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Early initiation of alcohol, nicotine, cannabis, and other substances predicts later substance use disorders and related psychopathology. We integrate time-varying environmental factors with polygenic risk scores (PRS) in a longitudinal…

定量方法 · 定量生物学 2026-04-10 Mengman Wei , Qian Peng

We propose a probabilistic framework for developing computational models of biological neural systems. In this framework, physiological recordings are viewed as discrete-time partial observations of an underlying continuous-time stochastic…

神经元与认知 · 定量生物学 2026-02-10 Ahmed ElGazzar , Marcel van Gerven

Phenomics is concerned with detailed description of all aspects of organisms, from their physical foundations at genetic, molecular and cellular level, to behavioural and psychological traits. Neuropsychiatric phenomics, endorsed by NIMH,…

神经元与认知 · 定量生物学 2021-01-13 Włodzisław Duch

Large-scale neuroscience is generating rich datasets across animals, brain areas and behavioral contexts, yet our modeling efforts remains fragmented across isolated experiments. We argue that understanding behavior requires integrative…

Mental health is not a fixed trait but a dynamic process shaped by the interplay between individual dispositions and situational contexts. Building on interactionist and constructionist psychological theories, we develop interpretable…

计算与语言 · 计算机科学 2026-03-09 Nikita Soni , August Håkan Nilsson , Syeda Mahwish , Vasudha Varadarajan , H. Andrew Schwartz , Ryan L. Boyd

This review highlights brain health as a dynamic process shaped by both genetic and environmental influences throughout development. Critical periods provide unique windows of heightened neural plasticity, during which genetic-environmental…

The principled design and discovery of biologically- and physically-informed models of neuronal dynamics has been advancing since the mid-twentieth century. Recent developments in artificial intelligence (AI) have accelerated this progress.…

The correlation between children's personal and family characteristics (e.g., demographics and socioeconomic status) and their physical and mental health status has been extensively studied across various research domains, such as public…

人机交互 · 计算机科学 2024-04-11 Zhihan Jiang , Handi Chen , Rui Zhou , Jing Deng , Xinchen Zhang , Running Zhao , Cong Xie , Yifang Wang , Edith C. H. Ngai

We propose HyperDynamics, a dynamics meta-learning framework that conditions on an agent's interactions with the environment and optionally its visual observations, and generates the parameters of neural dynamics models based on inferred…

机器人学 · 计算机科学 2021-03-18 Zhou Xian , Shamit Lal , Hsiao-Yu Tung , Emmanouil Antonios Platanios , Katerina Fragkiadaki

This review provides a dynamical systems perspective on psychiatric symptoms and disease, and discusses its potential implications for diagnosis, prognosis, and treatment. After a brief introduction into the theory of dynamical systems, we…

神经元与认知 · 定量生物学 2018-09-18 Daniel Durstewitz , Quentin J. M. Huys , Georgia Koppe

Humans and animals exhibit a range of interesting behaviors in dynamic environments, and it is unclear how our brains actively reformat this dense sensory information to enable these behaviors. Experimental neuroscience is undergoing a…

神经元与认知 · 定量生物学 2023-11-07 Aran Nayebi

The measurement of human behavior remains a central challenge across the behavioral sciences. Traditional approaches typically rely on passive observation of responses collected under static or weakly controlled conditions, limiting the…

统计方法学 · 统计学 2026-03-31 Pietro Cipresso

Many, if not most, systems of interest in science are naturally described as nonlinear dynamical systems. Empirically, we commonly access these systems through time series measurements. Often such time series may consist of discrete random…

机器学习 · 计算机科学 2024-06-10 Manuel Brenner , Florian Hess , Georgia Koppe , Daniel Durstewitz

Assessment of job performance, personalized health and psychometric measures are domains where data-driven and ubiquitous computing exhibits the potential of a profound impact in the future. Existing techniques use data extracted from…

Reliable stress recognition is critical in applications such as medical monitoring and safety-critical systems, including real-world driving. While stress is commonly detected using physiological signals such as perinasal perspiration and…

计算机视觉与模式识别 · 计算机科学 2026-05-05 Paraskevi Valergaki , Vassilis C. Nicodemou , Iason Oikonomidis , Antonis Argyros , Anastasios Roussos

Understanding how decision making changes across the lifespan is a central challenge for neuroscience, yet research on cognitive aging has remained largely disconnected from the theoretical and computational advances that now shape modern…

神经元与认知 · 定量生物学 2026-03-04 Michael B. Ryan , Letizia Ye , Anne K. Churchland

This paper introduces a biomathematical model designed to describe the internal dynamics of dream formation and spontaneous cognitive processes. The model incorporates neurocognitive factors such as dissatisfaction, acceptance, forgetting,…

神经元与认知 · 定量生物学 2025-05-12 Shirmohammad Tavangari , Sajjad Janfaza , Zahra Shakarami , Aref Yelghi

Predicting dynamic behaviors is one of the goals of science in general as well as essential to many specific applications of human knowledge to real world systems. Here we introduce an analytic approach using the sigmoid growth curve to…

Multi-agent systems often operate under feedback, adaptation, and non-stationarity, yet many simulation studies retain static decision rules and fixed control parameters. This paper introduces a general adaptive multi-agent learning…

多智能体系统 · 计算机科学 2025-11-26 Roberto Garrone

The brain-body-environment framework studies adaptive behavior through embodied and situated agents, emphasizing interactions between brains, biomechanics, and environmental dynamics. However, many models often treat the brain as a network…

神经元与认知 · 定量生物学 2025-10-01 Denizhan Pak , Quan Le Thien , Christopher J. Agostino
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