相关论文: Toward Personalized Digital Twins for Cognitive De…
Simulating glucose dynamics in individuals with type 1 diabetes (T1D) is critical for developing personalized treatments and supporting data-driven clinical decisions. Existing models often miss key physiological aspects and are difficult…
This paper presents a novel deep learning-based approach named RealDiffFusionNet incorporating Neural Controlled Differential Equations (Neural CDE) - time series models that are robust in handling irregularly sampled data - and multi-head…
Parkinsons Disease (PD) is a progressive neurological disorder that primarily affects motor functions and can lead to mild cognitive impairment (MCI) and dementia in its advanced stages. With approximately 10 million people diagnosed…
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that severely impairs cognitive function and quality of life. Timely intervention in AD relies heavily on early and precise diagnosis, which remains challenging due to the…
Serious games have proven to be effective tools for screening cognitive impairments and supporting diagnosis in patients with neurodegenerative diseases like Alzheimer's and Parkinson's. They also offer cognitive training benefits.…
Neuro-oncological prognostics are now vital in modern clinical neuroscience because brain tumors pose significant challenges in detection and management. To tackle this issue, we propose a cognitive digital twin framework that combines…
Human digital twins (HDTs) are dynamic, data-driven virtual representations of individuals, continuously updated with multimodal data to simulate, monitor, and predict health trajectories. By integrating clinical, physiological, behavioral,…
Failure to timely diagnose and effectively treat depression leads to over 280 million people suffering from this psychological disorder worldwide. The information cues of depression can be harvested from diverse heterogeneous resources,…
The development of a digital twin (DT) framework for fast online adaptive proton therapy planning in prostate stereotactic body radiation therapy (SBRT) with dominant intraprostatic lesion (DIL) boost represents a significant advancement in…
Deep learning has shown significant potential in diagnosing neurodegenerative diseases from MRI data. However, most existing methods rely heavily on large volumes of labeled data and often yield representations that lack interpretability.…
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia, affecting memory, reasoning, communication, and daily functioning. Early diagnosis is particularly important, as timely intervention may…
Recent advancements in deep learning have shifted the development of brain imaging analysis. However, several challenges remain, such as heterogeneity, individual variations, and the contradiction between the high dimensionality and small…
Diagnosing dementia, particularly for Alzheimer's Disease (AD) and frontotemporal dementia (FTD), is complex due to overlapping symptoms. While magnetic resonance imaging (MRI) and positron emission tomography (PET) data are critical for…
Depression poses serious public health risks, including suicide, underscoring the urgency of timely and scalable screening. Multimodal automatic depression detection (ADD) offers a promising solution; however, widely studied audio- and…
Here we present DIVE: Data-driven Inference of Vertexwise Evolution. DIVE is an image-based disease progression model with single-vertex resolution, designed to reconstruct long-term patterns of brain pathology from short-term longitudinal…
Parkinson's disease (PD) and Alzheimer's disease (AD) are the two most prevalent and incurable neurodegenerative diseases (NDs) worldwide, for which early diagnosis is critical to delay their progression. However, the high dimensionality of…
Early and accurate diagnosis of Alzheimer's disease (AD) and its prodromal period mild cognitive impairment (MCI) is essential for the delayed disease progression and the improved quality of patients'life. The emerging computer-aided…
Coupled tensor decompositions (CTDs) perform data fusion by linking factors from different datasets. Although many CTDs have been already proposed, current works do not address important challenges of data fusion, where: 1) the datasets are…
Background: Medical Digital Twins (MDTs) are computational representations of individual patients that integrate clinical, genomic, and physiological data to support diagnosis, treatment planning, and outcome prediction. However, most MDTs…
Major depressive disorder (MDD) is a heterogeneous condition; multiple underlying neurobiological substrates could be associated with treatment response variability. Understanding the sources of this variability and predicting outcomes has…