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Disentangled and interpretable latent representations in generative models typically come at the cost of generation quality. The $\beta$-VAE framework introduces a hyperparameter $\beta$ to balance disentanglement and reconstruction…

机器学习 · 计算机科学 2025-07-10 Anshuk Uppal , Yuhta Takida , Chieh-Hsin Lai , Yuki Mitsufuji

We consider problems where multiple predictions can be considered correct, but only one of them is given as supervision. This setting differs from both the regression and class-conditional generative modelling settings: in the former, there…

机器学习 · 计算机科学 2020-12-02 Shichong Peng , Ke Li

This paper aims to address the challenge of data generation beyond the training data and proposes a framework for Structural Extrapolated Data GEneration (SEDGE) based on suitable assumptions on the underlying data-generating process. We…

机器学习 · 计算机科学 2026-05-15 Kun Zhang , Jiaqi Sun , Yiqing Li , Ignavier Ng , Namrata Deka , Shaoan Xie

Synthesizability in small molecule generative design remains a bottleneck. Existing works that do consider synthesizability can output predicted synthesis routes for generated molecules. However, there has been minimal attention in…

生物大分子 · 定量生物学 2025-05-14 Jeff Guo , Víctor Sabanza-Gil , Zlatko Jončev , Jeremy S. Luterbacher , Philippe Schwaller

The development of a complex disease is an intricate interplay of genetic and environmental factors. "Heritability" is defined as the proportion of total trait variance due to genetic factors within a given population. Studies with…

统计方法学 · 统计学 2018-10-19 Jaron Arbet , Matt McGue , Saonli Basu

Language models (LMs) perform well on standardized coding benchmarks but struggle with real-world software engineering tasks such as resolving GitHub issues in SWE-Bench, especially when model parameters are less than 100B. While smaller…

With the growing complexity of deep learning methods adopted in practical applications, there is an increasing and stringent need to explain and interpret the decisions of such methods. In this work, we focus on explainable AI and propose a…

机器学习 · 计算机科学 2020-08-05 Antonio Barbalau , Adrian Cosma , Radu Tudor Ionescu , Marius Popescu

A central goal in systems biology and drug discovery is to predict the transcriptional response of cells to perturbations. This task is challenging due to the noisy and sparse nature of single-cell measurements, as well as the fact that…

定量方法 · 定量生物学 2026-02-10 Chenglei Yu , Chuanrui Wang , Bangyan Liao , Tailin Wu

Deep generative models applied to audio have improved by a large margin the state-of-the-art in many speech and music related tasks. However, as raw waveform modelling remains an inherently difficult task, audio generative models are either…

机器学习 · 计算机科学 2021-12-16 Antoine Caillon , Philippe Esling

Conditional generation models for longitudinal sequences can produce new or modified trajectories given a conditioning input. However, they often lack control over when the condition should take effect (timing) and which variables it should…

机器学习 · 计算机科学 2026-03-10 Michelle M. Li , Kevin Li , Yasha Ektefaie , Ying Jin , Yepeng Huang , Shvat Messica , Tianxi Cai , Marinka Zitnik

In single-cell research, tracing and analyzing high-throughput single-cell differentiation trajectories is crucial for understanding biological processes. Key to this is the robust modeling of hierarchical structures that govern cellular…

机器学习 · 计算机科学 2026-05-19 Zelin Zang , WenZhe Li , Yongjie Xu , Chang Yu , Changxi Chi , Jingbo Zhou , Zhen Lei , Stan Z. Li

In this paper, we incorporate physical knowledge into learning-based high-precision target sensing using the multi-view channel state information (CSI) between multiple base stations (BSs) and user equipment (UEs). Such kind of multi-view…

信号处理 · 电气工程与系统科学 2026-02-27 Ziqing Xing , Zhaoyang Zhang , Zirui Chen , Hongning Ruan , Zhaohui Yang , Zhiyong Feng

Coordination behavior in robot swarms is inherently multi-modal in nature. That is, there are numerous ways in which a swarm of robots can avoid inter-agent collisions and reach their respective goals. However, the problem of generating…

机器人学 · 计算机科学 2025-02-03 Simon Idoko , B. Bhanu Teja , K. Madhava Krishna , Arun Kumar Singh

Causation discovery without manipulation is considered a crucial problem to a variety of applications. The state-of-the-art solutions are applicable only when large numbers of samples are available or the problem domain is sufficiently…

人工智能 · 计算机科学 2017-07-06 Ruichu Cai , Zhenjie Zhang , Zhifeng Hao

Learning latent expression themes that best express complex patterns in a sample is a central problem in data mining and scientific research. For example, in computational biology we seek a set of salient gene expression themes that explain…

定量方法 · 定量生物学 2007-11-19 Edoardo M Airoldi , Stephen E Fienberg , Eric P Xing

Many real-world optimization problems are not naturally homogeneous vectors but composite design objects with heterogeneous parameters: integers, real values, Booleans, categoricals, complex-valued descriptors, and embedding vectors.…

神经与进化计算 · 计算机科学 2026-05-14 Alex Bogdan

Synthetic data generation has emerged as a crucial topic for financial institutions, driven by multiple factors, such as privacy protection and data augmentation. Many algorithms have been proposed for synthetic data generation but reaching…

机器学习 · 计算机科学 2024-05-13 Shinpei Nakamura-Sakai , Fadi Hamad , Saheed Obitayo , Vamsi K. Potluru

A significant challenge facing current optical flow and stereo methods is the difficulty in generalizing them well to the real world. This is mainly due to the high costs required to produce datasets, and the limitations of existing…

计算机视觉与模式识别 · 计算机科学 2024-10-15 Han Ling , Yinghui Sun , Quansen Sun , Ivor Tsang , Yuhui Zheng

Quantum denoising diffusion models have recently emerged as a powerful framework for generative quantum machine learning. In this work, we extend these models by introducing a conditioning mechanism that enables the generation of quantum…

量子物理 · 物理学 2025-09-23 Daniel Quinn , Lorenzo Buffoni , Stefano Gherardini , Gabriele De Chiara

Neural sequence to sequence models are well established for applications which can be cast as mapping a single input sequence into a single output sequence. In this work, we focus on cases where generation is conditioned on both a short…

计算与语言 · 计算机科学 2019-11-25 Xinyi Wang , Jason Weston , Michael Auli , Yacine Jernite