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Optimization strategies driven by machine learning, such as Bayesian optimization, are being explored across experimental sciences as an efficient alternative to traditional design of experiment. When combined with automated laboratory…

最优化与控制 · 数学 2022-10-18 Riley J. Hickman , Matteo Aldeghi , Florian Häse , Alán Aspuru-Guzik

Experimental (design) optimization is a key driver in designing and discovering new products and processes. Bayesian Optimization (BO) is an effective tool for optimizing expensive and black-box experimental design processes. While Bayesian…

机器学习 · 计算机科学 2024-02-28 Arun Kumar A , Alistair Shilton , Sunil Gupta , Santu Rana , Stewart Greenhill , Svetha Venkatesh

The Design of Experiments (DOEs) is a fundamental scientific methodology that provides researchers with systematic principles and techniques to enhance the validity, reliability, and efficiency of experimental outcomes. In this study, we…

机器学习 · 统计学 2025-07-22 Miao Huang , Hongqiao Wang , Kunyu Wu

The design of an experiment can be always be considered at least implicitly Bayesian, with prior knowledge used informally to aid decisions such as the variables to be studied and the choice of a plausible relationship between the…

统计方法学 · 统计学 2017-01-03 David C. Woods , Antony M. Overstall , Maria Adamou , Timothy W. Waite

Traditional accelerated life test plans are typically based on optimizing the C-optimality for minimizing the variance of an interested quantile of the lifetime distribution. The traditional methods rely on some specified planning values…

应用统计 · 统计学 2018-12-04 Lu Lu , I-Chen Lee , Yili Hong

Sequential Bayesian optimal experimental design (SBOED) for PDE-governed inverse problems is computationally challenging, especially for infinite-dimensional random field parameters. High-fidelity approaches require repeated forward and…

最优化与控制 · 数学 2026-01-12 Kaichen Shen , Peng Chen

We introduce BEDS (Bayesian Emergent Dissipative Structures), a formal framework for analyzing inference systems that must maintain beliefs continuously under energy constraints. Unlike classical computational models that assume perfect…

计算机视觉与模式识别 · 计算机科学 2026-01-08 Laurent Caraffa

We address the problem of Bayesian reinforcement learning using efficient model-based online planning. We propose an optimism-free Bayes-adaptive algorithm to induce deeper and sparser exploration with a theoretical bound on its performance…

机器学习 · 计算机科学 2020-06-30 Divya Grover , Debabrota Basu , Christos Dimitrakakis

Bayesian Experimental Design (BED), which aims to find the optimal experimental conditions for Bayesian inference, is usually posed as to optimize the expected information gain (EIG). The gradient information is often needed for efficient…

机器学习 · 统计学 2023-12-14 Ziqiao Ao , Jinglai Li

Engineering design is traditionally performed by hand: an expert makes design proposals based on past experience, and these proposals are then tested for compliance with certain target specifications. Testing for compliance is performed…

This paper proposes a new class of predictive models for survival analysis called Generalized Bayesian Ensemble Survival Tree (GBEST). It is well known that survival analysis poses many different challenges, in particular when applied to…

统计方法学 · 统计学 2025-03-18 Elena Ballante , Pietro Muliere , Silvia Figini

We consider optimal experimental design (OED) for nonlinear inverse problems within the Bayesian framework. Optimizing the data acquisition process for large-scale nonlinear Bayesian inverse problems is a computationally challenging task…

数值分析 · 数学 2024-05-14 Karina Koval , Ruanui Nicholson

Quality by design in pharmaceutical manufacturing hinges on computational methods and tools that are capable of accurate quantitative prediction of the design space. This paper investigates Bayesian approaches to design space…

Within the framework of complex system design, it is often necessary to solve mixed variable optimization problems, in which the objective and constraint functions can depend simultaneously on continuous and discrete variables.…

最优化与控制 · 数学 2020-03-10 Julien Pelamatti , Loic Brevault , Mathieu Balesdent , El-Ghazali Talbi , Yannick Guerin

Surgical scheduling optimization is an active area of research. However, few algorithms to optimize surgical scheduling are implemented and see sustained use. An algorithm is more likely to be implemented, if it allows for surgeon autonomy,…

人工智能 · 计算机科学 2022-03-17 Jin Xie , Teng Zhang , Jose Blanchet , Peter Glynn , Matthew Randolph , David Scheinker

We develop a new computational approach for "focused" optimal Bayesian experimental design with nonlinear models, with the goal of maximizing expected information gain in targeted subsets of model parameters. Our approach considers…

统计计算 · 统计学 2019-03-28 Chi Feng , Youssef M. Marzouk

Sequential Bayesian experimental design typically assumes that the number of experiments is fixed before data collection begins. In practical campaigns, however, experimentation may need to terminate early because additional measurements…

统计方法学 · 统计学 2026-05-29 Chen Cheng , Xun Huan

The construction of decision-theoretic Bayesian designs for realistically-complex nonlinear models is computationally challenging, as it requires the optimization of analytically intractable expected utility functions over high-dimensional…

统计方法学 · 统计学 2016-07-01 Antony Overstall , David Woods

For applications in healthcare, physics, energy, robotics, and many other fields, designing maximally informative experiments is valuable, particularly when experiments are expensive, time-consuming, or pose safety hazards. While existing…

机器学习 · 计算机科学 2022-03-09 Vincent Lim , Ellen Novoseller , Jeffrey Ichnowski , Huang Huang , Ken Goldberg

Bayesian optimization offers a flexible framework to optimize an objective function that is expensive to be evaluated. A Bayesian optimizer iteratively queries the function values on its carefully selected points. Subsequently, it makes a…

机器学习 · 计算机科学 2019-06-25 Yang Li , Yaqiang Yao