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Pathology foundation models (PFMs) achieve strong performance on diverse histopathology tasks, but their sensitivity to hospital-specific domain shifts remains underexplored. We systematically evaluate state-of-the-art PFMs on TCGA…

计算机视觉与模式识别 · 计算机科学 2026-02-03 Mengliang Zhang

Pathology foundation models (PFMs) have rapidly advanced and are becoming a common backbone for downstream clinical tasks, offering strong transferability across tissues and institutions. However, for dense prediction (e.g., segmentation),…

图像与视频处理 · 电气工程与系统科学 2026-02-05 Weiming Chen , Xitong Ling , Xidong Wang , Zhenyang Cai , Yijia Guo , Mingxi Fu , Ziyi Zeng , Minxi Ouyang , Jiawen Li , Yizhi Wang , Tian Guan , Benyou Wang , Yonghong He

Foundation models (FMs) have emerged as a transformative paradigm in medical image analysis, offering the potential to provide generalizable, task-agnostic solutions across a wide range of clinical tasks and imaging modalities. Their…

计算机视觉与模式识别 · 计算机科学 2025-11-04 Karma Phuntsho , Abdullah , Kyungmi Lee , Ickjai Lee , Euijoon Ahn

Pathology Foundation Models (FMs) hold great promise for healthcare. Before they can be used in clinical practice, it is essential to ensure they are robust to variations between medical centers. We measure whether pathology FMs focus on…

机器学习 · 计算机科学 2025-02-04 Edwin D. de Jong , Eric Marcus , Jonas Teuwen

Labeling medical images is a major bottleneck in the field of medical imaging, as it requires domain-specific expertise, and it gets further complicated due to variability across different medical centers and different imaging devices. Such…

计算机视觉与模式识别 · 计算机科学 2026-05-06 Sapna Sachan , Rakesh Kumar Sanodiya , Amulya Kumar Mahto

Pathology foundation models (PFMs) have emerged as powerful pretrained encoders for computational pathology, but their robustness under clinically relevant distribution shifts remains insufficiently understood. We benchmark the robustness…

图像与视频处理 · 电气工程与系统科学 2026-04-29 Fredrik K. Gustafsson , Mattias Rantalainen

Multiple-instance learning (MIL) is an attractive approach for digital pathology applications as it reduces the costs related to data collection and labelling. However, it is not clear how sensitive MIL is to clinically realistic domain…

计算机视觉与模式识别 · 计算机科学 2024-05-17 Milda Pocevičiūtė , Gabriel Eilertsen , Stina Garvin , Claes Lundström

Diffusion probabilistic models (DPMs) have exhibited significant effectiveness in computer vision tasks, particularly in image generation. However, their notable performance heavily relies on labelled datasets, which limits their…

计算机视觉与模式识别 · 计算机科学 2024-05-09 Keqiang Fan , Xiaohao Cai , Mahesan Niranjan

Despite the significant potential of Foundation Models (FMs) in medical imaging, their application to prognosis prediction remains challenging due to data scarcity, class imbalance, and task complexity, which limit their clinical adoption.…

计算机视觉与模式识别 · 计算机科学 2026-01-16 Filippo Ruffini , Elena Mulero Ayllon , Linlin Shen , Paolo Soda , Valerio Guarrasi

Medical Foundation Models (MFMs), trained on large-scale datasets, have demonstrated superior performance across various tasks. However, these models still struggle with domain gaps in practical applications. Specifically, even after…

计算机视觉与模式识别 · 计算机科学 2025-03-04 Jia-Xuan Jiang , Wenhui Lei , Yifeng Wu , Hongtao Wu , Furong Li , Yining Xie , Xiaofan Zhang , Zhong Wang

Computational pathology foundation models (CPathFMs) have emerged as a powerful approach for analyzing histopathological data, leveraging self-supervised learning to extract robust feature representations from unlabeled whole-slide images.…

计算机视觉与模式识别 · 计算机科学 2025-02-27 Dong Li , Guihong Wan , Xintao Wu , Xinyu Wu , Ajit J. Nirmal , Christine G. Lian , Peter K. Sorger , Yevgeniy R. Semenov , Chen Zhao

With advances in digital technology, the classification of medical images has become a crucial step for image-based clinical decision support systems. Automatic medical image classification represents a pivotal domain where the use of AI…

计算机视觉与模式识别 · 计算机科学 2024-09-09 Abu Adnan Sadi , Labib Chowdhury , Nusrat Jahan , Mohammad Newaz Sharif Rafi , Radeya Chowdhury , Faisal Ahamed Khan , Nabeel Mohammed

Recent advancements in Large Multimodal Models (LMMs) have attracted interest in their generalization capability with only a few samples in the prompt. This progress is particularly relevant to the medical domain, where the quality and…

计算与语言 · 计算机科学 2024-05-06 Seonhee Cho , Choonghan Kim , Jiho Lee , Chetan Chilkunda , Sujin Choi , Joo Heung Yoon

Pathology foundation models (PFMs) have recently emerged as powerful pretrained encoders for computational pathology, enabling transfer learning across a wide range of downstream tasks. However, systematic comparisons of these models for…

计算机视觉与模式识别 · 计算机科学 2026-04-28 Fredrik K. Gustafsson , Constance Boissin , Johan Vallon-Christersson , David A. Clifton , Mattias Rantalainen

Computational pathology, which involves analyzing whole slide images for automated cancer diagnosis, relies on multiple instance learning, where performance depends heavily on the feature extractor and aggregator. Recent Pathology…

计算机视觉与模式识别 · 计算机科学 2025-05-22 Conghao Xiong , Hao Chen , Joseph J. Y. Sung

Deep learning has shown remarkable progress in medical image semantic segmentation, yet its success heavily depends on large-scale expert annotations and consistent data distributions. In practice, annotations are scarce, and images are…

计算机视觉与模式识别 · 计算机科学 2026-01-26 Ba-Thinh Lam , Thanh-Huy Nguyen , Hoang-Thien Nguyen , Quang-Khai Bui-Tran , Nguyen Lan Vi Vu , Phat K. Huynh , Ulas Bagci , Min Xu

Existing domain adaptation methods aim to reduce the distributional difference between the source and target domains and respect their specific discriminative information, by establishing the Maximum Mean Discrepancy (MMD) and the…

机器学习 · 计算机科学 2020-07-03 Wei Wang , Haojie Li , Zhengming Ding , Zhihui Wang

Domain shift, the mismatch between training and testing data characteristics, causes significant degradation in the predictive performance in multi-source imaging scenarios. In medical imaging, the heterogeneity of population, scanners and…

机器学习 · 计算机科学 2021-12-21 Rongguang Wang , Pratik Chaudhari , Christos Davatzikos

The fusion of complementary multimodal information is crucial in computational pathology for accurate diagnostics. However, existing multimodal learning approaches necessitate access to users' raw data, posing substantial privacy risks.…

计算机视觉与模式识别 · 计算机科学 2024-02-27 Yuanzhe Peng , Jieming Bian , Jie Xu

Domain adaptation has received a lot of attention in recent years, and many algorithms have been proposed with impressive progress. However, it is still not fully explored concerning the joint probability distribution (P(X, Y)) distance for…

机器学习 · 计算机科学 2021-01-26 Wei Wang , Baopu Li , Shuhui Yang , Jing Sun , Zhengming Ding , Junyang Chen , Xiao Dong , Zhihui Wang , Haojie Li
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