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Models for viral populations with high replication error rates (such as RNA viruses) rely on the quasispecies concept, in which mutational pressure beyond the so-called "Error Threshold" leads to a loss of essential genetic information and…

生物物理 · 物理学 2025-02-26 David A. Herrera-Martí

The stochastic Eigen model proposed by Feng et al. (Journal of theoretical biology, 246 (2007) 28) showed that error threshold is no longer a phase transition point but a crossover region whose width depends on the strength of the random…

种群与进化 · 定量生物学 2015-06-02 Duo-Fang Li , Tian-Guang Cao , Jin-Peng Geng , Jian-Zhong Gu , Hai-Long An , Yong Zhan

We investigate the critical behavior of a reaction-diffusion system exhibiting a continuous absorbing-state phase transition. The reaction-diffusion system strictly conserves the total density of particles, represented as a non-diffusive…

统计力学 · 物理学 2009-10-31 Romualdo Pastor-Satorras , Alessandro Vespignani

Understanding the asymptotic behavior of reaction-diffusion (RD) systems is crucial for modeling processes ranging from species coexistence in ecology to biochemical interactions within cells. In this work, we analyze RD systems in which…

动力系统 · 数学 2025-02-18 Carlos Barajas , Jean-Jacques Slotine , Domitilla Del Vecchio

The quasispecies model describes processes related to the origin of life and viral evolutionary dynamics. We discuss how the error catastrophe that reflects the transition from localized to delocalized quasispecies population is affected by…

种群与进化 · 定量生物学 2009-12-31 Nathaniel Wagner , Emmanuel Tannenbaum , Gonen Ashkenasy

High energy scattering in the QCD parton model was recently shown to be a reaction-diffusion process, and thus to lie in the universality class of the stochastic Fisher-Kolmogorov-Petrovsky-Piscounov equation. We recall that the latter…

高能物理 - 唯象学 · 物理学 2008-11-26 R. Enberg , K. Golec-Biernat , S. Munier

Eigen's quasi-species model describes viruses as ensembles of different mutants of a high fitness "master" genotype. Mutants are assumed to have lower fitness than the master type, yet they coexist with it forming the quasi-species. When…

种群与进化 · 定量生物学 2012-02-02 Jose A. Cuesta

We present the first example of a phase transition in a nonequilibrium steady-state that can be argued analytically to be first order. The system of interest is a two-species reaction-diffusion problem whose control parameter is the total…

统计力学 · 物理学 2009-09-25 K. Oerding , F. van Wijland , J. -P. Leroy , H. J. Hilhorst

We consider the quasispecies description of a population evolving in both the "master sequence" landscape (where a single sequence is evolutionarily preferred over all others) and the REM landscape (where the fitness of different sequences…

无序系统与神经网络 · 物理学 2009-10-28 Silvio Franz , Luca Peliti

We present a field theoretic renormalization group study for the critical behaviour of a uniformly driven diffusive system with quenched disorder, which is modelled by different kinds of potential barriers between sites. Due to their…

统计力学 · 物理学 2015-06-25 V. Becker , H. K. Janssen

Quasispecies theory provides the conceptual and theoretical bases for describing the dynamics of biological information of replicators subject to large mutation rates. This theory, initially conceived within the framework of prebiotic…

种群与进化 · 定量生物学 2025-06-26 Edward A. Turner , Francisco Crespo , Josep Sardanyés , Nolbert Morales

Species evolution is essentially a random process of interaction between biological populations and their environments. As a result, some physical parameters in evolution models are subject to statistical fluctuations. In this paper, two…

种群与进化 · 定量生物学 2015-06-02 Duo-Fang Li , Tian-Guang Cao , Jin-Peng Geng , Li-Hua Qiao , Jian-Zhong Gu , Yong Zhan

This paper extends Eigen's quasispecies equations to account for the semiconservative nature of DNA replication. We solve the equations in the limit of infinite sequence length for the simplest case of a static, sharply peaked fitness…

凝聚态物理 · 物理学 2009-11-10 Emmanuel Tannenbaum , Eric J. Deeds , Eugene I. Shakhnovich

The quasi-species equation describes the evolution of the probability that a random individual in a population carries a given genome. Here we map the quasi-species equation for individuals of a self-reproducing population to an ensemble of…

统计力学 · 物理学 2012-06-20 Ginestra Bianconi , Christoph Rahmede

The effects of error propagation in the reproduction of diploid organisms are studied within the populational genetics framework of the quasispecies model. The dependence of the error threshold on the dominance parameter is fully…

无序系统与神经网络 · 物理学 2016-08-31 Domingos Alves , J. F. Fontanari

We investigate Eigen's model for the evolution of the genetic code of microorganisms using a novel method based on population dynamics analysis. This model, for a given number of offspring, determines long-term survival as a function of the…

种群与进化 · 定量生物学 2024-06-21 Hermano Velten , Carlos Felipe Pinheiro , Alcides Castro e Silva

RNA viruses comprise vast populations of closely related, but highly genetically diverse, entities known as quasispecies. Understanding the mechanisms by which this extreme diversity is generated and maintained is fundamental when…

种群与进化 · 定量生物学 2021-05-27 Luiza Guimarães , Diogo Castro , Bruno Gorzoni , Luiz Mario Ramos Janini , Fernando Antoneli

Despite its critical role in the study of earthquake processes, numerical simulation of the entire stages of fault rupture remains a formidable task. The main challenges in simulating a fault rupture process include complex evolution of…

地球物理 · 物理学 2023-08-22 Fan Fei , Md Shumon Mia , Ahmed E. Elbanna , Jinhyun Choo

Co-evolution of two coupled quasispecies is studied, motivated by the competition between viral evolution and adapting immune response. In this co-adaptive model, besides the classical error catastrophe for high virus mutation rates, a…

统计力学 · 物理学 2009-11-07 Christel Kamp , Stefan Bornholdt

We review the application of field-theoretic renormalization group (RG) methods to the study of fluctuations in reaction-diffusion problems. We first investigate the physical origin of universality in these systems, before comparing RG…

统计力学 · 物理学 2007-05-23 Uwe C. Tauber , Martin Howard , Benjamin P. Vollmayr-Lee
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