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It is well known that changing the intervention package while a trial is ongoing does not lead to valid inference using standard statistical methods. However, it is often necessary to adapt, tailor, or tweak a complex intervention package…

统计方法学 · 统计学 2023-07-14 Ante Bing , Donna Spiegelman , Daniel Nevo , Judith J. Lok

In learn-as-you-go (LAGO) adaptive studies, the intervention is a complex package consisting of multiple components, and is adapted in stages during the study based on past outcome data. This design formalizes standard practice, and desires…

统计方法学 · 统计学 2019-01-24 Daniel Nevo , Judith J. Lok , Donna Spiegelman

In the face of vast numbers of preventable deaths worldwide and gaping disparities in their distribution, we cannot afford to conduct null and inconclusive effectiveness and implementation trials of evidence-based interventions. The gold…

The Learn-As-you-GO (LAGO) design provides a rigorous framework for adapting the intervention package based on accumulating data while the trial is ongoing. This article improves the flexibility of the LAGO design by incorporating…

统计方法学 · 统计学 2025-09-16 Ante Bing , Donna Spiegelman , Judith J. Lok

Despite its promise, imitation learning often fails in long-horizon environments where perfect replication of demonstrations is unrealistic and small errors can accumulate catastrophically. We introduce Cago (Capability-Aware Goal…

人工智能 · 计算机科学 2026-01-14 Yuanlin Duan , Yuning Wang , Wenjie Qiu , He Zhu

Latent confounders---unobserved variables that influence both treatment and outcome---can bias estimates of causal effects. In some cases, these confounders are shared across observations, e.g. all students taking a course are influenced by…

统计方法学 · 统计学 2020-07-15 Sam Witty , Kenta Takatsu , David Jensen , Vikash Mansinghka

Causal variable selection in time-varying treatment settings is challenging due to evolving confounding effects. Existing methods mainly focus on time-fixed exposures and are not directly applicable to time-varying scenarios. We propose a…

We introduce Learning-Augmented Control (LAC), an approach that integrates untrusted machine learning predictions into the control of constrained, nonlinear dynamical systems. LAC is designed to achieve the "best-of-both-worlds" guarantees,…

系统与控制 · 电气工程与系统科学 2025-07-22 Tongxin Li

Measuring treatment effects in observational studies is challenging because of confounding bias. Confounding occurs when a variable affects both the treatment and the outcome. Traditional methods such as propensity score matching estimate…

统计方法学 · 统计学 2021-12-23 Bevan I. Smith , Charles Chimedza

We consider the problem of estimating and inferring treatment effects in randomized experiments. In practice, stratified randomization, or more generally, covariate-adaptive randomization, is routinely used in the design stage to balance…

统计方法学 · 统计学 2022-09-27 Hanzhong Liu , Fuyi Tu , Wei Ma

Confounding can lead to spurious associations. Typically, one must observe confounders in order to adjust for them, but in high-dimensional settings, recent research has shown that it becomes possible to adjust even for unobserved…

统计方法学 · 统计学 2025-10-07 Yujing Lu , Patrick Breheny

Numerous algorithms have been developed for Conditional Average Treatment Effect (CATE) estimation. In this paper, we first highlight a common issue where many algorithms exhibit inconsistent learning behavior for the same instance across…

机器学习 · 计算机科学 2025-07-08 Yi-Fu Fu , Keng-Te Liao , Shou-De Lin

We study the identification and estimation of long-term treatment effects when both experimental and observational data are available. Since the long-term outcome is observed only after a long delay, it is not measured in the experimental…

统计方法学 · 统计学 2024-09-04 Guido Imbens , Nathan Kallus , Xiaojie Mao , Yuhao Wang

Longitudinal analysis is important in many disciplines, such as the study of behavioral transitions in social science. Only very recently, feature selection has drawn adequate attention in the context of longitudinal modeling. Standard…

统计方法学 · 统计学 2016-10-26 Tingyang Xu , Jiangwen Sun , Jinbo Bi

Large language models (LLMs) show potential as simulators of human behavior, offering a scalable way to study responses to interventions. However, because LLMs are trained largely on observational data, interventions in experiments with…

计算与语言 · 计算机科学 2026-05-21 Victoria Lin , Taedong Yun , Maja Matarić , John Canny , Arthur Gretton , Alexander D'Amour

Several instance-based explainability methods for finding influential training examples for test-time decisions have been proposed recently, including Influence Functions, TraceIn, Representer Point Selection, Grad-Dot, and Grad-Cos.…

机器学习 · 计算机科学 2021-11-09 Karthikeyan K , Anders Søgaard

Researchers are often interested in learning not only the effect of treatments on outcomes, but also the pathways through which these effects operate. A mediator is a variable that is affected by treatment and subsequently affects outcome.…

统计方法学 · 统计学 2021-12-22 Jeremiah Jones , Ashkan Ertefaie , Robert L. Strawderman

In many social, behavioral, and biomedical sciences, treatment effect estimation is a crucial step in understanding the impact of an intervention, policy, or treatment. In recent years, an increasing emphasis has been placed on…

统计方法学 · 统计学 2024-10-10 Xinhai Zhang , Xingye Qiao

Large reasoning models have achieved remarkable performance through extended chain-of-thought sequences, yet this computational freedom leads to excessive token generation even for simple problems. We present Length-Adaptive Policy…

人工智能 · 计算机科学 2025-08-15 Xingyu Wu , Yuchen Yan , Shangke Lyu , Linjuan Wu , Yiwen Qiu , Yongliang Shen , Weiming Lu , Jian Shao , Jun Xiao , Yueting Zhuang

The fundamental problem in treatment effect estimation from observational data is confounder identification and balancing. Most of the previous methods realized confounder balancing by treating all observed pre-treatment variables as…

统计方法学 · 统计学 2021-10-13 Anpeng Wu , Kun Kuang , Junkun Yuan , Bo Li , Runze Wu , Qiang Zhu , Yueting Zhuang , Fei Wu
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