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Predicting the outcomes of prospective clinical trials remains a major challenge for large language models. Prior work has shown that both traditional correlational predictors, such as random forests and logistic regression, and strong…

Across medical specialties, clinical practice is anchored in evidence-based guidelines that codify best studied diagnostic and treatment pathways. These pathways routinely fall short for the long tail of real-world care not covered by…

Large language models (LLMs) have recently emerged as powerful tools, finding many medical applications. LLMs' ability to coalesce vast amounts of information from many sources to generate a response-a process similar to that of a human…

Clinical note generation aims to produce free-text summaries of a patient's condition and diagnostic process, with discharge instructions being a representative long-form example. While recent LLM-based methods pre-trained on general…

计算与语言 · 计算机科学 2025-08-12 Lo Pang-Yun Ting , Chengshuai Zhao , Yu-Hua Zeng , Yuan Jee Lim , Kun-Ta Chuang , Huan Liu

Large language models (LLMs) are widely explored for reasoning-intensive research tasks, yet resources for testing whether they can infer scientific conclusions from structured biomedical evidence remain limited. We introduce…

计算与语言 · 计算机科学 2026-04-09 Weiyue Li , Ruizhi Qian , Yi Li , Yongce Li , Yunfan Long , Jiahui Cai , Yan Luo , Mengyu Wang

The meaningful use of electronic health records (EHR) continues to progress in the digital era with clinical decision support systems augmented by artificial intelligence. A priority in improving provider experience is to overcome…

计算与语言 · 计算机科学 2023-01-30 Yanjun Gao , Dmitriy Dligach , Timothy Miller , John Caskey , Brihat Sharma , Matthew M Churpek , Majid Afshar

Answering complex medical questions requires not only domain expertise and patient-specific information, but also structured and multi-perspective reasoning. Existing multi-agent approaches often rely on fixed roles or shallow interaction…

人工智能 · 计算机科学 2026-03-04 Siqi Ma , Jiajie Huang , Fan Zhang , Yue Shen , Jinlin Wu , Guohui Fan , Zhu Zhang , Zelin Zang

Large Language Models (LLMs) are increasingly used for clinical decision support, where hallucinations and unsafe suggestions may pose direct risks to patient safety. These risks are hard to assess: subtle clinical errors are often missed…

计算与语言 · 计算机科学 2026-05-14 Yinzhu Chen , Abdine Maiga , Hossein A. Rahmani , Emine Yilmaz

An accurate differential diagnosis (DDx) is a cornerstone of medical care, often reached through an iterative process of interpretation that combines clinical history, physical examination, investigations and procedures. Interactive…

While large language models (LLMs) have demonstrated impressive capabilities across various natural language processing tasks by acquiring rich factual knowledge from their broad training data, their ability to synthesize and logically…

计算与语言 · 计算机科学 2024-07-31 Tianshi Zheng , Jiaxin Bai , Yicheng Wang , Tianqing Fang , Yue Guo , Yauwai Yim , Yangqiu Song

Recent advances in Large Language Models (LLMs) have led to remarkable progresses in medical consultation. However, existing medical LLMs overlook the essential role of Electronic Health Records (EHR) and focus primarily on diagnosis…

人工智能 · 计算机科学 2025-06-26 Weijieying Ren , Tianxiang Zhao , Lei Wang , Tianchun Wang , Vasant Honavar

Retrieval-augmented generation (RAG) has been widely adopted to ground large language models (LLMs) in external knowledge, yet it remains largely underexplored for improving reasoning. Existing methods either rely on online exploration…

人工智能 · 计算机科学 2026-02-10 Jiaxiang Chen , Zhuo Wang , Mingxi Zou , Qifan Wang , Zenglin Xu

Current approaches for strengthening LLM reasoning tend to introduce a training bias toward human-like reasoning trajectories. In step-wise preference optimization, in particular, dependence on human or higher-capacity model annotations for…

计算与语言 · 计算机科学 2026-02-03 Junjie Lu , Yuliang Liu , Chaofeng Qu , Wei Shen , Zhouhan Lin , Chuheng Zhang , Min Xu

Decision support systems based on clinical notes have the potential to improve patient care by pointing doctors towards overseen risks. Predicting a patient's outcome is an essential part of such systems, for which the use of deep neural…

计算与语言 · 计算机科学 2021-12-01 Betty van Aken , Sebastian Herrmann , Alexander Löser

Clinical document classification is essential for converting unstructured medical texts into standardised ICD-10 diagnoses, yet it faces challenges due to complex medical language, privacy constraints, and limited annotated datasets. Large…

计算与语言 · 计算机科学 2026-02-03 Akram Mustafa , Usman Naseem , Mostafa Rahimi Azghadi

Recommendation systems aim to provide users with relevant suggestions, but often lack interpretability and fail to capture higher-level semantic relationships between user behaviors and profiles. In this paper, we propose a novel approach…

Explainable disease diagnosis, which leverages patient information (e.g., signs and symptoms) and computational models to generate probable diagnoses and reasonings, offers clear clinical values. However, when clinical notes encompass…

Recent researches of large language models(LLM), which is pre-trained on massive general-purpose corpora, have achieved breakthroughs in responding human queries. However, these methods face challenges including limited data insufficiency…

计算与语言 · 计算机科学 2025-01-07 Yiming Zhang , Zheng Chang , Wentao Cai , MengXing Ren , Kang Yuan , Yining Sun , Zenghui Ding

This paper presents ReasoningRec, a reasoning-based recommendation framework that leverages Large Language Models (LLMs) to bridge the gap between recommendations and human-interpretable explanations. In contrast to conventional…

信息检索 · 计算机科学 2024-10-31 Millennium Bismay , Xiangjue Dong , James Caverlee

Large Language Models (LLMs) hold significant promise for improving clinical decision support and reducing physician burnout by synthesizing complex, longitudinal cancer Electronic Health Records (EHRs). However, their implementation in…

计算与语言 · 计算机科学 2026-01-12 Dongchen Li , Jitao Liang , Wei Li , Xiaoyu Wang , Longbing Cao , Kun Yu