeny B. Stukalin , Anatoly B. Kolomeisky

We study the activated motion of adsorbed polymers which are driven over a structured substrate by a localized point force.Our theory applies to experiments with single polymers using, for example, tips of scanning force microscopes to drag…

软凝聚态物质 · 物理学 2009-11-11 P. Kraikivski , R. Lipowsky , J. Kierfeld

Cell spreading is investigated at various scales in order to understand motility of living cells which is essential for a range of physiological activities in higher organisms as well as in microbes. At a microscopic scale, it has been seen…

细胞行为 · 定量生物学 2009-11-13 A. Bhattacharyay

We develop a model to describe the force generated by the polymerization of an array of parallel biofilaments. The filaments are assumed to be coupled only through mechanical contact with a movable barrier. We calculate the filament density…

统计力学 · 物理学 2015-05-20 K. Tsekouras , D. Lacoste , K. Mallick , J. -F. Joanny

Cellular actin dynamics result from collective action of hundreds of regulatory proteins, majority of which target actin filaments at their barbed ends. Three key actin binding proteins - profilin, cofilin and twinfilin individually…

生物物理 · 物理学 2023-11-14 Ankita , Sandeep Choubey , Shashank Shekhar

We present a kinetic model of crystal growth of polymers of finite molecular weight. Experiments help to classify polymer crystallization broadly into two kinetic regimes. One is observed in melts or in high molar mass polymer solutions and…

软凝聚态物质 · 物理学 2009-11-11 Arindam Kundagrami , M. Muthukumar

The long time dynamics of polymeric materials has been extensively studied in the past through various experimental techniques and computer simulations. While computer simulations typically treat generic, simplified models, experiments deal…

软凝聚态物质 · 物理学 2008-09-10 Vagelis A. Harmandaris , Kurt Kremer

Dimerization and subsequent aggregation of polymers and biopolymers often occur under nonequilibrium conditions. When the initial state of the polymer is not collapsed or the final folded native state, the dynamics of dimerization can…

软凝聚态物质 · 物理学 2024-11-19 Sangita Mondal , Ved Mahajan , Biman Bagchi

We present a statistical mechanical study of stiff polymers, motivated by experiments on actin filaments and the considerable current interest in polymer networks. We obtain simple, approximate analytical forms for the force-extension…

软凝聚态物质 · 物理学 2009-11-13 Abhijit Ghosh , Joseph Samuel , Supurna Sinha

We present a novel method to investigate the dynamics of a single semiflexible polymer, subject to anisotropic friction in a viscous fluid. In contrast to previous approaches, we do not rely on a discrete bead-rod model, but introduce a…

生物大分子 · 定量生物学 2009-11-13 Tobias Munk , Oskar Hallatschek , Chris H. Wiggins , Erwin Frey

Anomalous transport and reaction dynamics are considered by providing the theoretical grounds for the possible experimental realization of actin polymerization in comb-like geometry. Two limiting regimes are recovered, depending on the…

软凝聚态物质 · 物理学 2015-02-25 A. Iomin , V. Zaburdaev , T. Pfohl

The polymerization of actin filaments is coupled to the hydrolysis of adenosine triphosphate (ATP), which involves both the cleavage of ATP and the release of inorganic phosphate. We describe hydrolysis by a reduced two-state model with a…

统计力学 · 物理学 2014-12-12 Xin Li , Reinhard Lipowsky , Jan Kierfeld

Polymers consisting of more than one type of monomer, known as copolymers, are vital to both living and synthetic systems. Copolymerisation has been studied theoretically in a number of contexts, often by considering a Markov process in…

The characterization of the interactions between two fully flexible self-avoiding polymers is one of the classic and most important problems in polymer physics. In this paper we measure these interactions in the presence of active…

软凝聚态物质 · 物理学 2022-04-06 M. C. Gandikota , A. Cacciuto

In this work, we compare the structural and dynamic behavior of active filaments in two dimensions using tangential and push-pull models, including a variant with passive end monomers. These models serve as valuable frameworks for…

We have studied the aging effect on the dynamics of unbinding of a double stranded directed polymer in a random medium. By using the Monte Carlo dynamics of a lattice model in two dimensions, for which disorder is known to be relevant, the…

软凝聚态物质 · 物理学 2009-10-30 Somendra M. Bhattacharjee , A. Baumgärtner
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