相关论文: PROTOCOL: Late Interaction Retrieval for Protein H…

Capturing emotions within a conversation plays an essential role in modern dialogue systems. However, the weak correlation between emotions and semantics brings many challenges to emotion recognition in conversation (ERC). Even semantically…

Is there a foreign language describing protein sequences and structures simultaneously? Protein structures, represented by continuous 3D points, have long posed a challenge due to the contrasting modeling paradigms of discrete sequences. To…

Statistical analysis of protein-protein interactions shows anomalously high frequency of homodimers [Ispolatov, I., et al. (2005) Nucleic Acids Res 33, 3629-35]. Furthermore, recent findings [Wright, C.F., et al. (2005) Nature 438, 878-81]…

Large language models (LLMs) exhibit remarkable generative capabilities but often suffer from hallucinations. Retrieval-augmented generation (RAG) offers an effective solution by incorporating external knowledge, but existing methods still…

Multi-modality pre-training paradigm that aligns protein sequences and biological descriptions has learned general protein representations and achieved promising performance in various downstream applications. However, these works were…

Protein-ligand scoring is a central component of structure-based drug design, underpinning molecular docking, virtual screening, and pose optimization. Conventional physics-based energy functions are often computationally expensive,…

Understanding the molecular determinants of specificity in protein-protein interaction is an outstanding challenge of postgenome biology. The availability of large protein databases generated from sequences of hundreds of bacterial genomes…

Relation prediction is a task designed for knowledge graph completion which aims to predict missing relationships between entities. Recent subgraph-based models for inductive relation prediction have received increasing attention, which can…

In cross-modal retrieval tasks, such as image-to-report and report-to-image retrieval, accurately aligning medical images with relevant text reports is essential but challenging due to the inherent ambiguity and variability in medical data.…

We address the problem of weakly supervised object localization where only image-level annotations are available for training object detectors. Numerous methods have been proposed to tackle this problem through mining object proposals.…

Predicting protein properties is paramount for biological and medical advancements. Current protein engineering mutates on a typical protein, called the wild-type, to construct a family of homologous proteins and study their properties.…

Alignment of large language models (LLMs) via SFT and RLHF/DPO typically ignores the global geometry of the representation space, relying instead on local token likelihoods or scalar scores. We view generation as tracing a semantic…

In meta-learning approaches, it is difficult for a practitioner to make sense of what kind of representations the model employs. Without this ability, it can be difficult to both understand what the model knows as well as to make meaningful…

Long context inference scenarios have become increasingly important for large language models, yet they introduce significant computational latency. While prior research has optimized long-sequence inference through operators, model…

Deep models have been widely and successfully used in image manipulation detection, which aims to classify tampered images and localize tampered regions. Most existing methods mainly focus on extracting global features from tampered images,…

Protein representation learning is critical for numerous biological tasks. Recently, large transformer-based protein language models (pLMs) pretrained on large scale protein sequences have demonstrated significant success in sequence-based…

A variety of methods have been proposed for structure similarity calculation, which are called structure alignment or superposition. One major shortcoming in current structure alignment algorithms is in their inherent design, which is based…

Recognizing visual relationships <subject-predicate-object> among any pair of localized objects is pivotal for image understanding. Previous studies have shown remarkable progress in exploiting linguistic priors or external textual…

We present AMES (Approximate Multimodal Enterprise Search), a unified multimodal late interaction retrieval architecture which is backend agnostic. AMES demonstrates that fine-grained multimodal late interaction retrieval can be deployed…

We introduce a protein language model for determining the complete sequence of a peptide based on measurement of a limited set of amino acids. To date, protein sequencing relies on mass spectrometry, with some novel edman degregation based…