相关论文: Applications and Sexual Version of a Simple Model …
A square lattice is introduced into the Penna model for biological aging in order to study the evolution of diploid sexual populations under certain conditions when one single locus in the individual's genome is considered as identifier of…
The sexual version of the Penna model of biological ageing, simulated since 1996, is compared here with alternative forms of reproduction as well as with models not involving ageing. In particular we want to check how sexual forms of life…
We present a simple model for biological aging. We studied it through computer simulations and we have found this model to reflect some features of real populations.
The Penna model is a model of evolutionary ageing through mutation accumulation where traditionally time and the age of an organism are treated as discrete variables and an organism's genome by a binary bit string. We reformulate the…
The Penna model is a strategy to simulate the genetic dynamics of age-structured populations, in which the individuals genomes are represented by bit-strings. It provides a simple metaphor for the evolutionary process in terms of the…
In 1995 T.J.Penna introduced a simple model of biological aging. A modified Penna model has been demonstrated to exhibit behaviour of real-life systems including catastrophic senescence in salmon and a mortality plateau at advanced ages. We…
We generalize the standard Penna bit-string model of biological ageing by assuming that each deleterious mutation diminishes the survival probability in every time interval by a small percentage. This effect is added to the usual lethal but…
It is shown that if the computer model of biological ageing proposed by Stauffer is modified such that the late reproduction is privileged then the Gompertz law of exponential increase of mortality can be retrieved.
The Gompertz law of dependence of human mortality rate on age is derived from a simple model of death as a result of the exponentially rare escape of abnormal cells from immunological response.
The standard Penna ageing model with sexual reproduction is enlarged by adding additional bit-strings for love: Marriage happens only if the male love strings are sufficiently different from the female ones. We simulate at what level of…
A stochastic genetic model for biological aging is introduced bridging the gap between the bit-string Penna model and the Pletcher-Neuhauser approach. The phenomenon of exponentially increasing mortality function at intermediate ages and…
We present some analytic results for the steady states of the Penna model of sen escence, generalised to allow genetically identical individuals to die at differ ent ages via an arbitrary survival function. Modelling this with a Fermi…
In this paper we investigate the flexibility of matrix distributions for the modeling of mortality. Starting from a simple Gompertz law, we show how the introduction of matrix-valued parameters via inhomogeneous phase-type distributions can…
We introduce a square lattice into the Penna bit-string model for biological ageing and study the evolution of the spatial distribution of the population considering different strategies of child-care. Two of the strategies are related to…
This review deals with computer simulation of biological ageing, particularly with the Penna model of 1995.
In this paper we consider a generalization to the asexual version of the Penna model for biological aging, where we take a continuous time limit. The genotype associated to each individual is an interval of real numbers over which Dirac…
Can unicellular organisms survive a drastic temperature change, and adapt to it after many generations? In simulations of the Penna model of biological ageing, both extinction and adaptation were found for asexual and sexual reproduction as…
We have simulated demographic changes in the human population using the Penna microscopic model, based on the simple Monte Carlo method. The results of simulations have shown that during a few generations changes in the genetic pool of a…
New models for evolutionary processes of mutation accumulation allow hypotheses about the age-specificity of mutational effects to be translated into predictions of heterogeneous population hazard functions. We apply these models to…
A simple evolutionary model for biological ageing is modified such that it requires a minimum population for survival, like in human society. This social effect leads to a transition between extinction and survival of the species.