相关论文: Chreode: A Cell World Model for One-Step Temporal …

Perception of time from sequentially acquired sensory inputs is rooted in everyday behaviors of individual organisms. Yet, most algorithms for time-series modeling fail to learn dynamics of random event timings directly from visual or audio…

Biological foundation models have shown strong performance in single-cell representation learning by applying transformer architectures directly to gene-expression matrices. However, these approaches predominantly operate in static settings…

Modeling the dynamics from sparsely time-resolved snapshot data is crucial for understanding complex cellular processes and behavior. Existing methods leverage optimal transport, Schr\"odinger bridge theory, or their variants to…

Single-cell perturbation modeling is fundamental for understanding and predicting cellular responses to genetic perturbations. However, existing approaches, from causal representation learning to foundation models, often struggle with an…

Graphs are a central representation in biomedical research, capturing molecular interaction networks, gene regulatory circuits, cell--cell communication maps, and knowledge graphs. Despite their importance, currently there is not a broadly…

Diffusion models deliver high-fidelity generation but remain slow at inference time due to many sequential network evaluations. We find that standard timestep conditioning becomes a key bottleneck for few-step sampling. Motivated by…

Navigation is a fundamental capability for mobile robots. While the current trend is to use learning-based approaches to replace traditional geometry-based methods, existing end-to-end learning-based policies often struggle with 3D spatial…

The prosodic aspects of speech signals produced by current text-to-speech systems are typically averaged over training material, and as such lack the variety and liveliness found in natural speech. To avoid monotony and averaged prosody…

Generative models have shown immense potential for wireless communication by learning complex channel data distributions. However, the iterative denoising process associated with these models imposes a significant challenge in…

To advance understanding of cellular metabolism and reduce batch-to-batch variability in cell culture processes, this study introduces a multi-scale hybrid modeling framework designed to simulate and predict the dynamic behavior of CHO cell…

The advent of one-step text-to-image (T2I) models offers unprecedented synthesis speed. However, their application to text-guided image editing remains severely hampered, as forcing existing training-free editors into a single inference…

Modeling the dynamics of cellular differentiation is fundamental to advancing the understanding and treatment of diseases associated with this process, such as cancer. With the rapid growth of single-cell datasets, this has also become a…

In single-cell research, tracing and analyzing high-throughput single-cell differentiation trajectories is crucial for understanding biological processes. Key to this is the robust modeling of hierarchical structures that govern cellular…

Efficient and precise prediction of plasticity by data-driven models relies on appropriate data preparation and a well-designed model. Here we introduce an unsupervised machine learning-based data preparation method to maximize the…

Diffusion-based image compression has demonstrated impressive perceptual performance. However, it suffers from two critical drawbacks: (1) excessive decoding latency due to multi-step sampling, and (2) poor fidelity resulting from…

Foundation models have recently achieved impressive success in computational pathology, demonstrating strong generalization across diverse histopathology tasks. However, existing models overlook the heterogeneous and non-uniform…

This paper develops a predictive switching control algorithm for stochastic gene regulatory networks described by a Partial Integro-Differential Equation (PIDE) model, which enables direct shape control of the probability density function.…

This work presents a new procedure to extract features of grey-level texture images based on the discrete Schroedinger transform. This is a non-linear transform where the image is mapped as the initial probability distribution of a wave…

While transferring a pretrained language model, common approaches conventionally attach their task-specific classifiers to the top layer and adapt all the pretrained layers. We investigate whether one could make a task-specific selection on…

Distilled one-step (T=1) or few-step (T$\leq$4) diffusion models enable real-time image generation but often exhibit reduced sample diversity compared to their multi-step counterparts. In multi-step diffusion, diversity can be introduced…